Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application

[pca2004]

New paper offers a nice review of why one might use melatonin against PCa. Section 3 lists ten reasons. [1]

19 years ago, the Life Extension PCa protocol included 40 mg melatonin before bed. After a few years, this was increased to 50 mg. I'm still on it.

-Patrick

[1] full text:

aginganddisease.org/EN/10.1...

[CurrentSEO]

Patrick thanks for this. I'm between on 20mg and 60mg as well mostly. However one things to keep in mind these doses increasing prolactin level... mine is above normal when not on ADT, so cabergoline helps

[pca2004 in reply to CurrentSEO]

Thanks!

[Kuanyin]

Hi Patrick. You have been writing about Melatonin for years. I believe you once said that you take 60mg. I have been taking 40mg. I came across an article several months ago which I have intended to post claiming that there is a distinction between the natural vs artificial forms of the hormone. I remember years ago there was a controversy over right-sided and left-sided molecules of Vitamin E. It seems that the "right-sided" molecules were more absorbent than the "left-sided" ones. With this in mind I am citing a report on naturally derived melatonin.

--K.

Melatonin—More Than a Hormone for Sleep Is Phytomelatonin Complex Better Than Synthetic Melatonin? The Assessment of the Antiradical and Anti-Inflammatory Properties

Comparative Study Molecules. 2021 Oct 8;26(19):6087. doi: 10.3390/molecules2619

Wirginia Kukula-Koch 1, Dominik Szwajgier 2, Katarzyna Gaweł-Bęben 3, Marcelina Strzępek-Gomółka 3, Kazimierz Głowniak 3, Henry O Meissner 4

Abstract

This work aims to assess the recently established anti-inflammatory and antioxidant potential of melatonin of plant origin extracted from the plant matrix as a phytomelatonin complex (PHT-MLT), and compare its activity with synthetic melatonin (SNT-MLT) when used on its own or with vitamin C. For this purpose, a COX-2 enzyme inhibitory activity test, an antiradical activity in vitro and on cell lines assays, was performed on both PHT-MLT and SNT-MLT products. COX-2 inhibitory activity of PHT-MLT was found to be ca. 6.5 times stronger than that of SNT-MLT (43.3% and 6.7% enzyme inhibition, equivalent to the activity of acetylsalicylic acid in conc. 30.3 ± 0.2 and 12.0 ± 0.3 mg/mL, respectively). Higher antiradical potential and COX-2 inhibitory properties of PHT-MLT could be explained by the presence of additional naturally occurring constituents in alfalfa, chlorella, and rice, which were clearly visible on the HPLC-ESI-QTOF-MS fingerprint. The antiradical properties of PHT-MLT determined in the DPPH test (IC50 of 21.6 ± 1 mg of powder/mL) were found to originate from the presence of other metabolites in the 50% EtOH extract while SNT-MLT was found to be inactive under the applied testing conditions. However, the antioxidant studies on HaCaT keratinocytes stimulated with H2O2 revealed a noticeable activity in all samples. The presence of PHT-MLT (12.5, 25 and 50 µg/mL) and vitamin C (12.5, 25 and 50 µg/mL) in the H2O2-pretreated HaCaT keratinocytes protected the cells from generating reactive oxygen species. This observation confirms that MLT-containing samples affect the intracellular production of enzymes and neutralize the free radicals. Presented results indicated that MLT-containing products in combination with Vitamin C dosage are worth to be considered as a preventive alternative in the therapy of various diseases in the etiopathogenesis, of which radical and inflammatory mechanisms play an important role.

[pca2004 in reply to Kuanyin]

Hi Kuanyin,

For many years I bought only Life Extension's [LEF] 10 mg melatonin (I take 5 before bed). But Swanson sells a much cheaper version & it is also always sold as a BOGO. Surely, melatonin is melatonin? & I go through 150 each month.

My son swears that the Swanson product is ineffective for him - he will only use the LEF.

It seems that he might be correct.

When you Google natural versus synthetic, the former is defined as being derived from the pineal gland of an animal, & is not recommended (if you can even find a brand that does that.) So PHT-MLT is synthetic too.

LEF says that theirs is "vegetarian" - thus, PHT-MLT; Swanson doesn't specify.

I notice no difference. I sleep easily regardless. But I will return to LEF.

Thanks for the heads-up - very useful.

-Patrick