Down Regulation & Side Effects - Fertility Network UK

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Down Regulation & Side Effects


Hello All,

This is my first post ever, so a bit nervous.

I've been on my Buserilin for coming up 2 weeks on Thursday. Since starting it I have been feeling extremely tired and very emotional. Did anyone else feel like that?

I'm not sure if I'm emotional due to the Buserilin, or because I'm so tired, or because I'm so tired.

I'm a part of a large family and I'm struggling to watch people go about there daily lives as normal when nothing at all feels normal to me. It just makes me feel sad and angry.


8 Replies

Welcome 😁

I am on the long protocol and was like this when I was taking the contraceptive pill but seems to have disappeared since I started the buserilin injections (day 5)

I have had a few dizzy spells, cramping, bleeding and headaches but nothing too extreme.

Good luck for the rest of ur journey xx

Thanks Stacey.

I went straight onto the Buserilin, didn't have to take a contraceptive pill.

Hopefully it will subside soon, I could honestly fall asleep at my desk.

Good luck on the rest of your journey too xx

I suppose it does effect everyone differently.

I have been trying to go to bed quite early and even if am not falling asleep early I feel a bit less tired during the day and more relaxed 😌

I feel for you as there is nothing worse than feeling emotional and moody, my poor husband always ends up getting the backlash 🤦🏻‍♀️

I felt super tired when I down regulated too so its not just you! I eventually got headaches too....felt hungover really. However, once I got started on the stimulation drugs I felt much better! Oh and if you get headaches, avoid anti-inflammatory drugs like ibuprofen....only take paracetamol or if you need something strong you can take codeine. Good luck with it all!xx

Hey Cinderella,

Good to know I’m not the only one, haha told my husband how you described it as feeling like you’re hungover. He found that funny but definitely an accurate description.

I’m having Accupuncture alongside my treatment and luckily it managed to get rid of a 3 day long headache and hasn’t come back since.

I started stimulating today which is very exciting.

Thanks for writing back, good to feel like I’m not alone.

Hope all is going well for you x

Ha ha ha it honestly does feeling like a hangover which is ironic seeing as we're not even flipping allowed to drink! Glad to hear your headache has lifted, acupuncture does seem to help relieve the side effects. Exciting to me moving on to the next stage! Good luck for your scans!xx

Welcome to the forum! I felt exhausted on down reg and got the worst headaches which drinking lots of water helped with. Like Cinderella once I started stimming I felt better, lots of luck xx

Benita1986 in reply to E_05

Thanks E...feeling much better and not as depressed which makes the next stage a bit more exciting x

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