Greetings FPC members,
As some of you know, I believe that the development of a vaccine or vaccines is crucial to developing a cure for PCa and certainly for achieving longer remissions. Activation of our immune system is the key. We have seen the development of Provenge which has proven useful for some and less so for others. The APCEDEN vaccine is being given in India and a gentleman on another forum had fantastic results with use of it over several years ( see posts by Fuzzman77 in Advanced Prostate Cancer ). So where are we at today in finding a vaccine?? I will try and cover recent developments as well as clinical trials that are ongoing.
In a meeting this year of the American Association of Cancer Research, a case presentation of using a combination of cryosurgical tumor lysis followed by intratumoral immunotherapy resulted in a durable response for both MHSPC and MCRPC patients. See below:
abstractsonline.com/pp8/#!/...
Next, a vaccine comprised of human antibodies fused with tumour-specific protein intended to target the cancer as well as activating the memory of the tumour cells.
sciencedaily.com/releases/2...
The science article for the heavy hitters:
onlinelibrary.wiley.com/doi...
Third, some vaccine clinical trials in progress:
cancer.gov/about-cancer/tre...
cancer.gov/about-cancer/tre...
cancer.gov/about-cancer/tre...
cancer.gov/about-cancer/tre...
cancer.gov/about-cancer/tre...
cancer.gov/about-cancer/tre...
cancer.gov/about-cancer/tre...
There are more that I am aware of in process by companies such as Advaxis with 2 vaccine candidates--ADXS PSA- see below:
advaxis.com/psa-associated-...
and ADXS 504 starting Phase 1:
prostatecancernewstoday.com...
The Science is Coming, so let us have... HOPE !!!
Don Pescado
DISCLAIMER: I can not guarantee that I have covered all vaccines in development or on trial as the list goes beyond this I am sure...