Going off Rasagiline: After taking 0.5 mg... - Cure Parkinson's

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Going off Rasagiline

faridaro profile image
6 Replies

After taking 0.5 mg Rasagiline for the past 6 months with no noticeable adverse effects, recently I started having daily mild headaches and heart palpitations, which previously were only occasionally. I'll be seen my neurologist in a couple of weeks, but meanwhile gradually started reducing Rasagiline and seem to feel better in that regard. I am prone to having excess histamine and wonder if Rasagiline inhibits histamine degrading enzymes (DAO and HNMT) which I have genetic glitches with. Just wonder if anybody else had similar issues?

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faridaro
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Juliegrace profile image
Juliegrace

Although most of the research suggests that MAO-Bs do not interact with certain foods (containing tyramine) the way MAO-As do, perhaps you are having the response that some have reported. Do an internet search and examine the foods you eat. Fermented foods and aged cheeses are some of the culprits.

faridaro profile image
faridaro in reply toJuliegrace

Good point, but I excluded fermented, processed or aged foods from my diet for the past 2 years since discovered genetic low histamine clearance.

Jamielee1 profile image
Jamielee1

How do you gradually reduce from that? Isn't that the lowest dosage? I've been on since dx 1.5 yrs ago. That's all I take. I had major stomach pains. A horrible reaction. I thought it was bc of the tyramine too. I quit taking cold turkey for a couple weeks then tried again while watching food. I never had any problems again with it. And now I eat whatever I want. I think the bad reaction was from drinking too much coffee with it. I'm fine if I stick with 2 cups daily.

Jamielee1 profile image
Jamielee1 in reply toJamielee1

Also, taking sugar out of your diet will completely help your symptoms you've mentioned

faridaro profile image
faridaro in reply toJamielee1

I cut tablet in half (.25 mg) and take every other day. And I've been avoiding tyramine rich and histamine liberating foods for the past 2 years.

Roger78 profile image
Roger78

Each time I started with a new drug (rasagiline, rotigotine and L dopa) I have had headache, nausea etc) and I noticed that it was due to big stress. My solution was to take 1/2 xanax to pass these difficult stages

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