I'm just wondering how sensible we are being. I am 41 and have had 3 miscarriages so far and one BFN and now one current BFP. This is after our first 2 cycles having no transfers due to PGS all testing aneuploid our 7 embryos. Then the next 2 cycles we skipped PGS testing.
My husband and I are trying to decide how to proceed with our next 2 cycle plan. Whether we should PGS test or not. It would be our final tries with my eggs. And I suppose it would remove all the miscarriages and give us our answer right away whether any of these pregnancies would work out.
Just want to know if there are any other over 40s that aren't doing PGS and have had multiple miscarriages?
Of course I am still hopeful this current BFP will be our miracle, I have just been through alot with this IVF journey.
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Violet180
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I had 2 natural pregnancies at 38 and 40 which both ended in miscarriages before 8 weeks. I then had IVF at 41 which resulted in my son. We didn't bother with PGS with the successful pregnancy but my clinic found that I had sticky blood before our cycle started and put me on Innohep so I'm guessing that was the issue in our case. Wishing you all the best. 🙏❤️xx
Violet180 Me too. I was literally at breaking point when I went to my clinic. My NHS fertility clinic made me feel like as I was over 35 it would never happen! I know it's harder for us older ones but it's by no means impossible. 💖💖xx
I don't remember off the top of my head but think it's one of the more basic tests as the more pricey ones found nothing . If I can find my paperwork I will have a look & let you know. xc
I am with rainbow on this. Probably best to get tested. If you have had miscarriages either from normal or ivf preg- the uterus does develop antibiotics which often goes undetected. This prevents implantatio/successful pregnancy. I am nearly your age and my dr explained PGS testing like a soccer ⚽️ if you rest from the white you may get one answer if you test from the black you get another! We have not done the testing on any of my two cycles. We assume because of advanced age 😮 my eggs would be 70% abnormal anyway. I have no baby though. I am looking into further testing before I transfer my Frosties which I have from 2 years ago. Best of luck.
I don’t know if this helps because I found out early on into my ivf journey that my eggs had less than a 2% chance of working. That was over a year ago and I’m 40 now. We’ve moved on to donor eggs but the first attempt failed because the donor’s egg embryos arrested in development before day 5. So we had nothing to transfer. Seeing as we had already spent so much money at this point our Donor coordinator recommended PGS/PGA testing on the second donor attempt to save us time, money and anguish. I was unsure at first as it was yet again more money but in hindsight I am so glad we chose to do it. Our second donor produced 11 eggs, 5 fertilised and 2 made it to blastocyst stage. One was good quality, the second was average. Both were tested and came back normal. I haven’t had the transfer yet but our doctor has said if we hadn’t had them tested he would have transferred both which then increases the risk of twin pregnancy. Initially I thought twins would be great, but after reading the stats and associates risks I’ve changed my mind. So now knowing they are both normal means we will transfer one at a time and the odds of a successful pregnancy have suddenly shot up. Now we need to ensure my uterine lining is good, that my uterus is clear and that my prolactin, tsh and T4 blood levels are all ok as at this stage a miscarriage would not likely be due to a fault with the embryos but rather it would be due to me. Also, the average quality embryo rating has become irrelevant because once they are PGS tested normal it levels the playing field and it’s considered as good as a top grade embryo.
But obviously none of this will be relevant to you because this round is going to work! It’s great you identified the sticky blood thing (I had no idea about that and am going to google it now). Take care of yourself xx
I have never had my thyroid tested.....maybe I should do that. I dont seem to have a problem getting pregnant from transfers and the embryo quality is generally pretty good. That's why my RE believes its a chromosomal thing due to age and just a matter of finding a normal embryo. But maybe I will only get 1 in 20 embryos that is normal and how long can I try really. This was my 13th and 14th embryo.
Because of my history I am not really concerned with multiples. I would love it at this point. And it is VERY unlikely with me.
I had 3 miscarriages from natural conception over a 10 month period aged 41 (one was tested and had a genetic problem other two not tested). I then went on to have IVF at 42 years old, we opted not to have PGS testing done (clinic wasn't happy) but I was prepared to try every embryo we got! In our case we were very lucky and I got pregnant first time and he is due in 6 weeks time.
I read about a doctor in the US who started to put some of the mosaic embryo's back in and some women went on the have healthy babies! My clinic would not consider putting mosaic one's back so that's what swayed us not to test. However as you will know having repeated miscarriages is absolutely sole destroying so it is not an easy decision to make.
I had human growth hormone during my IVF (not sure if this is a commonly offered in all clinics) but due to my age I reckon this my have help us, although I have absolutely no proof of this!
Keeping my fingers crossed for you that your current embryo stays put and that you don't have to make the decision, good luck x
Great to hear it worked out at 42. That's the same with my husband and I. We were absolutely prepared to test every embryo in the womb because we didn't want to discard any in the hopes they may work. I have read those same articles.
I guess we are reconsidering due to a time factor. (We are ready to be parents sooner than later and would fast forward these 2 rounds).
Hey. We are in a similar situation. We have just had our 3rd miscarriage in a row, all from natural conception. We have no issues that they can find, my AMH is really good for a 42 year old! All blood tests normal and sperm off the scale! My clinic isn’t willing to do any more tests as they just want me to crack on with IVF so We start IVF in the next few weeks with my next cycle and have chosen not to have the embryos tested despite our clinic pushing for either mapping or PGA. We are also going to try fresh transfer too. This is if we get some suitable embryos.
I get really frustrated that we get completely written off once we hit 40!
Everything crossed for us old girls!!! X
Hi Violet,
I’m 40, I’ve also had 3 miscarriages and started my first round 3 months after my 40th birthday. We did not do PGS and I had 7 eggs collected, 4 fertilised, 2 put back at day 5 resulting in one that stuck and I am now pregnant with a little girl 1st Dec. The other 2 unfortunately were not good enough to be frozen.
I’m in same boat, maybe bit older. Turned 43 and only have 2 grade 2 untested the other 2 are poor quality. Planning to go for round 3 and am very scared and devastated! No one knows what’s happening in their body .. I had molar pregnancy with chemo so my aim is to see if I can get tested one 🥺
So sorry Violet180 and everyone else on this thread who went through multiple MCs. My wife and I have a similar story if you look at our post from yesterday. I have a question for everyone though - when you had MC did any of you get to the point of a fetal heartbeat ? I feel like a miscarriage because of chromosomal abnormality largely happens before one can observe a fetal heartbeat but I have no basis to say that. Data says that the chances of MC after a fetal heartbeat is only 4%.
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