Microorganisms, higher plants, and animals produce a large number of different protein inhibitors of a-amylases in order to regulate the activity of these enzymes. These inhibitors can be grouped into six classes based on their tertiary structures: lectin-like, knottin-like, cereal-type, Kunitz-like, γ-purothionin-like and thaumatin-like inhibitors. Some of these inhibitors act by directly blocking the active centre of the enzyme at various local sites.
In animals, a-amylase inhibitors reduce the glucose peaks that can occur after a meal, slowing the speed with which a-amylase can convert starch to simple sugars until the body can deal with it. This is of particular importance in people with diabetes, where low insulin levels prevent extracellular glucose from being cleared quickly from the blood. Therefore, diabetics tend to have low a-amylase levels in order to keep glucose levels under control, except after taking insulin, which causes a rise in pancreatic a-amylase.
Plants also use a-amylase inhibitors as a defence strategy. These inhibitors impede the digestive action of a-amylases and proteinases in the insect gut, thereby acting as insect anti-feedants. As a result, a-amylase inhibitors have potential in various fields, including crop protection and the treatment of diabetes.
Written by
cure
Administrator
To view profiles and participate in discussions please or .
Traditionally used plants in diabetes therapy - phytotherapeutics as inhibitors of a-amylase activity....
Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycaemia. There are many and diverse therapeutic strategies in the management of Type 2 diabetes. The inhibition of a-amylase activity is only one possibility to lower postprandial blood glucose levels. In our in-vitro studies we could demonstrate that different plants, mostly traditionally used in common diabetic therapy in Africa or Europe, are able to inhibit a-amylase, which is responsible for the breakdown of oligosaccharides into monosaccharides which are absorbed. An inhibition of a-amylase activity of 90% was seen with the extract of the leaves of Tamarindus indica. To quantify inhibtion rates, acarbose was used (IC50: 23.2 µM). Highest inhibition level of acarbose in our testmodel was about 85%. Additionally tests with pure polyphenolic compounds might explain the biological activity of the selected plants.
arey 9-10 chapati khana don't think in dreams even. Whatever medicines available to control sugar why should we eat sugar ? When we can control with diet only. Our basic defect is not going to change. Only medicines to be thought of are the ones which can improve bcf and lower ir.
Voglibose is a horrible drug? It induces vomiting after eating when taken half an hour before meal and it is totally intolerable...what are your experiences of this drug?
I know this low carb or no carbs diet hype especially for diabetics is the talk of the town nowadays but somehow I feel carbs are the only form of macronutrients for instant energy...and with carbs, digestive system remains normal as opposite to high fat or high protein or high fibre diet....I believe atleast 50% of yr daily calorie intake should be from carbs and however even high protein sources likes beans and legumes along with dairy also have carbs in it apart from vegetables and fruits...so no human can survive basically without carbs....problem is with simple sugars which increase insulin level drastically with fall down later but complex carbohydrates are good....they release glucose slowly and have enough fibre in it...
It's good if it works for you but may not work for all. I believe more in low glycemic index and glycemic load foods if you know what is GI and GL. And by the way, it's a lot of hassle to count carbs for each meal limited to only 20%....a day...are you sure u can count accurately with complex structure of all food items and even the serving portions?
I can understand that because when you reduce your carbs intake drastically, body tries to get energy from breaking down fats which is good...but people have to deal with carbohydrate cravings also...I personally like protein and fat but as far as satisfaction and digestive system is concerned, carbs is a major source of energy and without it, it would be difficult for even diabetics to survive though they have problem with their carbohydrate metabolism. No doubt protein and fat has a longer satiety period so you tend to eat less also but high protein diet may give rise to kidney problems and high fat to lipids/cholesterol problems in some people. So, I think it's moderation in everything that works generally even for diabetics...I don't think all people can stay on very low carbs (20%) for lifetime...
Metformin is safest of all drugs but it reduces absorption of Vit. B12 drastically from foods...you have to take vit b12 supplement atleast 300 mcg daily if u r taking metformin...and it has many other side effects too which is nausea and vomitting, reduced appetite...which is as such beneficial if you are overweight...but u can't enjoy food!
As Anup always says...for him...low carbs is the only drug for diabetes! There is no need for any other drug then....so no rotis....no spike...no drug...
Please wait for some time to see my results if diet alone controls my fbs or not. I have come to 130 range from 180 range by planning diet only with of course almost the same doses of meds.
i'm taking. But once i control my bs i will drop everything one by one. Perhaps my diet will be more stricter as dr bernstein is taking. Bcf getting poorer and poorer.
ok....so what does these inflammation markers suggests? I can understand that inflammation is the basic cause of all diseases so how it can be reduced and eliminated and how to measure it?
Ashka9 I don't know.....I never had such things....but this may happen.....and fats...may give you headache.... and yes...low carb diet may make u more aggressive....
No please. Whatever you do do as per rules. Half hearted efforts can't get you result.
First find out bcf and ir. And depending on them you can select your diet. But carbs never more than 100g/day. Less is better. If you are veg or vegan you can't avoid carbs because carbs are intrinsic constituent Of veg food .
Ashka9 ,You are even if grain free then also there is no risk of becoming carb deficient as other food items also contain carb to some extent but not in bulk.
I know that...but completely grain free diet is difficult....I don't know how to go about it...and then what to eat since I am completely vegetarian...
But that needs especially....vegetables which are available seasonally in winter...like Yam (Ratadu what we say in gujarati)..sweet potatoes and papdi daana taste better in winter only and also this Undhiyu is heavy to digest....so can eat only once a while...it contain potatoes also which is a big no for diabetics...can eat in small amounts though....
In Dhokla made at home, 2/3 is rice flour....it's fermented though...so is it not high carb? And yes besan is lowest on glycemic index and have negligible effect on blood sugar...so I would like to go for it more...all preparations containing chana and chana daal and it's flour besan is best for all diabetics. Even foreigners have identified it and trying it....
I don't like sweets..I don't like Ghari and I have never eaten it in my life after tasting may be once and not liking it .I don't know how my beta cells have gone haywire... I believe certain dosha in our body causes certain diseases which are created by certain planets in horoscope which demands a separate discussion altogether and if I initiate it...all people will laugh at me!
It may aggravate the situation in overweight and obese persons but I don't think diabetes is a biproduct of weight gain....weight gain may be the side effect of diabetes
I have seen thin people having heart and cholesterol problems and also having diabetes...
My father is thin and eats carbs mainly...so diabetes is about your beta cells not working properly....reason is unknown
there are many items. All legumes sprouts vegetables dry fruits peanuts. Once in a while you can take roti made of jav + chana daal + almond flour + flax seed or a small millet loaf. Sour hung curd if doesn't raise your bs. There is endless list.
I know I have tried Jav ki roti with besan flour...my weight increased then also....but I am sure weight would decrease on completely grain free diet...I have done that before many times but once we again start eating rotis and other grains as in routine....weight increases again...
grain free for ever. This is trial and error. We are trying to know which diet is suitable to our body. Once you get the right numbers you have to stick to that diet for ever. You are not cured but you have controlled your D with that particular diet.
It's really very easy. Take coconut oil or eat coconut when you feel hungry. I have been grain free for about one and half months. I don't find any problem. I take flax seed / it's powder and isapgul for fibres. Also lots of salad and dry fruits.
Do you think i'm aggressive ? Taking low carb. Actually my dear friend aggression / anger is a sign of frustration. When there is discrepancy between what we want and what we get, we get frustated that is shown in our anger.
In animals, a-amylase inhibitors reduce the glucose peaks that can occur after a meal, slowing the speed with which a-amylase can convert starch to simple sugars until the body can deal with it. This is of particular importance in people with diabetes, where low insulin levels prevent extracellular glucose from being cleared quickly from the blood.
But in blood carbs are present as glucose. The carbs start getting digested right in our mouth - saliva having amylase. Further degradation / digestion occurs in stomach and intestines. The only form that can cross intestinal mucosa is glucose. There is no system in human intestines to absorb complex molecules.
So now only place for so called amylase inhibitors to act is git. Now what is their composition and can they withstand the wrath of high gi acids and enzymes? Certain speculations look very attractive but practically they fail.
It will happen in all kind of extreme diets you follow because all these kind of "extreme" diets work only for short time till you reach your plateau. Moderation is the key in diet....not talking about cocaine or morphine or tobacco or alcohol please!
I will see if I can try it from our Indian sources because I don't believe in taking any foreign made Apple Cider Vinegar...Is Baba ramdev jambul Vinegar helps in diabetes?
these are all speculations. Nobody knows if it really helps and how much. We have to try every mean with positive attitude. I'm not disheartening you but making you aware of facts. We are all trying. Nobody knows what will work on whom.
Sometimes we have to resort to extremes also. If you can't tolerate / digest you have to avoid it. If you are allergic to gluten you must stop taking wheat etc. We can't digest carbs so should take extremely low carb diet that too low gi low gl food. My diet at present is no grain, no roti. Carbs i'm getting from 1cup/ day ( turmeric) milk and veg, legumes and salads i'm taking. Yes. Daily i'm taking around 30 ml cow ghee and 40 ml coconad. So for me extremely low carb is must because i have greatly impaired bcf.
i weighed 73.7 on 14/7 today i weigh 71.8. 2 kg drop in one month only with lc and good fat. That to without any exercise. And frankly i don't realize that i'm losing weight.😊
Bhaiya pahele IF kar k to dekho. No food for 18 hrs and 5*2.. soch lo. You have to do without cheating. Ya can take tea/ milk / coffee with mct /vco/ co. By the way @cure have you tried bullet coffee?
I follow Sanatan Hindu Dharma...don't believe in Jain Philosophy....nothing happens after sunset or 8 pm time when you can't eat carbs or should not eat etc.....basically it is a simple mathematics of how much calories you consume Vs how many calories you burn...by internal (choice of foods which increase metabolism) or external metabolism...(by physical activity).........though it's good to give body some time to digest before you sleep...
Internet and yahoo rooms played a very important role in shaping my ideology(and career too!). And some veterans of this forum have such disdain for internet!
This is the worst thing you are doing by skipping breakfast. Breakfast is the most important meal of the day since "it breaks night long fast" and increase metabolism which is good even for diabetics...I don't how you take medicines without taking breakfast ...medicines cannot be taken without food.
what is VCO?
Anyway, I believe in fasting....IF...and also do fasting as much as I can...generally don't feel like eating late evening....eat light in dinner...
Diabetes is a metabolic disorder and I feel somehow you @anup are doing harm to your body by not eating breakfast...
medicines are better absorbed if taken empty stomach. Food not only interferes with its absorption but also certain substances in food may deactivate the medicine but if a medicine is not tolerated on empty stomach it can be taken with compatible food.
nah @anup look at yourself.... you are engineer....but taking lots of interest in Health.... and u got some insight about whole thing....this is because of your GURU.....
(By liking I mean it shows your interest in medical field)
Hmmm let me ask you...is ur birth time...early in the morning??? around sunrise??? two hrs age ya piche....
Bhaiya sahi bola. Wo kya kahete hai " sahi pakade hai "
@Anup jo ab tak doctors pe aag babula hota tha now he is going to practice medicine. What's he saying " life mein police, vakil and doctors se dur rahena achha " aisa hi kuchh. Now ???!! 🐒🐒🐒🐒🐒🐒🐒🙊🙊🙊🙊🙊🙊
chalo.... its really nice....you enjoy life...ad spread LCHF message.....its good....but yar....no much members in that new community...some problem yar.....kisiko bhi mod banayega... kaise kam hoga??
Chalo achha hua anup doctor nhi bana or he also would be worshipping ada/ ama/ aha and would not be preaching lc**. to yaar hum logon ko lc** ki raah koun dikhata??!! 🐒🐒🐒🐒🐒
hmm...I said ...we age ...and that includes me too ...obviously we are out of teenage and thats what I called as we age :)...its better to accept that we have aged ...
true ...almost all responsibilities over after 50 and one can spare time for oneself ...almost like freebirds
Once my client said "His daughter is grown up...then I said..."I am waiting for my daughter to grow this big up and become independent "...thats a bonus of growing older(not old)
Bhai tum mind nahi karoge....bhabi toh mind karegi????
are bahu ko samhalne ki jimmedari Bhabijee ki hai....
Tum toh net pe duniya kho jawoge....
LOL Just kidding....
But it is said....
राजवत्पञ्चवर्षाणि दशवर्षाणि दासवत् ।
प्राप्ते तु षोडषे वर्षे पुत्रं मित्रवदाचरेत् ॥
Treat the child like a prince till the age of five, like a servant till the age of fifteen. When the son reaches the age of sixteen, treat him like a friend.
लालयेत् पञ्च वर्षाणि दश वर्षाणि ताडयेत् / प्राप्ते तु षोडशे वर्षे पुत्रं मित्रवदाचरेत्
Indulge a child for the first five years of his life, for the next ten years deal firmly with the child. Once the child is sixteen, treat him as a friend.
Bhai....ek info.... bacche ko first baby food cereal diya jata hai.... but since there is no amylase activity in child's gut.... he can not digest carbs.....
Now my bcf only 26%. I'm not very far from t1d although that is not going to happen but it would be better to learn with less carbs.
My friend. Yesterday my lunch was bhindi, kadhi and fenugreek leaves millet roti. My 1 hr ppbs was 130. today rbs at 2.45 pm was 118. i took my lunch ?? at 10. So it seems that my body's regulatory system has set my bs at 130. let's see what next.
Dr richard must be taking insulin or there is no healthy way to clear glucose.
I'm a veg and can't be without carbs. Legumes, peanuts and salad that i'm taking contain carbs. Also 10% of dietary fats and 56% of protein gets converted to glucose. So i'm not on on zero carbs but yes my dear friend bcf is there and i must stay away from carbs. Why anup became diabetic at 48 and why i at ~40 despite reasonable dietic control and good amount of physical activity. The answer is bcf. My bcf started deteriorating early and so i have bigger loss. Anup's genes are better than mine. So late D for him and less damage to beta cells. And that's the reason why he can control his D with diet and life style changes. And i'm still struggling.
Dr bernstein has to take carbs and insulin to avoid DKA.
Yaar aap humse bade ho. Aap muje bhai bolte ho to india k bhai ki yaad aa jati hai. Lol..
1) yes. Every body has to find out his/ her threshold for carbs. That depends on bcf left.
2) adi baba. Bola na to prevent DKA. Don't call carbs useless.
T1d is an autoimmune disease in which beta cells are destroyed by our own immune system. This may be secondary to some viral infection whose antigenic structure is similar to beta cells.
Flushing out sugar in urine. To bade bhaiya hamara body wo hi to karta hai. Fine you are saying with drugs. Can a drug flush out exact amount of sugar so that hypo doesn't occur? Very dangerous and we are putting another suicidal weapon into the hands of people if that drug(s) can cause hypo.
why don't you try insulinum 30 homeopathic preparation ? It is not harmful .I had given to one patient .Going by the theory likes cure likes , insulinum cures the problem . I understand your reverence for modern medicine . But still I am giving this suggestion . Do you know in homeopathic cure in diabetes even sugar cane is used .
Now my bcf only 26%. I'm not very far from t1d although that is not going to happen but it would be better to learn living with less carbs.
My friend. Yesterday my lunch was bhindi, kadhi and fenugreek leaves millet roti. My 1 hr ppbs was 130. today rbs at 2.45 pm was 118. i took my lunch ?? at 10. So it seems that my body's regulatory system has set my bs at 130. let's see what next.
So now consider this. From 1hr to 5 hrs pp that is in 4 hrs i can clear just 12 odd mg/ml glucose from my blood. What a slow 😢😢 clearance.
Insulin is a protein hormone. It will be broken down / digested to amino acids in git.Also there is no system whereby long molecules can be absorbed by human intestines. Nasal spray can be successful but to a limited extent only because nasal mucosa is not meant for absorption.
Mayush mat ho mere bhai. There is one genuine scientific hope - stem cell therapy. Yes. It's helped in some alzheimer's cases and in some MI cases. Cells have been regenerated. Still under experimental stage for D. Can't say if regenerating beta cells would improve IR also or not. But there is a hope. If not us the next generations would benefit.
so you want to say ki ye jo emmer wheat hai woh khud ke andar carbs and its inhibitor dono ko le k baitha hai?
Bhai....I am just submitting information gathered...now you tell me....I am not medical professional...you are better judge... is it possible that emmer wheat digest differently than normal wheat???
Members may google more.....I am just trying to find out logic behind ShooterGeorge experiments.....
I think this emmer wheat has high fibre content which makes it resistant to the action of digestive enzymes and acids. So very low gi food but while using it as your food you have to count GL also. Personally i don't agree to the theory nor am i recommending its use at present.
Hypothyroidism is one of the most commonly cited medical reasons for needing to eat a
moderate carb diet. The main reason why carbs affect thyroid function so directly is because insulin is needed for the conversion of the inactive T4 hormone into the active T3 hormone, and insulin is generally quite low on very low carbohydrate diets.
I am having hypothyroidism by the way and my current TSH level is high where I already had to increase my dose of T4. So, I think very low carb may not work for me.
I can understand you are great advocate of LCHF diet, but I have one ebook which I am reading right now....a book on "the low down on low carb diet" which you may want to read. Very important indeed for all who follow low carb diet. Those who wish to read it, kindly give me yr email id so that I can attach that pdf file and send it to you. I don't know how to attach it here.
I can't paste link here because I have downloaded PDF file which I can send only as an attachment. Is there any feature here on this site to attach files in conversations we do? I do not know if there is one....
ok...but sometimes u need to know other's view points also...it enlightens you to more knowledge because one size may not fit all....LCHF is no doubt good especially for diabetics but some other prevailing conditions may not allow one to follow it as strictly as you say....since there is a range of percentage of carbs as a part of total calories which can be followed as it suits an individual depending on their genetic constitution, habits, activity level, and other health conditions as well. Read that book if u have couple of hours spare time some time to understand what other expert who has clinical experience has to say.
In medicine there are two routes. Step up and step down. I think for us step up is better. To start with low carbs and gradually increasing the amount.
Chalo toh fir Gurujee.....it seems I am on right path....
I am having 3 chapattis per day of long wheat....so total 66 gms...rest lentils ......almonds pista...coconut....putting all together must be 25/30 more gms...
I don't say you preach extremely low carb diet. I just mentioned the consequence of low carb or carb restricted diet for long term. May be working for you and others...not sure about me...will research more and try it with moderate carbs due to my thyroid issue...to start with
I can understand what you say about DKA...and agree with you but dread of crashing my liver or kidney...if on low carb diet or grain free diet or remove wheat altogether for long because wheat gives me satisfaction....I can just use portion control in the beginning...and if I say more...I have seen relatives having diabetes since many years and they generally don't have any complications with medications and eat normal diet with some control as required for a diabetic...live more than 70 or 80 years....it's a requirement to have a good control of blood sugar level to avoid complications but not at the price of other organs and our choice of foods..lifestyle etc....though a lifestyle can be changed....may take a little more if required to go to high fat diet as you say....
She had normal concentrations of plasma lactate and glycosylated hemoglobin. Screening for drugs, including ethyl alcohol and ethylene glycol, was negative. Abdominal ultrasonography showed hepatic steatosis.
hnnn...people say that...eliminate wheat ....grain free diet....gluten free diet....why on the earth, my family eating everything and nothing happened to them...diabetes does not run in my family....neither paternal or maternal....l am actually believing in "Simple living and High thinking" but would like to enjoy food also....relish the food....we are grown up eating with....adapting to complete change may not be possible or even required to get excellent control of blood sugar...I will prove that here time and again with lab reports....wait and watch!
I read somewhere even that 600 calorie diet completely reversed diabetes in some patients....not advisable though to take such a less calorie diet...but will try to control carbs with moderate approach and see what happens....
Very interesting discussion among you and Ashka9 . I was looking for her bcf and ir. Ashka seems to be anxious about going grain free and low carbs adversely affecting her health. But madam. We veg always get carbs in whatever we eat that is grain free. We get carbs in legumes, sprouts, hung curd, vegetables, dry fruits and peanuts. Madam. First know what is your bcf and ir. Count carbs or not but gradually you will learn to know approximately how much carbs you are taking.
Sorry for the interference anup. But your comments please.
that's what I am trying to tell you dear Mr. Anup! that....that....if smoking biri doesn't cause cancer to all and if a person having no bad habits in life can have a cancer....not eating wheat is not the only answer to managing diabetics to have desired blood sugar numbers! Who knows what happens when, why, how etc...
Are, I am very much here...not so long after 5 years....just for you to know my last HbA1c was 6.3 in end of July when blood test taken and would like to target 5.8 if possible in 6 months....let me see what can I do to achieve that and I will post my results here then...
I will try to follow your 100 g carbs restricted diet but problem is I do not go in much detail about carb counting....and how to do that....will go mad otherwise....will see how can I control carbs as you say....yr experienced advise is always taken into account.....zero drug diabetes management after getting desired levels of HbA1c....and maintaining that....
Ok. thanks Anupji...very much for your efforts to convince me to follow this diet. Your hard work is really appreciated. Kindly post me the link to LCHF forum you are talking about so that I can initiate on how to count carbs...etc..
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.
What Is a Normal Blood Sugar Level?
Chromium picolinate a great suppliment for diabetics
Information about the diabetes based on info i have 
