Why People with Type 1 Have Digestive Problems

Why People with Type 1 Have Digestive Problems

Here is an article I found on-line. Thought it was interesting and useful to read. Please check it out. It was written by Travis Manni.

Why People with Type 1 Have Digestive Problems

Researchers discover a possible root cause of multiple digestive issues in people with diabetes.

Travis Manni | February 11th 2016

The longer a person lives with diabetes, the higher their risk of digestive issues. For a long time, it was unclear why, but an international study has found a possible culprit. Study researchers believe they have found that the liver of a person with Type 1 may produce an excessive amount of a protein that can hamper digestion, according to a Science Daily report.

By comparing the intestinal tissue of people with and without diabetes, researchers realized that the cells lining the intestinal tract of people with diabetes were damaged by a substance called insulin-like growth factor binding protein 3 (IGFBP3). Excess IGFBP3 can cause gastrointestinal issues like irritable bowel syndrome, delayed bowel movements, bloating, and lack of bowel control; collectively, these problems are known as diabetic enteropathy. IGFBP3 cells attach themselves to colonic stem cells, which are coincidentally responsible for repairing wounds in the intestinal lining. As these stem cells are damaged, they lose the ability to make necessary repairs, thus creating a deteriorating digestive tract over time.

Once researchers understood the cause of diabetic enteropathy, they were able to reverse colon damage in mice with diabetes by using a drug to block the circulation of IGFBP3 cells. The researchers, who didn’t name the drug used to reverse the colon damage, believe this treatment could be cultivated to treat previously untreatable digestive problems in humans.

Of course, as people with diabetes well know, a mouse “cure” doesn’t always translate into a new treatment for humans. Still, a better understanding of the culprit behind intestinal problems in people with diabetes will likely improve treatment options in the future.

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8 Replies

  • Activity2004

    Not only type 1 but type two also have gi problems.

    1) edema of the intestinal wall hampers the intestinal motility.

    2) recurrent gi infection.

    3) nerve problems.

    A few that i could recollect. I always look for simple explanation. There are always dogs on the street and not lions.

  • suramo,

    Thanks for the information! I don't know why the article didn't compare the two types.

  • Activity2004

    They were busy finding a fantastic substance insulin-like growth factor binding protein 3 (IGFBP3) 😁😁😁😁

  • What's IGFBF3, suramo?

  • Activity2004


    You have taught me that word. See your post above. Also see in my reply before that word. 😁😁😁😝😝😝😝

  • Activity2004

    Also we take less carbs. So less fibres. We tend to be constipated.

  • The constipation issue does tend to be more when fiber is included!

  • Activity2004

    "The national fiber recommendations are 30 to 38 grams a day for men and 25 grams a day for women between 18 and 50 years old, and 21 grams a day if a woman is 51 and older. Another general guideline is to get 14 grams of fiber for every 1,000 calories in your diet."

    "High fiber foods such as fruits, vegetables, whole grains, beans, and nuts are an essential part of a healthy diet. But, if your fiber intake exceeds your daily recommendation or if you suddenly start eating too much fiber, it can result in abdominal pain, bloating, diarrhea, or even constipation."

    Usually with high fiber intake flatulence is the problem and diarrhea more than constipation. Also fibres are a source of RS - resistant starch.

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