Gut biom

[LivSimple]

I'm reading more and more about the gut and supplements that may help. I'm wondering if our blood type has anything to do with gut biom. My husband is AB, the newest bloodtype and has PD.

[Boscoejean]

"“A simple blood test would allow us to diagnose the disease earlier and start therapies sooner,” Sanders said. “Additionally, a clear-cut diagnosis would accurately identify patients who could participate in drug studies, leading to the development of better treatments and potentially even cures.”

As a biomarker for their diagnostic tool, Sanders and colleagues focused on DNA damage in the mitochondria. Mitochondria are factories within cells that convert raw energy into a form that powers cells. They contain their own DNA, which can undergo damage separately from the nuclear DNA that encodes most of an organism’s genome.

Earlier studies have associated mitochondrial DNA damage with an increased risk of Parkinson's disease, and the Duke-led team had previously reported an accumulation of mitochondrial DNA damage specifically in the brain tissue of deceased Parkinson’s patients.

Using polymerase chain reaction (PCR) technology, the Duke team developed an assay that successfully quantified higher levels of mitochondrial DNA damage in blood cells collected from patients with Parkinson’s disease compared to people without the disease.

The new test also identified high levels of the damaged DNA in the blood samples of people who harbor the genetic mutation LRRK2, which has been associated with an increased risk of the disease. The assay was able to detect Parkinson’s disease patients with and without LRRK2 mutations.

A further analysis in cells from patients with Parkinson’s disease explored whether the team’s PCR-based test could determine the impact of a therapy targeting the effects associated with LRRK2 mutation."

neurology.duke.edu/news/new...

[Boscoejean]

"While research is ongoing, there's no definitive link between blood type and the risk of developing Parkinson's disease. However, studies are exploring blood biomarkers, including changes in immune cells, that might indicate Parkinson's disease progression or help in early detection.

Here's a more detailed explanation:

Focus on Blood Biomarkers:

Researchers are investigating potential blood biomarkers to identify Parkinson's disease earlier and personalize treatments.

Immune Cell Changes:

Studies have found that changes in the abundance of blood immune cells, like neutrophils and lymphocytes, could be linked to Parkinson's disease progression.

Mitochondrial Damage:

Some research has explored the role of mitochondrial DNA damage as a potential biomarker, but the WEHI team found that the link is more strongly driven by immune responses in the blood.

No Direct Blood Type Link:

While research focuses on blood biomarkers, there's no established connection between a specific blood type (A, B, AB, or O) and the risk of developing Parkinson's disease.

Other Factors:

Parkinson's disease is believed to be caused by a combination of genetic and environmental factors, and the extent to which each factor is involved varies from person to person.

Ongoing Research:

Research continues to explore the role of blood biomarkers and other factors in Parkinson's disease, with the goal of improving diagnosis and treatment. "

[LivSimple in reply to Boscoejean]

Thank You. More ideas for me to investigate.

[Boscoejean in reply to LivSimple]

and just because there has been no research to date that there is a connection does not mean that at some point in the future some type of connection might be found and then again it might not - it reminds me of a comment made by the researcher who was giving my husband the results of his genetic testing when he participated in the PDGeneration study. She said that he has no "known" genetic cause of Parkinson's however she added that we have no way of knowing if in the future if more genetic causes may be discovered through further research

[jeeves19]

in a word ‘no’.

[LAJ12345]

More likely to be diet than blood I think

[Bhaktitoo]

there are abundant valid scientific studies backing up the use of fecal microbiota transplant also known as FMT or stool transplant. Back in the 2000s, many people who contracted C difficile infection from a hospital visit died. I know because I was who almost did.It is now recommended by the American gastronomical association the first line treatment for that and has a cure rate in the 90 percentile. gastro.org/press-releases/a...

there is a lot of research into other uses and you can find papers on PubMed

truth! Stranger than fiction sometimes

[Bhaktitoo]

doctors who identify as functional medicine practitioners focus on gut health. their many websites focus on dietary/lifestyle changes, supplements, and herbal remedies for gut health/healing the gut. I was misdiagnosed with Crohn's and then IBS. Turns out I had MCAS, which I was pretty sure of, but it took me almost 3 years to find a dr. who would read the studies and look at my chart. So I did the research and improved things myself. I then found a dr not yet fully credentialed in functional medicine who was accepting insurance andwilling to order labs for me. I saw her three or four times a year. By the time she quit accepting insurance and went into no insurance practice, Iwas back to 90% of where I was a decade ago.

I also had a lot of inflammation because I had an undiagnosed autoimmune disorder that improved once my gut did. If you do a search for gut permeability or "leaky gut syndrome" you'll finda lot of information

for me, the big game changer wasa prescription for LDN, low-dose naltrexone. There's another group on this site for folks with MCAS and a lot of information about using LDN.