Researchers add to existing evidence that vitamin B3 may help slow down the progression of Parkinson'

[CuriousMe12]

parkinsons.org.uk/news/more...

A new phase 1 clinical trial, the NR-SAFE study, has published promising signs that taking a high dose of vitamin B3 is safe, and can reduce some symptoms for people with Parkinson’s.

[Bolt_Upright]

"20 people with Parkinson’s took part in the study. 10 received 3000 mg of nicotinamide riboside everyday for 4 weeks. This was triple the dose of the previous study. The other 10 received dummy pills, called a placebo. This study was double-blind, which means that neither the participants nor the researchers knew who was taking the supplement containing nicotinamide riboside.

In line with previous research, the results showed that those who had taken a high dose of nicotinamide riboside had much more NAD, used to produce energy, when compared to the group who took the placebo.

The results also showed that taking the vitamin could improve movement symptoms of Parkinson’s. This improvement was more obvious in those who took 3000 mg of nicotinamide riboside a day, compared to the previous study where participants took 1000 mg per day."

Please do your own research. I take 1000 mg of Nicotinic Acid twice a day. This is probably too much, so again, please do your own research.

[Gcf51]

Patent Invalid: This should bring price of NR down

knobbe.com/blog/federal-cir...

[PDTom]

I have Tru Niagen at home and have been taking it for a long time, but only 600mg. I'm going to increase it to 3,000mg (that's about 300 tablets a month, costs about 350 euros) over the next few days... Let's see if anything happens...

parkinsonclub.de/en/nutriti...

[CuriousMe12 in reply to PDTom]

Keep us updated tom

[JCRO in reply to PDTom]

Keep us posted. On 900mg but willing to up that if it helps you.

[CuriousMe12 in reply to PDTom]

Do you know why a B3 Amazon search shows such a wide price difference? There's one ar £124.Is there something else on the label to check (apart from the usual suggestion of country of manufacture)?

B3 amazon search

[LAJ12345 in reply to CuriousMe12]

The one on the right is the riboside which is the same as the one in the study. The other is just niacin so isn’t the riboside. (The riboside has a ribose sugar on the molecule).,

The riboside is very expensive and b3 is cheap.

[CuriousMe12 in reply to LAJ12345]

It's annoying that the headlines are misleading by talking generally of B3.Also, it begs the questions of: 1) How much of the B3 or of the Riboside is it thats benefiting.

2) why didn't the study kill 2 birds with 1 stone and include a dozen more participants taking plain B3 under the same process

[LAJ12345 in reply to CuriousMe12]

I suspect there may be other studies with b3? It’s the riboside that is reasonably new. Hubby tried it a few years ago for about 6 months at the 300mg per day but that made no difference. It cost to much to go higher

[CRMACK1948 in reply to CuriousMe12]

Possibly it depends on how much fillers are used,where the vitamin is sourced( lab made or natural) and where they are made.I bought a fairly expensive B6 for my PWP,and then discovered it was lab made and completely useless for PD sufferers.Many large companies buy from one overseas source.Its interesting to note that exactly the same amount of each filler,and the same combination is noted on 5 or 6 of the bigger supplement companies in the UK.

[CuriousMe12 in reply to CRMACK1948]

Yes, just different branding. I hear the same molecule argument about lab made CBD and that made from leaf.

[realk]

nice, but what if you are already using High dose B1?Can these influence each other?What is the ideal rate? What is the ideal combination of all B vits as we know most Bs are beneficial for Parkinson's when studies performed separately ... And how it goes hand to hand with detoxification and methylation cycles..??

[LAJ12345]

Note the study is using the riboside, not normal niacin. The riboside is quite expensive in comparison to plain b3.

[fido2]

I take 900 mg (True Niagen) and improved when I increased from 300 mg. I was really surprised, so should not be placebo.

[JCRO in reply to fido2]

Same as me.

[Hope-full1970]

Do you take b3 yourself? If so how much and have you seen a difference?

[CuriousMe12 in reply to Hope-full1970]

Not to date. But the other day rushed to buy plain b3. It's pointed out above that I shudve possibly gotten the expensive stuff. DOH!

[Gcf51]

So TRU NIAGEN patent has been ruled invalid (link in my post above). How do you tell if any of the cheaper NRs are the real thing?

[jeeves19]

I’m curious how you all afford such a product at 900mg. It ranges between 60-130£ in Amazon U.K..,That must be about 100/180$ in the US.

[CaseyInsights in reply to jeeves19]

Not all of us are poor 😳🥲😳

[jeeves19 in reply to CaseyInsights]

Evidently! You don’t have to be poor to not be able to be afford such supplements though! Just have some kids.

[Router_ in reply to jeeves19]

Will get cheaper soon, the new 1000mg dose was launched in the US and it seems the pricing is only a small premium to the 300mg. I guess people will then switch to 3000mg per day

[jeeves19]

👍😊

[MBAnderson]

consumerlab.com/reviews/rev...

[MBAnderson in reply to MBAnderson]

pubmed.ncbi.nlm.nih.gov/297...