Ivermectin, anyone using it for PD?

[Blueyedgirlky]

i have friends who are asking my husband if he has tried Ivermectin for his PD. His symptoms have escalated in last 2 years . We have used C/L for years add Rytary , Azilect, Amantidine etc now Crexont and not sure he isnt allergic! We dont qualify for Vyaleve pump because of a stupid look hole so here we are. If anyone has info , first hand knowledge it would be appreciated.

[park_bear]

I took a look and found the following:

mdpi.com/2076-3921/11/5/908

Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy

Translation: Ivermectin was toxic to human neurons in cell culture

sciencedirect.com/science/a...

Acute ivermectin toxicity on skin and brain tissue of adult albino rats

sciencedirect.com/science/a...

Therapeutical doses of ivermectin and its association with stress disrupt motor and social behaviors of juvenile rats and serotonergic and dopaminergic systems

That was as much effort as I cared to put into this investigation.

[Cycleman007 in reply to park_bear]

Well studied for its anti-cancer properties. pmc.ncbi.nlm.nih.gov/articl...

sciencedirect.com/science/a...

[RonB1 in reply to park_bear]

Translation: Ivermectin is toxic in white albino Rats.

Here is a more relevant study for us humans:

cellandbioscience.biomedcen...

"Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function"

[park_bear in reply to RonB1]

So, if one chooses to ignore the toxicity issue, this has the potential to boost dopamine, like levodopa and the other dopaminergic medications that we have.

Do you plan to try this and report back your results?

Or just encourage others to do so?

[RonB1 in reply to park_bear]

I have been taking Ivermectin daily for two months now. It seems to boost the effect of Levodopa, where I move better and have more mental clarity. However, it is difficult to measure results since I tend to have good days and bad days. It doesn't seem to reduce the tremor at all.

[JayPwP in reply to RonB1]

'dopamine terminal function' means the clearance of dopamine from the synaptic cleft after its release?

[RonB1 in reply to JayPwP]

Direct quotation "Ivermectin is increasing striatal dopamine release through enhanced cholinergic activity on dopamine terminals"

[Tend]

I recently ran across a doctor, William Makis, using ivermectin to help patients with Parkinson and Multiple Sclerosis with interesting results. You might tap him on his social media to solicit a professional opinion:

x.com/MakisMD/status/185991...

[Sapporo]

ivermectin is used on humans in Africa for decades to fight malaria. They take it twice a year. Using Ethiopia and Nigerian (combined populations similar to United States) those two countries combined had total deaths from Covid 19 of about 33,000 people vs United States of over a million- so why did the Africans live after taking ivermectin and only Americans die-ask yourself why I enjoy being lied to and you have your answer

[park_bear in reply to Sapporo]

pmc.ncbi.nlm.nih.gov/articl...

"The half-life of ivermectin in humans is 12–36 hours, while metabolites may persist for up to three days."

Right. 3 to 6 days of alleged protection out of the whole year, yeah that'll keep people from suffering from covid.

[Charaf1959]

Azilect un comprimé par jour en appui au c/Ĺ. IL n'a pas d'effet secondaire grave

[Raphaekg]

From the Univ of Virginia Poison Control Center: "Ivermectin does not readily cross the blood-brain barrier (BBB) due to the presence of P-glycoprotein drug pumps. These pumps lie on the blood side of the cells lining the BBB. Any ivermectin that crosses into the cell gets immediately pumped back out, excluding the drug from the central nervous system (CNS). Because it is not able to readily cross into the CNS, it usually does not cause adverse neurological effects. "

So, if it doesn't cross the BBB, it doesn't make sense that could provide any benefit for PD.

[Esperanto in reply to Raphaekg]

You are correct in your reasoning. However higher doses might achieve some CNS penetration, this comes with significant risks of neurological toxicity. Furthermore, ivermectin's known mechanisms of action are not directly related to the underlying pathology of PD.

alzdiscovery.org/uploads/co...

[gomelgo]

I took Ivermectin for about a week the last time I had COVID (my third!). I'm not sure what it did or didn't do. But my tremors certainly got worse from the COVID and this was just about a year ago. Nothing about it was unsafe as far as my experience goes. Drugs that are cheap, seem to tend toward controversy. This kind of thing always makes me wonder who benefits from the controversy? It was used off label for many things from what I understand, and then the COVID industrial complex (I'm officially coining that term in case no one else has yet) was threatened by it. So yeah, that was my own research, not extensive, but also not expensive either! Critical thinking is a key skill all humans need, but especially those with chronic illnesses like ours. All this is simply my opinion. My "facts"