Just wanted to let you know that my perfect pgs tested hatching blastocyst just didn't want to stick around. I tested 10dp5dt, 11dp5dt and today 12dp5dt. I'm OTD is tomorrow but I know it will continue to be a BFN.
Everytime I keep telling myself I'll be tough and I'll be ok, but it is heartbreaking. And I actually let myself have hope and be positive this round. I'd never had such a perfect embryo transferred.
Clearly there is something wrong with me.
I still have 2 PGS tested frozen embryos but before I risk putting anymore back I want to make sure that we have everything covered to support implantation.
Can anyone share experience or recommendations on what to talk to my clinical team about next- ERA NK cells???
Keeping fingers crossed for everyone else in their TWW and holding out for a BFP this week
Xxx
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I don't have any advice with regards to the ERA NK cells, but I just wanted to say how sorry I am to read this. I was following your journey and really hoping this time would be it. Sending you lots of light and I'm glad that you've garnered the strength to move forward and tweak your clinic's approach.
thank you, it means a lot. I think Im going to get a second opinion on whatever treatment plan my clinic recommends. I'm 41 and time isnt on my side and everything just takes so long! At least I know the problem isnt my embryos xx
Totally understand how you feel. I'm 41 as well. After my first two FET cycles were cancelled, I also got a second opinion and then took it back to my clinic and demanded that they consider the suggested protocol. Hang in there, your time will come!
So sorry to hear this, the ERA test for me showed I needed an extra 12 hours of progesterone - I’m just in my tww so not sure if it’s helped this time.
I so upset for you lovely. Sending you virtual hugs...I did the NK test. It’s about £1800 and takes about 2 weeks to get the results. The treatment is standard. A course of intralipds, steroids and blood thinners. Worth looking into...
thank you lovely - and thats good to know. I'll definitely look into that. Im at the point now where I'd just rather throw everything at it than have to start again x
I'm really sorry to hear this - it's an absolutely s*** journey isn't it. My ERA showed that I need 24 hours extra progesterone so I'm hoping with this change it'll be our turn.... might be worth thinking about. I'm thinking of getting my NK cells & Cytokines tested too but at the moment our clinic won't give out steroids so there's little point. xxx
First and foremost STOP saying that is something wrong with you as I will get upset 😂😁. It is nothing that we do purposely so therefore is not our fault that we are in this situation. I had 2 fresh transfers that ended in chemicals and we decided to PGS test our embryos on next round, we did a FET in Nov with a PGS normal embryo and guess what the same result, another chemical pregnancy, so I understand perfectly what you feel now. We also have 2 more normal embryos and 1 mosaic on ice. Since Nov I started to do lots of tests: hysteroscopy (which I advice you to do first), ERA I did before FET and came back normal receptive, NK cells, thrombophilia screening, Thyroid antibody, CD138 for Endometritis (not endometriosis) and lots of genetic tests. I found few issues that we are corecting them now before moving into next transfer. You can mention them to your clinic as well see what they have to say. I am really sorry that transfer didn't work this time 😔 stay strong 💪🤗
Thats really insightful Ranchu90, thank you. Hope it all helps with your next transfer.I'm sure I'll be feeling more positive tomorrow - its such a rubbish journey isnt it!
In the meantime I'm definitely having a large glass of wine tonight!
Hi, I’m so sorry to hear you had a negative this time. One thing to consider is asking your clinic to do ‘failed implantation’ testing. We had 1 failed fresh and 1 failed frozen - great embryos and great lining. I insisted we do the test before starting my next stims round. The consultant said it’s not normally offered until 3 failed transfers, but I was having it! Something showed up with my antinuclear antibodies, I got medication that started same day as my stims cycle and I just got my BFP. I’m 40.
I’m not suggesting it will be the same for you of course, but that cost £500 plus cost of medication and was straightforward bloods that checked all sorts of things like thyroid, NK cells etc. It wasn’t a biopsy or anything like an ERA - so do find out if your clinic offer it.
All the best with your next steps, I hope you are being gentle and easy with yourself.
That’s really encouraging!! That’s what I love about this group is that not only do we have amazing support but we learn from each other - and what to ask our clinics about.
I’m so happy for your BFP. Massive congratulations 💕
Exactly! I didn’t even know about this test - I suggested ERA to my consultant after reading others here sharing about it and he suggested we try this first. I think ERA’s are expensive and invasive and of course that may be the necessary route but good to hear of other possibilities.
I also think it’s good for your heart and mind to be focusing on what’s ahead and getting repurposed for next cycle.
I'm sorry to hear this and I know the feeling. Please get yourself together and keep being hopeful. ❤️🙏One day when you become a mom, you'll look back on this day and give a huge grin. Xx
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2 chemical..3rd now is PGS worth it??
Anyone had faint positive at 12dp5dt and still had successful pregnancy?
Success stories with 2 PGS normal embryos?
