Anyone had experience with Glutathione? Intranasal / IV / IM?

[chenmor]

We're exploring adding Glutathione to our protocol to fight oxidative stress.

Curious what method works best based on your experience? And where did you order it from?

Thanks!

[park_bear]

I tried inhaled glutathione using a nebulizer. It did not seem to make any difference.

[chenmor in reply to park_bear]

Understood thank you!

[SuuSuu in reply to park_bear]

Having done the intranasal..I don't think the nebulizer is comparable. I think it would create a mist that you breathe and it would go to the lungs. In Mischley's study the application was done with a syringe shaped, ultra-fine mister that you put up your nostril and then push the... plunger (? I don't know what it's called!) When we described the process to a psychiatrist friend he said, "Every addict knows the quickest way to the brain is through the nose!" So, at 58 y/o I learned how to "snort" my drugs!! ;-D

[chenmor in reply to SuuSuu]

Love it! Do you have a recommendation for what you've used / a guide? We'd love to try.

Has it helped with oxidative stress and symptom management?

[JayPwP]

Do you take NAC or Melatonin? They supposedly boost cellular glutathione production and are very effective antioxidants on their own.

[chenmor in reply to JayPwP]

Haven't tried NAC. Adding Melatonin this week before bed.

[JayPwP in reply to chenmor]

Sustain for 3 months before adding anything else to know the effect.

[chenmor in reply to JayPwP]

This is definitely a tricky part — since there are at least 10 different variables at play at any given moment.

But noted and will pay attention! Thank you!

[SuuSuu]

I participated in Laurie Mischley's 2015 intranasal study. I had been taking NAC and had to stop 90 days (I think it was 90) prior to starting the research. Stopping oral NAC I noticed a significant increase in stiffness. I was in the high dose arm, (I learned later) but had an immediate pronounced improvement! (Unlike some other subjects). After the 3 month study we had 30 days with no glutathione or NAC and the stiffness gradually returned. With the study complete I resumed NAC and again received benefit.

Were the benefits equal? Maybe... close enough that when factoring in the cost/benefit ratio of the two, I've chosen to continue the oral only. Laurie insists that NAC is NOT good, but I've never noticed any ill effects. But I respect her opinion so for the last 5 years have used glutathione 500 mg orally. I use NOW brand although Laurie says any brand will do, even the cheap ones.

FYI If I miss a day or two of it, my mobility is negatively impacted. Hope this helps.

[chenmor in reply to SuuSuu]

Thank you so much!

So now you're not on NAC but on Glutathione 500mg orally (assuming pills / tablets).

Does it slow down progression by tackling oxidative stress?

[SuuSuu in reply to chenmor]

NAC is a precursor to glutathione that crosses the bbb (blood brain barrier.) Glutathione doesn't cross the bbb. Mischley just shakes her head and says people she's surveyed that are doing well, take glutathione. She hypothesizes that it provides glutathione elsewhere in the body allowing more "building blocks" (my term) to be allocated for brain needs of glutathione.

How would I know if it's helping oxidative stress? I'm a bit of an odd duck. I was diagnosed 11 years ago but have virtually no tremor. I think it's progressing slowly although I have many symptoms. So is it slow because of glutathione, or an active lifestyle, or good sleep, or 40 years vegan diet or low stress or the Lord's blessing? Probably all of them.

I do know that when I miss the glutathione I'm stiffer and slower.

Yes 500 mg glutathione capsules.

[Dianne266 in reply to SuuSuu]

Just one capsule? What time of day? With or without food and supplements?

[Missy0202 in reply to Dianne266]

I was told that it is most effective to take Glutathione in the am on an empty stomach at least 30 min before food or coffee. I take liposomal glutathione

[SuuSuu in reply to Dianne266]

Yes, like Missy above, I take one capsule with the water I drink upon rising and wait at least 30" before eating. I'm not taking the liposomal formulation.

[chenmor in reply to SuuSuu]

This is so fascinating:

- Vegan diet (no lectins, gluten, dairy)

- Active lifestyle

- Good sleep

- Low stress

- Lord's blessing (very important!)

- And Glutathione, not NAC

Noted. Thank you so much!

[JayPwP in reply to SuuSuu]

Positive testimonials like this are, in my mind, such forums are all about.

[chenmor in reply to JayPwP]

What do you mean?

[BeedieBird]

I'm using Glutathione for about 6 months now and noticed a difference within 30 days. I use a spray developed by a pharmacist that has been developing IV glutathione for years used by doctors for patients. But, he says the body can not use Glutathione orally or IV as it breaks down too quickly. Thus he developed a spray that goes through the skin. I don't have tremors, well, I have resting tremors, but I'm predominantly rigid PD. It's helped me tremendously in terms of energy and stiffness and I'm sure to help detox. Glutathione is the 2nd most abundant molecule in the body, next to water, so I've read. This is the product I use:

aurowellness.com/?campaigni...

[chenmor in reply to BeedieBird]

Thank you so much for sharing! This is so useful

[chenmor in reply to BeedieBird]

To be clear this one isn't intranasal but you're saying skin absorption is also great?

[BeedieBird in reply to chenmor]

Based on the studies conducted by the pharmacist who developed IV glutathione solutions for MDs providing it to their patients, he says, yes, glutathione via skin will not break down as it does via other routes and thus becomes more useful and less wasteful. You'll have to go to the website and read further his information and the studies that have been done.

[chenmor in reply to BeedieBird]

Yes I'm emailing with them back and forth thank you!

[BeedieBird in reply to chenmor]

that's great. They are very responsive.

[chenmor in reply to BeedieBird]

By the way - where do you spray it? Assuming we are hairy men!

[BeedieBird in reply to chenmor]

They recommend on your stomach. But yes, where there is no hair if possible. I don't have a problem with that. May have to shave a small spot just for the spray

[JayPwP in reply to chenmor]

😜😜😜

[barrie1757 in reply to chenmor]

Link?

[Astrojupiter]

I have a hereditary Parkinson that responds extremely well to lithium so I can’t say whether it helped Parkinson’s disease or not. I did take it for three months as a rectal suppository high dose. That’s supposed to be well absorbed. I took it for a demyelinating neurologic condition., chronic issues associated with that. Two things improved one was pain., and some weakness that I’ve had for a decade. The pain came back almost immediately after stopping, but the weakness in my left leg has not come back and I’ve been off many months . I took it for three months, but I got the vast majority of benefit within the first 10 days. In fact, after about two weeks, I don’t think I got any additional benefit for the 2 1/2 months after that. Regular use of course my body would stop making it and I’m not ready for a lifelong commitment to it. plus not completely convinced about the safety of high dose. Plus, of course cost issues. I just decided next time to use it for for two weeks and cycle off of it. Giving my body a chance to fully recover and start making its own again. I’ll definitely use it in the future, but I’m not at a point where I would want to take it regularly.

I also had new onset diabetes. It didn’t improve that at all.

[chenmor in reply to Astrojupiter]

Understood. Thank you for sharing.

For Diabetes did you try high dose thiamine?

[Astrojupiter]

I use a lot of thiamine. But I never pushed dose to toxicity.

[chenmor in reply to Astrojupiter]

There's no toxicity. Look into the research, the body is naturally very good at adjusting thiamine levels. Worst case is you get a little fatigue and then reduce dosage.

Didnt help diabetes?

[park_bear in reply to chenmor]

Too much thiamine does have adverse effects. Commonly reported here. In my case, it interferes with sleep.

[Astrojupiter]

I looked at the research, but when it was used as a N I think it was Vietnam. There was a lot of renal failure associated with it. I made it illegal after that I think it may have just been contamination because these IVs were being done in areas that really were not sterile. However, there is a hypothesis that extreme up and downs problems.

[chenmor in reply to Astrojupiter]

Not sure I understand. Heard of many successful case studies + research. Are you certain?

[Astrojupiter in reply to chenmor]

AI not great place to get info but confirms my memory of it It was Korea where problems were noticed and apparently very widely used That said , cochrine review did not mention anything and as far as I know kidney issues were limited to this one country, doing it in nail salons etc Who knows why they had an issue Maybe real problem only came up with very heavy community use, maybe ethnic difference, contamination of the products, unusually high doses. I never saw any hypothesis except maybe varying dose cause it

Obviously risk is very low

per grok

Yes, there have been concerns regarding the use of glutathione for skin lightening in Korea and elsewhere. According to various reports and regulatory advisories:

- **Regulatory Actions**: In Korea, glutathione has faced scrutiny, especially when used for non-medical purposes like skin whitening. The Korean FDA hasn't explicitly "outlawed" glutathione, but its use for cosmetic purposes, particularly in injectable forms, has been heavily regulated due to health risks.

- **Health Risks**: Glutathione injections for skin lightening have been associated with several side effects, including renal (kidney) issues. This is primarily because glutathione can affect kidney function when administered in high doses or inappropriately. The FDA in the Philippines, for instance, issued warnings about the use of glutathione for this purpose, highlighting potential toxic effects on the liver, kidneys, and nervous system.

- **Usage and Safety**: The practice of using glutathione for skin lightening is not just prevalent in Korea but in other countries as well, often driven by beauty standards favoring lighter skin. However, the safety of this practice, especially through IV administration, has been questioned due to insufficient evidence supporting its efficacy and significant risks of adverse effects.

- **Public Health Advisories**: Due to these health risks, health authorities in various countries have advised against the use of glutathione for cosmetic purposes without proper medical supervision. This includes warnings from the U.S. FDA, which has not approved glutathione injections for skin lightening and has noted potential safety risks.

The conversation around glutathione, especially for cosmetic use, highlights the need for caution. Users are encouraged to seek medical advice before using such treatments, understanding that while glutathione has health benefits when used appropriately (e.g., for liver protection), its cosmetic use can lead to serious health issues if not managed correctly.