I am hearing more and more the word REVERSION (and I have written a couple of articles about preclinical phase), so here is another pearl.
onclive.com/view/bioenginee...
In the study, researchers used a bioengineered bone marrow model to understand how osteosarcoma cells interact with their environment—especially in the bone marrow, where they often go to hide and resist treatment.
One of the most exciting insights is the idea that metastasis might not be permanent. By changing specific conditions in the tumor microenvironment—like oxygen levels or the behavior of immune cells such as macrophages—it may be possible to revert cancer cells from a metastatic (aggressive) to a nonmetastatic (less dangerous) state.
This concept, called phenotypic reversion, could mean that metastatic tumors might be made less aggressive and more treatable, for instance by surgery. Drugs already exist that can manipulate oxygen tension or immune cell behavior, making this a promising direction for future therapies.
In short, the model not only helps scientists study how metastasis happens, but also opens the door to controlling or reversing it—a potentially game-changing approach in cancer treatment.
Doxycycline
