Cure Parkinson’s and Van Andel Institute announce funding for a phase 1 clinical trial of low-dose lithium in Parkinson’s disease

[Bolt_Upright]

Cure Parkinson’s and Van Andel Institute announce funding for a phase 1 clinical trial of low-dose lithium in Parkinson’s disease - vai.org/article/cure-parkin...

"Why study lithium in Parkinson’s?

Early preclinical data suggests that lithium at very low doses may be protective against the dopamine nerve cell (neuron) loss seen in Parkinson’s. In 2019, Guttuso conducted a small pilot study to test this potential link in people with Parkinson’s. The results suggested that lithium had a positive effect on trial participants. As such, in 2022, low-dose lithium was prioritized by the International Linked Clinical Trials (iLCT) program — a drug development initiative set up in partnership between Cure Parkinson’s and VAI to support the clinical evaluation of drugs with the potential to slow, stop or reverse Parkinson’s progression."

[Bolt_Upright]

Seems to be a good podcast that explains some details: The Promise of Lithium as a Parkinson’s Disease Modifying Treatment youtu.be/1uOPS-1jOXU?si=oux...(Not working as expected?)

[Boscoejean]

I am wondering if this might be the clinical trial being mentioned and being done in NY state clinicaltrials.gov/study/NC...

[Despe in reply to Boscoejean]

Many HU PD members have been on LO. I believe Dr. Mischley recommends it.

[gomelgo]

I just restarted my lithium orotate. So this is affirming news. Thank you for posting!.

[popo1 in reply to gomelgo]

me too. what dose are you using? me, 25mcg OD.

[JayPwP in reply to gomelgo]

How much are you taking?

[Bolt_Upright in reply to JayPwP]

I take 30 mg every morning. I figure the low dose, 15 mg, did not move the biomarkers, and the medium dose, 45 mg, did move the biomarkers, so I decided to go for the middle. I may increase this eventually.

[gomelgo in reply to JayPwP]

5mg .. I guess I should be increasing it based on Bolt's response here.

[Bolt_Upright in reply to gomelgo]

Well I did graduate in the top two thirds of my high school class.

[gomelgo in reply to Bolt_Upright]

So did you gradually increase, or just start on the 30 right off the bat?

[Bolt_Upright in reply to gomelgo]

I think I started at 15 and then moved up over about 6 months as what I read indicated I should increase. I settled on 30.

[JayPwP in reply to Bolt_Upright]

😆😆😆 range is 34 to 100 %

[JayPwP in reply to gomelgo]

Don't rush

[Zella23]

Thanks for your post Bolt, very informative. Lithium orotate is in my husbands stack of supplements, so hoping it helps. He’s been taking it for quite a while now. It was mentioned on here before, and also on a post yesterday. it. It was also mentioned by Laura Mischley in her presentation, on No Silver Bullet, recently.

healthunlocked.com/cure-par...

[JayPwP in reply to Zella23]

How much is he taking?

[Zella23 in reply to JayPwP]

10 mgs per day.

[alexask]

Lithium may also prevent dementia according to this study:

pmc.ncbi.nlm.nih.gov/articl...

We observed an association between lithium use and a decreased risk of developing dementia

I have listed this (along with other potentially beneficial supplements) here

supphealthratings.com/memory

as well as other supplements for PD here:

supphealthratings.com/pd

Note anyone leaving a rating on that site before end of February 2025 will be entered into a draw to win $100 US.

[ktbooks77]

Dr. Laurie Mischley wrote a thesis on Lithium, Deficiencies in Parkinson’s Disease. Check it out here: digital.lib.washington.edu/...