Implantation Problems

[MrsA29]

Hi. I'm new to the group and looking for some help please. I have just had another failed cycle of ivf using my last 2 frozen blastos ...this is the 8th time of trying for us. We got pregnant naturally 6 years ago but was ectopic, havnt conceived since. Had 8 rounds of ivf, last round we got 4 excellent quality blastos. Everything goes like clockwork until they are put back into my body but then nothing......had various tests done and all come back normal. Being treated by Dr Gazvani at Hewitt Fertility Liverpool (went there this year after numerous failed attempts on NHS at gateshead). I dont want to give up....there has to be a reason why its not working for us.....can anyone offer me any hope?

[Kattalex]

Hi, have you tried/considered the scratch or/glue?

[MrsA29 in reply to Kattalex]

Hi. Thanks for your reply. I have had the scratch a few times, didnt seem to make a difference. X

[Kattalex in reply to MrsA29]

Sorry to hear. 🙏

[LadyMM]

Hi

Sorry to hear this I totally feel you

Have you been tested for NK cell?

[MrsA29]

Hi. I had nk test done at Warwick last year. It came back as ok but it was odd as my lining was extremely thin which I've never had before. I had just had realky heavy bleed following failed ivf attempt and thought maybe the test had been done too soon....thinking of getting retested. X

[Wealth]

You might have adenomyosis. It can be diagnosed by MRI.

[MrsA29 in reply to Wealth]

Hi Wealth. I have just Googled that as was not sure what it is. I dont think it could be that as I usually have very light periods...apart from after failed ivf cycle when they are mega heavy! I will ask the question though. Xc

[Lizzielizzielizzie in reply to MrsA29]

Have you ever had a hysteroscopy, where they look at your womb?

[MrsA29 in reply to Lizzielizzielizzie]

Hi. Yes had it done and everything 'normal'. So frustrating....just dont seem to have any answers to why it isnt happening.x

[Amanda86]

Hello,

Welcome to the forum. I'm so sorry to hear all you've been through.

This may be of no use at all as I don't have the exact facts, sorry.

My friend, her partners dad and his new wife had IVF treatment in Spain. Their first round failed and I remember my friend telling me that the failure had been down to the implantation window? She said they ran some kind of tests, I don't know what exactly, but these tests picked up that her implantation window was slightly longer than others.

It was something like they discovered that for her it would be best to transfer the embryo on day 7, rather than day 5.

I'm not sure if this treatment was natural or medicated, but I know that she went with their advice and the second round was successful.

Sorry I can't be of much more help, if you like I could text my friend to get the full information regarding what the tests etc were.

Xxx

[MrsA29 in reply to Amanda86]

Hi amanda86. That sounds really interesting. Since my ectopic, I always ovulate late...like day 19 of my cycle, which when trying naturally on a 28 day cycle didn't seem to give enough time for implantation. This could be related in some way? Any more info you could get me would be very much appreciated. X

[Amanda86 in reply to MrsA29]

I will give my friend a text and get back to you 🙂

Hopefully this kind of testing could be helpful for you xxx

[MrsA29 in reply to Amanda86]

Thank you. X

[Hannah143]

HeyMrsA29 sounds like we are in the same boat, we moved to Donor eggs and still can’t get pregnant.

The test Amanda mentions is called ERA it tests your Implantation Window to test your most receptive time to transfer. I’ve had it done out in Spain , feels like a scratch.

I’ve been to see an independent specialist in Recurrent Implantation Failure as I wanted a second opinion.

For my final Donor embie that I have in the freezer in Spain he’s recommended the following:

Scratch the cycle before

Clexane - blood thinner

Steroids - to counter and Killer cells

Folic Acid

Transfer on progesterone + day 4 (which is when my Era test said I’m receptive)

I’ve had all of these things at some stage over my past 8 attempts but not all together on my Donor attempts so throwing everything at my next go.

Scratch due in Jan, transfer planned for first week in Feb.

I’m sorry I don’t have any answers for you, but you’re not alone. Have you tried the things above?

Xx

[MrsA29 in reply to Hannah143]

Hannah143 thank you for this information. Sounds like you have been through some very tough times. I was thinking about donor eggs too....I am waiting anxiously for follow up with consultant to discuss with him. Can i ask where you were treated in the UK please? What made you decide to go abroad?

[Nkoko]

Hi

I am 20 weeks plus pregnant after more than 15 tries! I had two miscarriages and no implantation on others. My consultant then concentrated on my lining. I did ERA to check if the lining is receptive ( transfer timing is correct) or post receptive (transfer done too late) or non receptive (lining not functioning) or pre receptive (transfer done too early). Go to: igenomix.com/tests/endometr...

This is the clinic my UK doctor sent my biopsy to. It is simply scraping of the lining after 6 days of progesterone. Also I have several multiple fabriods so I opted for a myomectomy. When both were done I went on a regime before the implantation, core of pineapple, raspberry leaf tea, Brazilian nuts and promograte juice. This worked! We are expecting our 2nd miracle after 10 years of trying!!!! I hope this helps!

[MrsA29 in reply to Nkoko]

Hi nkoko. Oh my word this sounds amazing. Thank you so much for this. I have lots of questions I would really like to ask you if you were willing? Am I able to send you a private email perhaps?

[alockie]

A friend of mine was in the same shoes, she simply combined IVF with PGS NGS, and it worked for her. She did it in top IVF clinic in Poland, cos she paid out of her pocket and it was much much cheaper.x

[MrsA29 in reply to alockie]

What is ngs please? Is this the genetic testing?

[Dreamydoran]

I soooo understand, we’ve had 13 failed attempts in succession, I think I’ve had every test under the sun except having my endrometrium tested for immunology (nk cell)

I researched immunology implantation dysfunction.. I will be having this hopefully in January with the possibility of then using prednisone with celexane and asprin..

it’s just a never ending roller coaster.. this is the final hurdle I think for us as there is nothing else they can test...

good luck

[Esme78]

I am sorry to hear about your difficult fertility journey Mrs A - do check this out with regards to implantation failure testing: uhcw.nhs.uk/miscarriage/nk-...