The University of Maryland reported two cases of terminated PCs by combining standard care treatment with an alternative treatment. By reducing the PSAs to less than 3, the clioquinol + zinc killed more cancer than testosterone could renew, therefore termination.
My PSA in three months went from 58 to 70 with alternative treatment so I intend to take two Relugolix pills to lower it and continue the alternative care.
My oncologist disagrees as does my naturopath but the U of M demonstrated what works.
What say you.
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agnut
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Two 120mg one time and check PSA two weeks later. I think two pills will lower it enough that Clio +zinc will kill more cancer than testosterone can replace. Terminating the cancer.
You might ask your MO about your program of one time use of Orgovyx every two weeks. Firmagon is a similar drug (GnRH antagonist) and requires some time to reduce testosterone which is what controls PSA. The trial use is daily dosing.
agnut - I doubt you will ever get an MO to support any truly "alternative" treatment, which this surely is. Some Naturopathic docs might do so, but it doesn't seem surprising that yours does not.
I started taking quercetin + zinc and/or using inonic zinc liquid (Trace Minerals) for COVID protection (immune boost) and cellular hit to PCa. (Another bit of hat-tip advice from our old pal, Nal.) I have recently added EGCG (Source Naturals has a pure EGCG formulation @ 350 mg per caplet) to the mix based on this research. The Maryland study using clioquinol is an intriguing one.
Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate: From Hepa 1-6 Cells to a Liposome Model
Like many contributors here, you have chosen to be an n=1 patient . Let us know how it goes with the combo. Thanks for sharing your experience. Stay Safe & Well. Ciao - cujoe
In addition to my SoC, I've engaged a functional medicine doctor who has put me on a shed load of supplements designed to block the pathways PCa use as well as mistletoe therapy. It'll be interesting to see how effective this is as it's quite expensive!
Two cases. Must be the old Leslie Costello paper, never confirmed by any other research or anything (and never peer reviewed). It tackled prolactin as well. It should at least not hurt if it won't help, so it's worth trying.
I have tried to contact him through my institutional researcher email but I never got an answer.
Zinc is one strange beast, excess of zinc is linked to the development of aggressive prostate cancer, but it seems that once you have an aggressive prostate cancer then it helps to fight it. And it seems that such properties are common to other nutrients, they turn from good to bad and vice versa according to your stage. That's why I would not rule out anything as long as I am sure it does not hurt the situation.
About clioquinol and zinc
mathewsopenaccess.com/full-... (warn you, this journal is considered a predatory publisher which means "you pay, we publish anything no question asked")
The researchers work for a university. I would at least expect other researchers to confirm their findings or to find more than one or two names as the authors of the research (always the same old names). Respectable publishers would publish everything that can be peer reviewed, as they have done many times in the past.
Sorry to edit my post so late, but just to give you an example:
annalsofoncology.org/articl...
a pity that I am metastatic and high volume...but that was a clinical trial done by a university with no external funding and published by a reputable journal which, by your parameters, should have never published this
Yes zinc is a strange beast but I’m not fully convinced they did the study right on it contributing to Pca, they’ll probably come out in 10 years or so reversing their analysis…
The problem here is that it can make you go blind or end up completely debilitated and in a wheel chair or worse . If it works for the researchers they know exactly what dosages etc. I think it is playing with fire.
Honestly, if I were one of the two guys that were cured by that protocol (or by any protocol for that matter) I would make so much noise that the researchers would end up on Time magazine’s cover in no time!!
And I would probably tell all the people I know with PCa about this research and I doubt it would stop at two patients, since I would be the living proof of its effects and there would be more volunteers. It’s a cheap medication, any university anywhere could do it, researchers share information.
I wrote the authors to know more about it and to understand how to spread the news, but never got a reply.
The issue is, it’s a cheap med that’s effective early on and you know who, would never do any clinical trials and the let the word get out. It’s a shame big pharma is not as altruistic as you and I and most of us are…
They are clinical trials....the study we are referring to from the original post is a clinical trial (small but clinical, I cannot comment on the quality as it's not my field, but still clinical, on humans) done by a university (a private one). There are big studies that enrolled hundreds when not thousands of people done by universities around the world. The hospital I am being treated by is a centre of excellence at european level, it is public and it has 155 clinical trials going on at the moment. Some in partnership with big pharma, some are their own discoveries instead.
About my expression "making noise", yes...for AOH1996 which in my opinion has been largely oversold by the media, tonnes of "ink" has been spent...for something that theoretically can target 70 solid tumors (only on cells and some mice for now), look for it on Google. And you think there would be no newspapers, online, printed and so on, that would make at least half of that noise for something that works?
Big pharma is not the big brother that can control all blogs, all the media at all levels, everywhere in the world.
Not to mention that Big Pharma was like 7 companies 40 years ago, now biotech, medtech, genetic editing companies are thousands because 3 students with a good idea and a mid size budget have the the computational power to do something good.
I am not saying that there are not big bastards in pharma business, there are many, and they are there to make money, and in the past they have hidden stuff for profit..I am just saying that nowadays the magnitude of control that would be needed to block information of this importance (we are talking about a cure for advanced PCa) would be NSA level, not big pharma, and I think you would not find those research on a public database if it was the case.
Wow I didn’t know it was that extensive, sounds promising, and yes I was hoping the blogs would keep a lot of the biased info out n vice versa. I was in the dental 🦷 field for 29 years and know how pharma n the reps really push the most expensive product but not necessarily the best. I’m really discouraged how they’re pushing adt and we all know that’s not the cure instead of really pushing studies on ivermectin, the antiviral drug you mentioned yesterday(marcylovir I think it was) among the quite a few others. But nonetheless thank you for explaining how many hundreds/thousands of studies are being done, and I know there’s a cure out there for most of these cancers … keep posting n informing, really appreciate your posts…
I have worked for 4 years only in public health system here. It has always been a battle between pure research and pharma, they keep each other in check. But health systems are now more than ever trying to repurpose drugs. They are helped by AI and they know that it’s a faster process because those medicines are already approved. I am honestly worried about when I will become CR, and I am really thinking about making noise about that UoM research.
Well hopefully you won’t become CR but if you do there is quite a bit of evidence that ivermectin can reverse that if you choose to continue to go adt route. Like that your also taking curcurmin and cbd oil in your regiment as it seems to be working well for me…
It’s always hard to keep balance between reality/realistic hope and real unlimited hope. But fighting one disease is enough, so I try at least to get nothing else to worry about. Then if what I take does not hurt SoC (in my case I mean taxane chemo as I have read nothing linking curcumin to decreased time to castration resistance) and gives me even only a 1% efficacy probability against my cancer, why not? 😊
We can always try, we put 100 USD each on an account and use it to make noise with a petition on Change.org or something like that, we send it also to local news websites and we address it to the UoM, this way we can help them to raise public funds for a research that will save many men and that costs 1/100th if not less of what SoC costs at the moment.
I will start the petition myself, anyone is interested in giving me an opinion on the "message" (of course I am not a native English speaker) and is there anyone wanting to help to spread the petition on here but also in the outside world???
a pity that I am metastatic and high volume...but that was a clinical trial done by a university with no external funding and published by a reputable journal which, by your parameters, should have never published this
Yes I know about fiduciary stock guys are always trying to convince me of their altruism but I rarely see it done w these effective low priced drugs and or supplements…js
"Effective low priced drugs and or supplements"... effective for prostate cancer?Taking yourself out of the equation ( bias should always be avoided), what studies have shown effectiveness for prostate cancer?
Stock guys typically don't act as a fiduciary, financial advisors do and I doubt perform their activities in an altruistic manner.
The never ending conspiracy that patients are kept from treatments never ceases to amaze me.
I worked in the pharma industry and my wife currently works for a CRO that does a ton of clinical trial work...all phases....I have a brother ( Phd chemist) who worked for Merk, BMS and MSK. I see Maxone73 combing thru the research sites and posting all sorts of interesting articles...do you honestly believe he or any other other HU member (me included) can understand most of that lingo?Sometimes I just shake my head in bewilderment on what gets posted on this site....
Answer this question...if this repurposing of medications is as effective as you claim why do China, Russia, Noth Korea and India work so hard to steal our current pharma advances when cheaper non IP protected meds are available?
They are doing both to be honest. Trying to steal and also research on repurposing. And China is the most advanced in gene editing at the moment (they have much less restrictions there…I wonder how they recruit volunteers!). I also come from a medical/radiology environment 😊 even if my research path is different and software/mathematics oriented.
I'm a software engineer with a BS in Physics, and a MS Comp Sci. I mainly do cloud development right now..ansible, gitlab pipelines, kubernetes and helm charts and AWS, Elasticsearch, Logstash, Kibana development. However, I keep my developer skills tuned and I'm currently taking a Online classes on AI and Statistics. I using Jupyter Notebooks to develop and train the algorithms and eventually deploying in golang. Not sure what sw tools I will use in the end. My interest is in options trading and I use elasticsearch to collect the data. Writing the ML to process the data and correlate with SEC filings, news articles, etc.
It’s not because of adt, the diagnosis itself killed me somehow. I am restarting now to do some work but trying to switch to something less stressful than my research (GANN and LSTM neural networks applied to music) like teaching math or coding.
The initial diagnosis was a gut punch for sure...some deep depression set in. My wife suggested I get on a anti depressant and I did...10mg of Lexapro. Now I'm rarely depressed. I could probably come off it but they're hard to wean off. I still work FT and generally like my job..very little stress with a pretty decent salary which affords me the ability to travel. I think I showed you a few pics of my trip to the Dolomites. Next year is Paris for the Olympics and hiking in the Pyrenees. A few gravel bike races and another attempt to ride up Mt Washington, NH. Who has time to think about cancer?
Yes you showed me some great pics. I hope I will reach that attitude! I am only taking melatonin and something more chemical to sleep for now. Needing it less and less luckily, but I will keep melatonin.
Well I can’t speak for those countries other than they are known for trying to steal everything we do but as far as maxones post they are very interesting and most of the time if you just read the conclusion it breaks it down in somewhat layman’s terms. No disrespect to you n your family that are in pharma but big pharma has a bad reputation for manipulating which studies get done and for pushing their drugs…
If you want to treat yourself as a lab rat,, that's your prerogative. The conclusion you allude to..if it were only that simple, you have no idea if that conclusion is correct. You better understand how the study was conducted, the data generated and the methods used to collect and analyze the data before you rely on the study conclusions to guide your treatment decisions.
Studies that are manipulated are the studies that produce results....not the studies we wish to succeed, but the studies that do succeed.
Lab rat, n=1, whatever you want to call it, what I do know is ivermectin has been used over a billion times w virtually no side effects. If that’s not proof enough that it’s safe then that’s just straight naive. As far as analyzing the results these studies come from, pub med (nih) seem to b very thorough and the conclusion is easy to understand after reading the article…
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