Beta Cell Destruction

[Pranam786]

Is sulfonylureas associated with progressive beta cell destruction if taken for a longer period of time?

[sandybrown]

Have a look at the link below:

diabetes.org.uk/guide-to-di...

[Activity2004 Administrator]

Have you read this article about c-peptides? It's on WebMD. webmd.com/diabetes/what-is-...

[shahzam]

No!

I am taking since from 25 years.

[Pranam786 in reply to shahzam]

Any side effects on kidney from sulfonylureas?

[shahzam in reply to Pranam786]

No thanks!

No any side effects on kidneys and liver.

ALHUMDULILLAH

I use gliclazide 80 mg twice a day.

[nyonyo in reply to shahzam]

Have you ever taken Homa B test?

[namaha Administrator]

Which Sulphonylurea are you taking?

Glyclazide clinical trials indicates fairly high level of safety with efficacy...

It appears in the WHO list of essential medicines...

The patented brand name is Diamicron MR...

This perhaps is the only Insulin secretagogues which is currently in use all over the world..it has never been banned by any country so far...

It was discovered in 1970 and in clinical practice since 1990....

However, please do consult your endochrinologist before making any change in your current medication...and you must check your blood circulating Insulin levels to see if this drug is required by you....

Also adopting suitable life style and dietary modification is of primary importance and these kind of drugs are only add ons and should be kept at minimal dosage level...

[Pranam786 in reply to namaha]

I am taking glyclazide

[namaha Administrator in reply to namaha]

Are you a thin type 2? Did you check for blood insulin levels before start of the medicine?

You should take it only if have low level of blood insulin!

If your blood insulin levels are high, there is no need of this drug...You can control your blood sugar level through Diet and exercise !

[Pranam786 in reply to namaha]

Yes I am a thin type 2 ..by the way fasting c peptide and fasting insulin level both are same??

[namaha Administrator]

It is a good question!

C peptide and serum insulin tests: Both are conducted to assess the beta cell status !

C-peptide and insulin are released from the pancreas at the same time and in about equal amounts. So a C-peptide test can show how much insulin your body is making. This test can be a good way to measure insulin levels because C-peptide tends to stay in the body longer than insulin.

However, there is a difference how both of them are eliminated from the body.. insulin eliminated by liver where as c peptide through kidney..

In case ones kidney is not efficient in eliminating c peptide from your blood, it may show higher reading of c peptide which may be mis-leading...

Therefore , it is better if we test both to assess beta cell status before starting any medicatíon..

[Pranam786]

My c peptide is 0.987.. what is normal level?

[namaha Administrator in reply to Pranam786]

Dear Pranam 786

What is the C- peptide unit of 0.987??

Anyway , for your reference :

The reference range of C-peptide is 0.8-3.1 ng/mL (conventional units), or 0.26-1.03 nmol/L (SI).

Some literatures indicate reference range as 0.5 ng/ ml to 2 ng/ ml.

In any case , assuming you had 0.9 ng/ ml, you appear to have low Insulin levels which you can reconfirm by another blood insulin test without drugs...

If the results are confirmed, continue with your prescribed medicines...keeping in mind that diet and exercise should be primary and medication only add on to keep blood sugar under control..

If your weight is less, also try to put up some weight so that you build more muscles with body cells to enable them to take up and clear the blood glucose level..

Wish you all the best ! 🙏

[Pranam786 in reply to namaha]

0.987 is more than 0.8 ng/ml than why are you saying that I have low insulin levels?

[namaha Administrator in reply to Pranam786]

Yes, it is towards the lower limit and you need to calculate the HOMA -B to see the beta cell status as per formulae as mentioned in my previous post!

HOMA B = (360XFI) ÷(FG-63)

[Pranam786 in reply to namaha]

What is HOMA B?

[namaha Administrator in reply to Pranam786]

It would indicate the Beta cell functioing status .. you may please read my previous post .

[Praveen55 Moderator in reply to Pranam786]

Pranam786

Fasting C-peptide level of less than 1 ng/ml is considered low . It is better to get tested for antibody to rule out the possibility of LADA or type 1.5 diabetes. I remember having mentioned this to you in the past because of your young age and healthy weight but still having diabetes.

Discuss this with your Doctor.

[Pranam786]

What's the name of the test to identify LADA?

[Praveen55 Moderator in reply to Pranam786]

It is combination of C-peptide and antibody test, called GAD antibody. Please follow the link below for more information on the subject:

medicalnewstoday.com/articl...

I suggest you should talk to your Doctor to avoid unnecessary confusion. Many a times LADA is misdiagnosed as type 2. This does not mean that you have LADA ( or type 1.5). Only after the test, it would be possible to confirm one way or the other.

[Pranam786 in reply to Praveen55]

Can we prevent Lada from happening?

[Praveen55 Moderator in reply to Pranam786]

Pranam786

May I suggest not to think too much on this before the test/talking to the Doctor. Current treatment of diabetes (type 1 and type 1.5/LADA) does not target autoimmune aspect of the disorder. Instead, it treats the resulting symptom of insulin shortage and its effects by providing the body with the insulin that it cannot produce itself.

People with LADA usually progress towards requiring external insulin earlier than people with type 2 diabetes. Having the knowledge of the condition helps to provide right treatment when required.