Dr David Perlmutter's IV Glutathione treatment to enable PwP to walk.

[M1tz1]

A brief YouTube presentation shows the neurologist Dr David Perlmutter in his successful use of IV Glutathione to enable a Vietnam war vet to walk and to talk. The video was made in 2010 and, given the favourable outcome, one wonders why more use of this procedure is not made. I suspect that cost is the reason because it has to be repeated regularly.

[Greenday]

A small scale human study with IV glutathione produced inconclusive results. IV administration is considered by many as impractical for long term treatment. Instead the trend is towards liposomal glutathione ncbi.nlm.nih.gov/pubmed/288... or other more biovailable methods which may readily penetrate the brain barrier, such as nano-liposomal ncbi.nlm.nih.gov/pubmed/262... or intranasal administration ncbi.nlm.nih.gov/pubmed/284... . Possibly those that will benefit most are the ones with low glutathione levels, which is very common amongst PD patients ncbi.nlm.nih.gov/pmc/articl... .

* Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease.

Hauser RA1, Lyons KE, McClain T, Carter S, Perlmutter D.

ncbi.nlm.nih.gov/pubmed/192...

"The objective of this study was to evaluate the safety, tolerability, and preliminary efficacy of intravenous glutathione in Parkinson's disease (PD) patients. This was a randomized, placebo-controlled, double-blind, pilot trial in subjects with PD whose motor symptoms were not adequately controlled with their current medication regimen.

Subjects were randomly assigned to receive intravenous glutathione 1,400 mg or placebo administered three times a week for 4 weeks. Twenty-one subjects were randomly assigned, 11 to glutathione and 10 to placebo. One subject who was assigned to glutathione withdrew from the study for personal reasons prior to undergoing any postrandomization efficacy assessments. Glutathione was well tolerated and there were no withdrawals because of adverse events in either group.

Reported adverse events were similar in the two groups. There were no significant differences in changes in Unified Parkinson's Disease Rating Scale (UPDRS) scores.

Over the 4 weeks of study medication administration, UPDRS ADL + motor scores improved by a mean of 2.8 units more in the glutathione group (P = 0.32), and over the subsequent 8 weeks worsened by a mean of 3.5 units more in the glutathione group (P = 0.54). Glutathione was well tolerated and no safety concerns were identified.

Preliminary efficacy data suggest the possibility of a mild symptomatic effect, but this remains to be evaluated in a larger study."

The following is a video taken by D. Perlmutter for one of his patients:

youtu.be/KWuOezgVHdI(Not working as expected?)

[M1tz1 in reply to Greenday]

Thank you Greenday, for going to all this trouble. Bless you.

[Cbgs in reply to Greenday]

And this is exactky why I'm off all of my supplements ....

[Greenday]

Noticeable benefits after 2 months of oral administration with the following formulations.

- LivOn Altrient/LypriCel Liposomal Lipo-Spheric Glutathione 450-750mg / day

- PharmaNAC effervescent 900mg / day

- B-Complex (Liposomal)

Changed to every other day NAC after 2 months. I have to observe though whether any benefits are sustainable over time. Occasionally replace LipoSpheric with a cheaper liposomal formulation which comes in bottle instead of satchets due to the high cost. Have been taking NAC and glutathione at least 8 hours apart.

Before glutathione therapy, blood exams showed very low levels of free glutathione:

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Free Glutahione (GHS): 500 umol/l, (Range: 500-1500)

Oxydized Glutathione (GSSG): 108 umol/l

Ratio GSH/GSSG: 5, (Normal: 10-15)

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I received Glutathione in ice packs. Glutathione is very susceptible to heat and should be handled in controlled temperatures, otherwise it may get easily degraded and oxidized.

[Kia17 in reply to Greenday]

Greenday

Would you tell us when did you start and what was the benefits?

Would you recommend the liposomal Glutathione from this company?

evolutionorganics.co.uk/alt...

[Greenday in reply to Kia17]

Approx. 2 months, less rigidity, less muscle pain, better energy levels, less fatigue and benefits persistent for at least 10 days so far . However there was a short period where the symptoms considerably exacerbated and the energy levels dropped, after this short period the symptoms considerably improved. Noticeable Improvements experienced after 2 months.

I cannot tell whether the improvement is to be attributed to the combination of glutathione with 900mg effervescent NAC (different timing though). I also changed to liposomal B-complex which more bioavailable.

Altrient & LypriCel are identical gluathione formulations from the same company LivOn, they both include the same lypospheric setria glutathione. This is one of the highest quality and most expensive glutathione that can be found in the market. The glutathione comes in individual single-to-use satchets to avoid degradation once opening. If you buy request to send with gel ice packs and with the latest expiration date possible. The taste is horrible as it should be, but if you drink with juice is tolerable enough. Once arrive refrigerate, but do not freeze. The manufacturer suggests 1-2 satchets a day.

[Kia17 in reply to Greenday]

Many thanks.

[LindaP50 in reply to Kia17]

My wife did research and found information supporting the benefits of IV Glutathione. Talked to my neurologist 2 weeks ago. They are still searching to see where I can get an IV Glutathione - their office cannot handle, local hospitals cannot handle. I contacted an IV infusion therapy firm which is on my insurance plan but they don't even offer Glutathione. Drs. office is still investigating.

Why is everything so difficult! I'm considering trying the nano-liposomal. Thoughts?

[LindaP50 in reply to LindaP50]

We (my husband has PD) are also considering the nano-liposomal - for a few reasons. 1) seeing an integrative doctor 2) costs $75 for each IV push of glut 3) two hour travel time roundtrip 4) long-term effects of shots in arms 5) need to have a dr visit every 3 months to continue IV shots and the dr visits costs $225 - all of this is out-of-pocket.

Yes, sometimes it seems everything is "so difficult" just as you state!! But we all shrug it off and move forward to find a solution to get better or at least slow down PD!

[ElliotGreen in reply to Greenday]

Hi. Thanks for this information. Any updates? Did you continue this regimen?

[M1tz1]

Where I live in South Africa, those facilities are not generally available. We're behind the rest of the Western world as a rule, but we mustn't forget our pride in Dr Christiaan Barnard who performed the world's first heart transplant many years ago!! That's not to say that medical practice here is primitive or ill-informed but the country doesn't have the economic resources now for significant research.

Greenday, I haven't been diagnosed with PD. My GP sent me to a neurologist some years ago who told me I have Intentional Tremor. I also wake myself up shaking at night, which is why I am interested in developments. I was my husband's caregiver before and during his late-diagnosed PD. He died earlier this year at age 80. I've had tremendous support from the members here both on my late-husband 's behalf and my own. You're a wonderful group of people.

[Greenday in reply to M1tz1]

I'm sorry about your husband. I understand the strength and courage it needs to become a long-term caregiver of your love one.

While I cannot give you any specific advice about you tremors, what I can tell you is that involving in daily activities, social groups, charities, exercising outdoors, balance/movement exercises (tai-chi, qi-gong) , healthy nutrition and sleep habbits, may help reduce your stress levels, uplift your mood and possibly control your tremors. Also, I suggest you having thorough blood tests for vitamins (D, B12, Folate, B6), electrolytes, minerals, thyroid, hormones, enzymes etc. as imbalances may exacerbate health conditions.

Some preclinical studies and individual patients report reduced tremors with CBD oil alone ncbi.nlm.nih.gov/pmc/articl..., there are more clinical studies under way that may crarify its pharmacological effect in different movement disorders. LivOn Liposomal Gluathione is available in SA via local distributors: ii-health.co.za/ & thenutrientwell.co.za .

[M1tz1 in reply to Greenday]

You've given me excellent advice here, Greenday. Along with many in South Africa, my health insurance is private and pricey and I doubt whether they would assist with CBD oil, which has only just been approved here for medicinal purposes. I watched an online series about it and I know that it is remarkably helpful because of the human endocannabinoid system which has receptors for cannabinoids! I am exercising daily, so I am on the right track, Greenday. You're very kind. I'll read your message again carefully and do what I can.

[Beckey]

Well, HERE'S a stupid question: What is liposomal?

[M1tz1 in reply to Beckey]

Hi Beckey, I'm no scientist. This is a reference from Wikipedia:

en.m.wikipedia.org/wiki/Lip...

I gather that in liposome form, nutrients are better absorbed and, possibly in the case of PD, can cross the blood-brain barrier. I'll leave it to our better informed members to explain.