Update on Prostate Cancer Vaccines from Previous Posts done over the last few years... and a new one...

[NPfisherman]

Hello FPC forum,

So after messaging with Soumen79, I realized that this was overdue...

Over the last few years, I posted a series of articles on prostate cancer vaccine candidates, what I felt was their potential, and relevant information from clinical data. I thought it might be time to give an update and see what has happened in 1 year.

Let's begin with RV001, which I felt had great potential for PCa sufferers. Rhovac has now completed Phase IIb, and the study evaluated this treatment in more than 175 patients and released data. The data was not favorable:

fiercebiotech.com/biotech/r...

Next, I posted on Advaxis, a company with 2 PCa vaccine candidates-- ADXS-PSA and ADXS-504 ( a neoantigen vaccine-off the shelf).:

At this point, ADXS-PSA has not yet announced Phase III trial despite positive phase II results. There is an announcement of the initial Phase I trial results for ADXS-504 as below:

advaxis.com/news-releases/n...

I think that an off the shelf vaccine sequenced properly with other therapies might have a real show stopping effect on PCa.

Next, my post on the 2 vaccine brothers being done at University of Wisconsin:

healthunlocked.com/fight-pr...

and the trial itself:

clinicaltrials.gov/ct2/show...

The estimated primary completion date is pushed back into 2023. For those that have MCRPC, this trial is open enrollment for 60 volunteers initially. Locations are in Wisconsin and Missouri...

Lastly, there is the new kid on the block.. OVM-200. This has been posted on by Brysonal on this forum:

healthunlocked.com/fight-pr...

Some more info:

dailymail.co.uk/health/arti...

Treatment alternatives continue to evolve as The Science is Coming !!

C'mon Mother Science and Father Christmas....

Don Pescado

[cesces]

Thank you so much

[NPfisherman in reply to cesces]

You're welcome...

[GreenStreet]

Thanks very much for pulling this all together let’s hope at least one of these comes through. I have a feeling I will be back to treatment in the New Year and so am looking at all options. I hope things are working out well for Brysonal

[Brysonal in reply to GreenStreet]

All good - just a busy week. No side effects from jab 1 so far! Back in two weeks fit second increased dose if again my medical status clears. I was back to work Friday but chilled weekend!

[cujoe in reply to Brysonal]

I just read through the selection routine and acceptance to the trial by Brysonal in the earlier post on OVM-200. He is definitely our man on the street for OVM-200. Brave man taking chances for all of us here and elsewhere. Thank you, Sir! - for your service to our common cause and for so willingly sharing your experience in such detail. May your outcome be an excellent one. Ciao - K9 Terror

[NPfisherman in reply to cujoe]

K9 Wonder,

Indeed, we appreciate all that participate in trials, and those that try to participate in trials. I didn't hear yet from the OVM 200 trial contact yet, but who knows...a trip to jolly old England may be in my future. This trial allows people on ADT to participate as opposed to ADSX-504 that insists on no ADT... Hope all goes well with you...

Be safe and Be well,

DD

[GreenStreet in reply to Brysonal]

Great to hear and can I add my thanks to you too. Very brave and very generous in sharing the experience of the journey

[Brysonal in reply to GreenStreet]

No need for thanks. I not so brave.. those doing the phase 1 C-ArT and Bite trials and intermittent HT are truly brave.

With this vaccine one they are letting me stay in my HT and as only 5 months undetectable I wouldn’t be brave enough to come off it Maybe July 23 at my one year point and maybe if I get a T cell / immune response to the vaccine it will bolster my bravery.

For now I remember being told I had metastatic spread to the spine at T1, T2, T3, T4, T5, third rib, shoulder blade, L4 and others so know I’m incredibly lucky to have been able to access treatments that pioneers have trialled that allow me to be NED today.

Next OVM 200 shot is a higher dose of course but we need the science to keep pushing forward as we know with PCa NED today at at stage 4 is pretty well always temporary with the rare exception such as Gourd Dancer who of course did a really tough clinical trial and scored a jackpot!

[GreenStreet in reply to Brysonal]

you deserve the jackpot imho 👍🤞

[NPfisherman in reply to Brysonal]

I agree with Green Street on all counts.. brave, generous, and deserving a jackpot... kudos to you...

[NPfisherman in reply to GreenStreet]

Glad to keep updating the continued effort to find a vaccine for PCa. I also hope things continue to go well for Brysonal and the vaccine is effective. We need something more than current SOC for people dealt the tough hand of multiple metastases from the beginning.

Fish 🐠

[NPfisherman in reply to GreenStreet]

Sorry to hear that you may be back on tx, and I can say it is not better the second time around, but no worse. Brysonal is doing well, and keeping us informed. I think one or more may go through. This is what we need... something beyond AR drugs...something to stop metastases...

Fish 🐠

[Soumen79]

Hi Dave,

Here in India, in our divine saga of epic Ramayana, a little mouse did help lord Rama to build his bridge over the great ocean by only bringing few small stones and however small his efforts are, its still revered. Your mentioning of my name in your great effort reminds me that story of a mouse.

Thank you so much for the article.

Cheers for Brysonal and jolly old England may again come up with an answer, as far as I know abi was from that place.

With Regards

Soumen

[NPfisherman in reply to Soumen79]

Soumen,

If someone inspires me in a positive manner to write a post, then I like to let everyone on the forum know where I got it. Well, there is one more post coming on cellular immunotherapy treatments in treating PCa that is in process... more tomorrow...

Dave

[Fash01 in reply to NPfisherman]

Good evening from Hawaii gents! I’m so grateful for folks like NPfisherman etal,

Thank you thank you thank you!

[NPfisherman in reply to Fash01]

You are most welcome. We are starting to have more contribute on the forum, and I am glad to see more put out their thoughts, new science developments, etc... This is a hard journey. Everyone operates at their level of comfort.

Fish 🐠

[Brysonal in reply to NPfisherman]

This is my favourite forum for its beyond SOC ‘follow the science of the future’ focus and helpful, polite and supportive membership.

[NPfisherman in reply to Brysonal]

Thank you for saying that about the Fight Prostate Cancer forum..The forum has changed over the years, and I think that cujoe will confirm what I say... more members, more posters, more science, and not limited in scope of discussion... and yes...polite, supportive, helpful...

One poster on another forum insinuated that I was giving people "false hope" with my science articles. I disagree... I believe our " follow the science of the future" approach gives members a chance to see what is under development, discuss the potential, and develop a plan on how to deal with their cancer by incorporating knowledge (SOC and other) found here.

It may not be "moderated", but it is a great forum in my opinion...

Dangerous Dave

[GeorgeGlass in reply to NPfisherman]

I'm coming over here to get away from the censorship members over there on APC. The entire point of these sites are to learn about alternate ideas. If someone just wants to hear about SOC, they can get that from their doctor. If they want static posts and lectures, they can go to PCF.org etc.

[Cooolone]

Thank you for posting!

[NPfisherman in reply to Cooolone]

You are most welcome... I have a number of posts on new developments that need an update. I'll try and get to it over the next few weeks.

[MateoBeach]

Thanks for this update, Don Pescado.

Just want to remind everyone not to forget about Provenge (Sipuleucel-T) the only proven and FDA approved immunotherapy for APC. Real world results show a greater than 12 month longer overall and progression free survival, despite only a few months increase in the initial clinical trials. For that reason it is often ignored and greatly underutilized.

That, and the financial toxicity if it is not covered! Get it if you can and get it early. It has not been formally tested in HSPC, but might work even better.

[cujoe in reply to MateoBeach]

What's up Doc? Just wondering what would be the minimum testing needed to be in-the-ball-park for appropriate consideration of posssible Provenge efficacy? Cabo sunny side up, Please. S&W -ciao K9 (BTW, early-birder, had your coffee yet?)

[MateoBeach in reply to cujoe]

My view is that once it is shown that a treatment can have even a small improvement in survival or progression in the very advanced, highly pre-treated mCRPC, basically end stage disease. It is like the arrow’s span of flight was deflected by an intervention very close to the end. So it is possible (perhaps likely?) that if you were to use it to provide some deflection of the trajectory earlier, then even a small deflection could produce a larger effect on the overall “flight path”.

Provenge added 4 months in the original mCRPC trial in very late stage disease. And over a year in more diverse “real world” analysis. No reason not to reason that it could be even more effective given earlier, say at BCR or HSPC. It depends on PC antigen presence, not hormone status. There is a current trial underway using in Active Surveillance patients. None for mHSPC. And the out of pocket cost to buy it is astronomical. Darn it.

[cujoe in reply to MateoBeach]

The deflection (small late vs large earlier) is a very good anolog for consideration of efficacy. All that warm, sunny weather is obviously not affecting that big brain of yours. Thanks for the insight. Keep it S&W - K9

[NPfisherman in reply to cujoe]

K9 Terror,

I like Pablo el Medico's arrow deflection analogy as well, and think it quite accurate. Look at abiraterone, used initially for MCRPC, but under a STAMPEDE trial, it was shown that early usage in MHSPC resulted in delayed castrate resistance and prolonged OS. Maybe, I will do an experiment and see if going to Cabo makes me come up with very appropriate analogies, and if not... it will enhance my tan... and I can do some fishing...

DD

[GeorgeGlass in reply to MateoBeach]

good analogy Paul, I agree with you. I'm still working to get my provenge. The industry seems to feel strongly, that provenge should be used after 2nd line AR fails, and metastatic is "proved by scans"

[Brysonal in reply to MateoBeach]

Great reminder. I do watch it but wonder why it’s only available when castrate resistant? I really would like to avoid getting to that point so OVM-200 interested me for that reason too.

Provenge is interesting for the castrate resistant but for me hormone sensitive I don’t think it’s an option?

Good to have still on table though!

[NPfisherman in reply to Brysonal]

Brysonal,

My thoughts exactly on why I am looking at OVM-200. Something to get my immune system a boost.

Good luck, my man...

Fish 🐠

[NPfisherman in reply to MateoBeach]

Pablo,

I am working on a post about T cell therapies and hope to get it out later today. Indeed, Provenge is crazy expensive, and I do wonder how BiTE would do if given early. I realize most new therapies are aimed at MCRPC, so the castrate sensitive wait.. It took years for abiraterone to be approved for MHSPC. Would earlier tx with immunotherapy change OS?? I think it likely...

DD

[NPfisherman in reply to MateoBeach]

You are most welcome, El Rey de Cabo...

I liked the arrow path analogy, and agree that Provenge is just crazy expensive. I find it interesting that APCEDEN is using circulating tumor cells in making their vaccine if no tumors are available for lysate. APCEDEN needs more PCa clinical trial evidence to prove worth and not just Fuzzman77's story... They should be taking all patients for 2 years treated for PCa, broken down by MHSPC vs MCRPC and track their progress. This would also help validate the treatment value...

DD