Stem Cells Trials

I want to make a list here. Please reply with links

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BlueRock Therapeutics (Phase 1)

* BlueRock Therapeutics: Phase 1 Study To Assess the Safety and Tolerability of Human Embryonic Stem Cell-Derived Midbrain Dopamine Neuron Cell Therapy (MSK-DA01) For Advanced Parkinson's Disease (2021)

clinicaltrials.gov/ct2/show...

bluerocktx.com/bluerock-the...

Subjects will undergo surgical transplantation of the dopamine-producing cells under general anesthesia into a part of the brain called the putamen. Subjects then take medicines to partially suppress their immune system (aimed to prevent the body from rejecting the cells) for 1 year. Safety, tolerability, evidence of cell survival (using MRI and PET scans of the brain), and effect on Parkinson's disease symptoms are assessed for 2 years post-transplant.

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IMAC Holdings, Inc.

* Evaluate Umbilical Cord-derived Allogeneic Mesenchymal Stem Cells for the Treatment of Bradykinesia (2020)

clinicaltrials.gov/ct2/show...

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The University of Texas Health Science Center, Houston (Phase IIa)

* Phase IIa Randomized Placebo Controlled Trial: Mesenchymal Stem Cells as a Disease-modifying Therapy for iPD (2020)

clinicaltrials.gov/ct2/show...

* Allogeneic Bone Marrow-Derived Mesenchymal Stem Cell Therapy for Idiopathic Parkinson's Disease (2015) Phase 1, Completed

clinicaltrials.gov/ct2/show...

* Phase IIa Randomized Placebo Controlled Trial: Mesenchymal Stem Cells as a Disease-modifying Therapy for iPD, 2020, Active

clinicaltrials.gov/ct2/show...

youtube.com/watch?v=9qq0WRd...(Not working as expected?)

youtube.com/watch?v=MQZlVej...(Not working as expected?)

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* Aspen Neuroscience Launches First Patient Screening Study for Planned Clinical Trial of Personalized Cell Replacement in Parkinson’s Disease (2022)

aspenneuroscience.com/pr-ap...

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Hebei Newtherapy BIo-Pharma technology Co., Ltd.

* Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Parkinson's Disease (2018)

clinicaltrials.gov/ct2/show...

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* The Chinese stem cell trial

scienceofparkinsons.com/201...

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Hope Biosciences, 2021, phase 2

* Clinical Trial for Parkinson's Disease Using Allogeneic HB-adMSCs (Early and Moderate) (PD) (HBPD04) (2021)

clinicaltrials.gov/ct2/show...

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Hope Biosciences, 2021, active, phase 2

* Randomized, Double-Blind Clinical Trial for Parkinson's Disease (Early and Moderate) (PD) (2021)

clinicaltrials.gov/ct2/show...

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Sweden: THE STEM-PD CLINICAL TRIAL, Phase I/IIa

stem-pd.org/

October 2022, STEM-PD, has been given regulatory approval for a Phase I/IIa clinical trial.

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Mass General mcleanhospital.org/news/new...

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Doc George Lopez stem cell trial funder and BRAVE recipient. youtu.be/cN2ZgSStm7I(Not working as expected?)

I documentary about him is available

[Bolt_Upright in reply to Hidden]

Wow!

[Hidden in reply to Hidden]

Thanks for the update.

I was asking about this here healthunlocked.com/cure-par...

[Hidden in reply to Hidden]

I had a great zoom call with the Mass General doctors doing this. I can check in with them again. Actually, maybe Michel from No Silver Bullet would want to interview them. That would be great!

[Hidden in reply to Hidden]

Michel0220

[Canddy in reply to Hidden]

This actually brought tears to my eyes - thank you cc!

[sdiers]

clinicaltrials.gov/ct2/show...

Clinical trial sponsored by Hope Biosciences Stem Cell Research Foundation to study the response of Parkinson's disease to 6 infusions of allogeneic HBadMSCs, Hope Biosciences product of 200 million allogeneic mesenchymal stem cells vs placebo. Actively enrolling

[sdiers]

clinicaltrials.gov/ct2/show...

Hope Biosciences Stem Cell Research Foundation's intermediate size expanded access to study the response off 10 participants ages 76 to 95 who have Parkinson's disease to 6 infusions of HBadMSCs, Hope Biosciences product of 200 million autologous mesenchymal stem cells. Actively enrolling

[Hidden in reply to sdiers]

added to the list, thanks.

[jeffreyn in reply to sdiers]

Link is incorrect. Here is the correct link.

clinicaltrials.gov/ct2/show...

[sdiers]

clinicaltrials.gov/ct2/show...

Another study being sponsored by Hope Biosciences Stem Cell Research Foundation to treat early to moderate Parkinson's disease with 6 infusions of HBadMSCs, Hope Biosciences' product of 200 million autologous mesenchymal stem cells vs placebo. Anticipating interim data analysis in the very near future

[jeffreyn in reply to sdiers]

"Anticipating interim data analysis in the very near future"

Hi sdiers,

Is there any information from the interim data analysis that you can share with us?

Thanks,

Jeff

[Hidden]

Does anyone have any info on this study?

parkinsonsnewstoday.com/202...

[jeffreyn in reply to Hidden]

Are you asking about MJFF's PPMI study, or Fujifilm's pre-clinical work producing stem-cell-derived dopaminergic neurons?

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youtube.com/watch?v=MQZlVej...(Not working as expected?)

[RooJr]

Excellent list!! Appreciate your continued work on this!

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BlueRock completes enrolment in phase 1 trial in patients with Parkinson’s disease

pharmabiz.com/ArticleDetail...

The primary objective of the Ph1 trial is to assess the safety and tolerability of BRT-DA01 transplantation at one-year post-transplant. The secondary objectives of the trial are to assess the evidence of transplanted cell survival and motor effects at one- and two-years post-transplant, to evaluate continued safety and tolerability at two years, and to assess feasibility of transplantation.

As a next step, BlueRock Therapeutics plans to initiate a global non-interventional study in the second half of 2022.

[Mlvh]

Good recent discussion of this subject from World Parkinson’s Coalition.youtu.be/ZXaxpVDqaYE(Not working as expected?)

[Zardoz in reply to Mlvh]

Thank you, that video answered so many questions about stem cell therapy.

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youtube.com/watch?v=4HDemOR...(Not working as expected?)

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healthunlocked.com/cure-par...

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cedars-sinai.org/newsroom/s...

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Swedish Medical Products Agency grants approval for clinical study of new stem cell based Parkinson’s Disease treatment

lunduniversity.lu.se/articl...

stem-pd.org/

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youtube.com/watch?v=YA15xO1...(Not working as expected?)

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youtu.be/12-YpTVrjw4(Not working as expected?)

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hopebio.org/Article?N=000301

HBSCRF Article

10 FEBRUARY 2023

Houston Research Organization Successfully Treats 24 Patients in FDA-Authorized Parkinson’s Study

It was all smiles at Hope Biosciences Research Foundation (HBRF) this week as the 24th and final patient arrived for their end-of-study visit, officially closing out a Food and Drug Administration (FDA)-authorized clinical trial assessing the efficacy and safety of autologous adipose-derived mesenchymal stem cells in improving activities of daily living and quality of life in subjects with Parkinson’s Disease.