Joint pain: I do 1, 2, 3, 4. And NPP. I... - Fight Prostate Ca...

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Joint pain

PCaWarrior profile image
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I do 1, 2, 3, 4. And NPP. I also do 9 but not for joint pain. I prodded this AI to include NPP and it gave the stupid party line about liver toxicity, cholesterol elevation, etc. All 100% wrong! But good politics.

Joint pain (back rehab, knees, etc)

This is a little outside the scope of this book. But we are older, and joint pain is common during ADT.

Below is a list of strategies for managing sore joints with each option rated on a scale from A (most effective) to F (least effective) based on current evidence, overall benefits, and long-term outcomes.

1. Physical Therapy & Exercise (A)

Targeted exercises that strengthen the muscles around the knee—especially the quadriceps, hamstrings, and glutes—improve joint stability and reduce pain. Low-impact activities like swimming and cycling are particularly beneficial and have robust supporting evidence.

2. Weight Management (A)

Reducing body weight decreases the load on the knees, significantly alleviating pain and slowing joint degeneration. Studies consistently show that even modest weight loss improves knee function and symptoms.

3. Red Light Therapy (B–)

Red light therapy (low-level laser therapy) may help reduce inflammation and promote tissue repair by increasing circulation. While some studies show promising short-term relief, long-term benefits and optimal protocols remain somewhat variable.

4. Electrical Muscle Stimulation (EMS) (B)

EMS uses electrical impulses to induce muscle contractions, which can help strengthen the muscles around the knee and support joint stability. Evidence suggests that EMS can be a useful adjunct to traditional exercise, especially in patients with limited mobility, although it is generally less effective as a standalone treatment for long-term pain relief.

5. RICE Protocol (B)

Rest, ice, compression, and elevation are effective for acute injuries or flare-ups, reducing inflammation and pain temporarily. This approach is more palliative and does not address long-term underlying causes.

6. Over-the-Counter NSAIDs (B–)

Medications such as ibuprofen or naproxen can effectively reduce pain and inflammation in the short term. However, long-term use may lead to side effects such as gastrointestinal issues, and these drugs do not resolve underlying structural problems.

7. Supportive Devices (C+)

Knee braces, orthotics, or supportive footwear can provide temporary stabilization and pain relief. Their effectiveness varies among individuals, and they are best used as part of a broader treatment plan.

8. Topical Treatments (C)

Creams or gels containing NSAIDs, menthol, or capsaicin offer localized relief. These can be useful for mild to moderate pain but generally provide less potent results compared to systemic therapies.

9. Natural Supplements (D)

Supplements such as curcumin (from turmeric) or omega-3 fatty acids have anti-inflammatory properties, but evidence is mixed and product quality can vary widely, limiting their effectiveness as a sole treatment.

________________________________________

10. References

1. URL: mayoclinic.org/diseases-con... – Title: “Knee Pain: Diagnosis and Treatment – Mayo Clinic”

2. URL: healthline.com/health/knee-... – Title: “Knee Pain: Causes, Treatment, and Prevention – Healthline”

3. URL: nhs.uk/conditions/knee-pain/ – Title: “Knee Pain – NHS”

4. URL: medicalnewstoday.com/articl... – Title: “Red Light Therapy: Uses, Benefits, and More – Medical News Today”

5. URL: ncbi.nlm.nih.gov/pmc/articl... – Title: “Electrical Muscle Stimulation: A Systematic Review of the Literature”

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Bhraen2 profile image
Bhraen2

Have you tried peptides like BPC 157 or TB 500.

PCaWarrior profile image
PCaWarrior in reply toBhraen2

No I haven't. Your thoughts?

Bhraen2 profile image
Bhraen2 in reply toPCaWarrior

They both seem to be effective especially when used in combination. BPC 157 seems to be safe for cancer patients. TB 500 has some warnings for cancer patients. I have used oral BPC 157 and it seemed to help. I plan on using sub q injections next time I use it. Supposed to be much more effective for joints and muscle soreness

Bhraen2 profile image
Bhraen2

There are a lot of peptides that have anti cancer properties. Take a look at Mots C, Thymosin Alpha 1, GHK Cu, Epitalon. They are popular because they are more well known for their anti aging properties but also have shown anti cancer properties.

PCaWarrior profile image
PCaWarrior in reply toBhraen2

I've used Thymosin alpha 1. I had low WBC and RBC. After first use my WBCs went up. Then they went back down and using more didn't seem to do anything. Maybe I'll check again. See if perhaps I can only use it periodically.

Also, since starting BAT my WBCs went up a lot and my RBCs are just above the upper limit of normal.

Peptide Primary Mechanism/Effects Approx. Cost PCa Treatment Potential Muscle Health Potential Inflammation/Other Health Effects Quality of Evidence Quality of Theory

PNC-27 Derived from a p53 region; selectively binds to cancer cell membranes to induce cell death (apoptosis/necrosis) Research-grade; high/variable Experimental; promising preclinical anti cancer activity Not indicated Not established Low (primarily in vitro/preclinical) Experimental; early stage

Thymalin Thymic peptide that modulates immune function and may stimulate T cell maturation ~$50–$100 per course Indirect support via immune modulation (no direct anti PCa data) Limited direct effect May reduce systemic inflammation; immune support Low to Moderate (clinical use in Eastern Europe) Moderately established in immunomodulation

Thymogen Short thymic peptide; modulates immune responses and may help restore immunocompetence ~$30–$70 per course Indirect support as adjunct via immune modulation Not indicated Anti inflammatory potential; immune support Low to Moderate (used in Russia) Well established in immune theory

MOTS c Mitochondrial derived peptide that regulates metabolic homeostasis, enhances insulin sensitivity, and may influence muscle metabolism ~$100–$200 per vial (research grade) Limited evidence; theoretical indirect benefit through metabolic control May improve muscle metabolism; emerging data Some potential anti inflammatory effects Low (mostly animal/preclinical studies) Emerging; promising but preliminary

Thymosin Alpha 1 Enhances T cell function; used as an immunomodulator in viral infections and as adjunct in cancer therapy ~$200–$400 per course Some clinical data as an adjunct in cancer therapy (including PCa) No direct effect on muscle mass Reduces inflammatory responses; immune enhancement Moderate (several clinical studies exist) Well established in immunotherapy

GHK Cu A copper binding peptide that promotes wound healing, collagen synthesis, and tissue regeneration ~$50–$150 per vial Limited direct evidence; mainly used for skin/tissue repair May support repair processes; indirect benefit Demonstrates anti inflammatory and regenerative properties Low to Moderate (cosmetic/regenerative focus) Moderately established in tissue repair

Epitalon Claimed to activate telomerase, with proposed anti aging effects and possible modulation of cellular senescence ~$100–$300 per course Limited and mainly in vitro/animal data; controversial anti cancer hints Not directly related May reduce markers of aging and inflammation Low (predominantly preclinical studies) Controversial; emerging anti aging theory

BPC 157 Promotes angiogenesis and tissue repair; exhibits anti inflammatory effects; supports gastrointestinal, tendon, and muscle healing ~$20–$100 per vial Not directly indicated for PCa; mainly used for tissue repair Strong potential for muscle and tendon repair Robust anti inflammatory and healing properties Low to Moderate (mainly animal studies, anecdotal reports) Promising but not fully established

TB 500 (Thymosin Beta 4) Facilitates cell migration and tissue repair; promotes wound healing and modulates inflammation ~$50–$150 per vial Not directly targeted for PCa; caution warranted in oncologic contexts Well known for supporting muscle repair and regeneration Anti inflammatory; supports overall tissue healing Low to Moderate (preclinical/anecdotal clinical use) Moderately established for healing

Others (various) A range of experimental peptides (e.g., growth hormone secretagogues, other thymic or mitochondrial peptides) with mechanisms that vary by compound Highly variable (typically moderate) Some may have anticancer or supportive roles; highly compound specific Some target muscle growth or repair; depends on specific agent Effects vary widely (from anti inflammatory to regenerative) Varies from low to moderate Varies; many remain experimental

Bhraen2 profile image
Bhraen2

PNC 27 , Thymalin , Thymagen . Anti cancer properties are the main effects of these

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