I’m not sure how you see it, but for me, the ethical concern doesn’t apply in this case. She’s a virologist, guided by a team of oncologists, so I don’t see how a reasonable person would consider doing something similar without the same scientific background and context!
But check her our here:
I've been watching this group but nothing specific to prostate yet:tiltbio.com/pipeline/
Yes, solid tumors usually include prostate so I think TILT-123 could be tested on PCa as well. Also Imugene was working on something for solid tumors, but now they seem focused on cholangiocarcinoma (they had a complete remission for over 24 months in phase 1)
And now that I think about it, cancer seems to hate bacteria 
so there are companies that are developing platforms for genetically modified bacteria to treat cancer and create an immune response.
I wish they would hurry things along!
Yes, rate of discovery increased exponentially, clinical trials are safer and safer, but still they require a long time. At the end of the day China will take over as I think they take 5 years only to get from discovery to commercialized drug.
Agreed but I find it difficult to monitor their results.
chictr.org.cn/searchprojEN.... we must also consider that many major US and EU pharma companies are opening their own plants and research centers in China
"Phase II clinical trial of lopinavir/ritonavir in patients with castration-resistant prostate cancer" , chinese pragamatism, focus on repurposing and on fields that are not yet exploited so we can have a fight...in fact they seem to be very good at DNA/RNA manipulation and as you can see from the title above, they move fast also with repurposing. I wonder if I could find the results of phase 1 of that trial!
ok, got it:
The study also explored cabazitaxel, which is supposed to have a lower affinity for P-gp [44]. Although preclinical studies suggested cabazitaxel’s potency in P-gp-associated resistant cell lines, the study confirmed that cabazitaxel is indeed a P-gp substrate. Increased P-gp expression was identified as a driver of cabazitaxel resistance, and knocking down ABCB1 restored sensitivity. Combining cabazitaxel with ritonavir showed the same synergistic effects in docetaxel-resistant cell lines as seen with docetaxel. Overall, the study demonstrates that ritonavir reverses resistance to both docetaxel and cabazitaxel in prostate cancer cell lines by inhibiting P-gp-mediated drug efflux [39].
The use of ritonavir as a booster for taxane anticancer drugs has been explored in clinical trials. Several doses of new solid formulations of docetaxel ModraDoc001 (10 mg docetaxel, freeze-dried) and ModraDoc006 (10 mg docetaxel, spray-dried) with ritonavir (100 mg) were tested first in a phase I clinical trial in patients with diverse cancer types (NCT01173913). The maximum tolerated dose (MTD) was determined to be 20/20 mg twice weekly for ModraDoc001 capsules and 30/20 mg twice weekly for ModraDoc006 tablets. Treatment-related toxicity was mainly grade 1 or 2 and manageable with dose adjustments. No unexpected safety issues were noted, consistent with the known safety profile of intravenous (IV) docetaxel. The docetaxel exposure at the MTD for the ModraDoc006 tablet formulation was comparable to once-weekly IV docetaxel. The interpatient variability for ModraDoc006 was like that of IV docetaxel. Promising antitumor activity was observed. Because of this, ModraDoc006 and ritonavir were chosen for further exploration [45]. This occurred in a phase II study of this drug boosted with ritonavir in metastatic castration-resistant prostate cancer (mCRPC) patients (NCT04028388). ModraDoc006/r demonstrated a favorable safety profile and comparable efficacy to IV docetaxel in mCRPC patients, supporting the further development and expansion of clinical trials comparing ModraDoc006/r to the best available therapies for refractory mCRPC [46].
Hi Maxone, any info suggesting that docetaxel + retonvir combo overcomes the taxene resistance as outcome?
For example: dovepress.com/nanoparticlee...
Some bacteria can be worse than cancer as long as they have a bacteriophage to shut it down.
I wonder if they did genetic testing before and after on the tumor, and is that data available? Oh and what were the viruses?
“Analysis of the tumour after removal showed that it was thoroughly infiltrated with immune cells called lymphocytes,”
Wow! Great news. Wonder why it hasn't been used more often.
NOT political and please no political response but Elon Musk has been appointed as government efficiency department so maybe just maybe we can speed things up a bit.
I saw how he really jumped NASA’s space program into high gear. Just looking at the cockpit of the last space shuttle and the first space X rocket was shocking. From flipping switches and turning dials to touch screens and high tech space suits. I want the FDA modernized big time. I worked in military and we always joked we deploy yesterday’s technology tomorrow. It’s no joke !
Thanks for that. Not everyone has 10-15 years to wait until the GOLD STANDARD is reached.
Yes, we must help ourselves as we can 👍👍
Power Grid stability
Psa result
Broccoli Sprouts--loaded with sulforophane--a must for your dietary attack on PCa..How Big Pharma and the Cost of Phase III clinical trials results in needless delays and deaths !!!Immunotherapy-- Car-T, Dendritic Cell Vaccines, and BiTE... Why hasn't this been more effective??
