ICSI with PGD update

[Lizzielizzielizzie]

Many of you know that we are having ICSI with pre-implantation diagnosis in the hope of overcoming the low odds of having our own child naturally due to my husband’s balanced chromosome translation. It’s our third round of ivf but first with PGD.

I’m happy to say that, having had 13 eggs collected, we got six embryos of which we have had two embryos biopsied and frozen on day 5 and then two slowcoaches biopsied and frozen on day 6. The other two weren’t good enough quality to biopsy which probably means they were abnormal anyway.

We originally were given a one in six chance of creating a normal embryo, and we only had one blastocyst from both our previous rounds. So to get four is three times more than we expected to get.

There are still no guarantees that any of them will be normal and it’s a 2-3 week wait for the biopsy results to find out. They won’t let us transfer any abnormal embryos so we still have many hurdles to overcome. But it feels like progress!

Does anyone have any success stories about embryos that were frozen on day six due to being slow? I suspect being slow means they’re unlikely to be normal but I don’t know.

[WeeMrsH]

Brilliant progress so far Lizzie!! That’s so encouraging and positive. I’ve been thinking about you. 2-3 weeks wait, jeez, as if this process isn’t long enough. Have you got much on during that time to keep yourself distracted? I have zero patience... our clinic has only been donor searching for less than 2 weeks and already I’m like...hurry up!!! xx

[Lizzielizzielizzie in reply to WeeMrsH]

I’m not really finding the wait as hard as the usual 2ww. In someways I want the time to drag as I don’t want to get closer to bad news! Got a lot on at work so most of my worrying energy is going to that!

[Dunla]

Sounds like things are going in a really positive direction so far. Hoping so much you have good news back in 2-3 weeks time ❤️ x

[Hidden]

My embryologist said there isn’t much difference between Day 5 and day 6 blast success rates so don’t worry too much about that.

I recently had a day 5 and a better quality day 6 put back as FET and I’m now 11 weeks pregnant. No idea which one of them suck, but hopefully gives you some reassurance.

Fingers crossed for you both.

[Lizzielizzielizzie in reply to Hidden]

I’ve since read an article saying that day 6 blasts when frozen have similar success rates to day 5 so that’s good. Apparently they’re less successful if fresh as their development is out of sync with the development of the womb lining on a fresh day 6 transfer.

It’s all so incredibly clever.

[Cinderella5]

Ahhh this is great news Lizzie! Very pleased that you've had a better outcome than expected, long may that continue! No advice, just wishing you lots of luck for some good results....fingers crossed!xx

[Tugsgirl]

It’s been really interesting following your journey so far.. please keep us all posted xx

[Lizzielizzielizzie in reply to Tugsgirl]

It’s interesting living it too! Not fun, but always interesting. One day I’ll look back and wonder what all the fuss was about... hopefully whilst I’m watching my child sleep or making a family dinner. But in the meantime I keep posting as hopefully it will be helpful for others with the same problem... I’ve struggled to come across others who need PGD so I feel like we are doing it ‘blind’.

The support on this group always helps so much x