Total fertilisation failure ICSI

[MollyHar]

We are absolutely devastated to find out today that we have had total fertilisation failure with our 5 eggs and ICSI.

How is this possible? I am finding it difficult to come to terms with.

Our first round we got 7 eggs and 100% fertilisation.

They upped my stims this round from 225 ovaleap to 300 menopur. My AMH is good for my age at 18.6, 39yrs, and its male factor infertility. I was on the long protocol and was always dubious about the ramp up in stims...

Our follow up appt isnt until weeks away and I just feel lost and in the dark.

Has anyone experienced this rare outcome?

[Elsidee11]

hi MollyHar - so so sorry to hear. I just replied to Dragonfly1111 as this happened to me during my second round, we had total fertilisation failure with icsi. They were able to inject 4 eggs but they just didn’t fertilise, husbands DNA fragmentation test was normal.

At the time, my consultant said it was due to poor egg quality, however I got a second opinion at another clinic who said I was stimmed too high (375 Ovaleap) - so I did a third round with the new clinic changing protocol and lowering my stim dosage and had a much better response.

every cycle is different and although TFF is so hard to deal with at the time, you can go on to having a successful round after. Sending lots of love x

[Elsidee11 in reply to Elsidee11]

If you scroll the feed, I also tagged dragonfly in my post from 11 months ago, there’s lots of responses - you may find useful x

[SarahHit]

So sorry this happened. when we tried ICSI - my eggs died on injection. We've since reverted back to IVF and had much better results. I know there is a sperm issue but have you ever thought of trying half IVF and half ICSI? It's all trial and error, so hard to know what is the best way forward

[MollyHar in reply to SarahHit]

Hi Sarah. I don’t think we can have IVF as we are working with frozen sperm. I will ask the question on review. Thanks for your message x

[leo1980]

hi. Just wanted to say we had this too! I was also the same age (39) at the time and we have morphology issues. (Male factor)

It was soul destroying . We did subsequent rounds same protocol and it results were different. Don’t give up

[Onlydecaf]

so sorry to hear this, we found out yesterday that none of ours fertilised normally with icsi- our second round. I didn’t respond very well to stims this time and so only 3 injectable eggs, but it still floored me to hear that it’s all over. it really really sucks and I’m so sorry you’re going through it too! X