A lifetime of constipation issues, 15 years of Parkinson’s meds, and now the dire need for both hips to be replaced, has slowed me to a standstill - in more ways than one.
The upside is that I have been accepted at a hospital Functional Gut Center and have been working with experts who are taking my constipation very seriously.
So I have been prescribed Prucalopride, and my initial research has found scientific reports that clearly demonstrate positive results for people with Parkinson’s.
Does anybody have experience with this medication? I can’t find any references in this search engine.
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Protective effects of prucalopride in MPTP-induced Parkinson’s disease mice: Neurochemistry, motor function and gut barrier 2021 sciencedirect.com/science/a...
Abstract
Evidence suggests constipation precedes motor dysfunction and is the most common gastrointestinal symptom in Parkinson’s disease (PD). 5-HT4 receptor (5-HT4R) agonist prucalopride has been approved to treat chronic constipation. Here, we reported intraperitoneal injection of prucalopride for 7 days increased dopamine and decreased dopamine turnover. Prucalopride administration improved motor deficits in 1-methyl-4-phenyl-1,2,3,6-tetrathydropyridine (MPTP)-induced PD mouse models. Prucalopride treatment also ameliorated intestinal barrier impairment and increased IL-6 release in PD model mice. However, prucalopride treatment exerted no impact on JAK2/STAT3 pathway, suggesting that prucalopride may stimulate IL-6 via JAK2/STAT3-independent pathway. In conclusion, prucalopride exerted beneficial effects in MPTP-induced Parkinson’s disease mice by attenuating the loss of dopamine, improving motor dysfunction and intestinal barrier.
Excellent article. It also mentions Domperidone . I can vouch for the effectiveness that, of which I am prescribed for nausea with migraine. Also interested in trying Quercetin with black pepper. Thanks for that Bolt.
Prucalopride is Motegrity in the U.S. It was a new drug and I've been on it and just got it refilled. I had to be seen by the doc who first prescribed it for me before the insurance company would refill it. So I had to drive across the state and sit in his exam for an hour before he was able to see me to ask if it was helping. I said yes it was so we were done and now I have a six-month refill. I still need fiber and occasionally Dulcolax stimulant laxative but I'm okay with that.
Everybody with Parkinson's should watch this. The constant harping on about constipation rather misses the bigger picture: the entire digestive system is compromised....and Prucalopride should be a first-line treatment for many.
I have been using prucalopride (also goes under the name Motegrity), for 4 years. My PD started with gastroparesis, a slowing down of digestion and chronic constipation. The drug worked great at first then my body got used to it so while it continues to work it’s not as good as the first month or so. But it definitely works. Good luck.
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