P.E.A.

[docjleonard55]

I have developed severe arthritis in both shoulders. Needless to say it severely impacts my ability to exercise, which is so important with PD. It is not great to take too much ibuprofen which is what I have been doing. My body is also getting used to the ibuprofen and it is becoming less effective. I came across a supplement called PEA (palmitoylthanolamide) which is supposed to be good for arthritis and other inflammation. It sounds promising. Does anyone have experience with PEA? What brand, what dose and what protocol are you using? Thanks for responding.

[park_bear]

My report on this matter. I compared 8 supplements, not including PEA. According to various studies. There were 4 that had a beneficial effect:

Alleviating Arthritis - Comparing Supplements

tinyurl.com/53fvb4cz

[MarionP]

Definitely not good to get chronic with the ibuprofen and if you were developing a tolerance, meaning diminished response to the same dose, there can be some other serious side effects you will encounter and really need to avoid, you can look those up easily enough and they're pretty serious. While you are investigating your PEA at least you can look around for some other NSAID pain relievers, I would stay away from the paracetamol/acetaminophen types because of what they can do to your critical organs, but a lot of people say they are okay for pain. I found a couple of 200 mg naproxen do quite well for periodic use, and I guess nothing is great for chronic use but certainly you can do better than Ibuprofen and probably need a break from it anyway. My physician says 600mg and even 800 mg of ibuprofen is okay, unless you have been using it chronically, in which case you should drop it all together for a few months.

[MarionP]

Here is what WebMD says: webmd.com/vitamins/ai/ingre...

[Boscoejean]

"Currently, paracetamol, acetaminophen and NSAIDs are the most common treatments used to manage joint pain [157]. These drugs are associated with adverse effects including gastrointestinal bleeding, cardiovascular side effects and gut dysbiosis [158,159], and are in any case not particularly effective"

pmc.ncbi.nlm.nih.gov/articl....

"Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, naproxen, and meloxicam can help with knee cartilage pain and inflammation, but they may not have long-term benefits and could even accelerate cartilage damage: "

caringmedical.com/about/pro...

[Rufous2]

PEA is probably best known for treating neuropathic pain, but it's definitely worth trying as it does have anti-inflammatory as well as neuroprotective properties. It's not a quick fix and it can take up to 3 months to kick in. Starting dose is usually 1200 mg/day, divided into 2 or 3 doses. Once pain reduction's been achieved, it can be cut back to 600mg/day.

Several people here, including my PwRBD, take it for it's neuroprotective qualities. eurekalert.org/news-release...

[LAJ12345]

hubby uses it. Lake avenue PEA with PQQ.

megavitamins.com.au/product...

[Zella23]

My HWP and I have been taking PEA which includes luteolin for several months now. The pills are 1100 mgs PEA, 100 mgs Luteolin. We both take it in the morning, myself for arthritis in many joints and my HWP for his back pain. One soft gel per day.

No adverse effects at the moment. My joints, especially my hands are not quite so painful, and my husbands back and general discomfort, he calls it, seem to be helped. Neither of us take pain killers of any sort, they upset my stomach, and my husband says pain killers just make him sleepy and don’t do much so he rarely takes them.

It’s worth giving it ago but it’s quite expensive, I buy this make on Amazon U.K.

Container labelled with PEA

[JCRO]

The Ultra Micronised version is thought to be more effective. It’s referred to as umPEA but you probably know that. Best taken with Luteolin.

Decent overview here:

mdpi-res.com/d_attachment/b...

I take 1 x Normast 600mg per day plus 100 mg of Luteolin. Peripheral Neuropathy reduced over last 6 months to almost zero.

I have injuries in both shoulders which may be bilateral bicep tendonitis as well as hamstring problems. Cracking and snapping noises in my shoulders and plenty of discomfort with overhead activities. So that's not been great and umPEA clearly hasn't prevented it. I read in a couple of places that tendinopathy is an issue with PD (which would explain the issues that I'm having):

journaloforthopaedicscience...

(abstract only but you get the picture)

[ghoegap]

We bought Rosmolo liposomal PEA 1000 mg with luteolin micronised 120 softgels for 36.99 dollars from amazon.com ( we are in SA) . Certainly thought it helped with hwp sciatica and was talk of it being neuroprotective too.

[Possmenatt]

Ive been on PEA with Luteolin for around a year. Sever spinal arthritis. I’m sure it helps 😃. I still work in a physical manual job and I’m happy to keep it apart of my stack. I take one in the afternoon.

PEA

[Possmenatt]

I also tried these. Haven’t noticed any difference. 😃

PEA

[Ashti]

An extremely healthy solution (but hard to do for most people since it involves changing what we eat) that worked for my arthritis-like symptoms, including shoulder pain: I changed my diet drastically and now eat as close to a ‘whole-food plant’ based diet as possible - the bulk of the peer-reviewed nutrition research points in this direction. Whole intact grains, legumes, vegetables especially greens and cruciferous vegetables, fruit especially berries, nuts especially walnuts, seeds especially ground flax seed, vitamin B12, D, and algae based Omega 3 (Add all that while working towards dropping animal food, especially dairy and also dropping highly processed foods, and including oils). It reversed what my rheumatologist thought was most likely, based on blood work and symptoms, lupus. My husband with Parkinson’s is now on the same diet and no longer has trouble with his shoulders (a very common early symptom before Parkinson’s diagnosis). Increasing fibre (most easily done with whole intact grains like oats, wheat berries, barley, quinoa, and legumes like lentils and chick peas and black beans) is a recommended strategy to decrease inflammation. As an aside, this way of eating is the only diet shown to stop and in some cases reverse cardiovascular disease (our biggest killer). Canada’s food guide, which was revamped based on the peer-reviewed nutrition research with out the influence of the food industry, no longer has dairy as a food group, for instance, is worth checking out. Just thought I would throw this approach into the mix. Good luck!

[docjleonard55 in reply to Ashti]

Thanks for the input. I try to adhere with a MIND diet which is close to what you do. I do however stray from this somewhat (old habits die hard). The problem is that I have bone on bone in my shoulders that was caused at least partially by a torn labrum on my right, so the dietary changes I have made are of no help.

[Bracondale]

I have found PEA very effective for inflammatory discomfort. It's poorly absorbed so a micronised or liposomal form is better. Its' half life is short so best taken in smaller doses throughout the day (ideally with a meal). I'm using Nature's Truth 'Levagen Plus' 300mg, three times daily and may add an extra dose at bedtime. I was interested to read that it is an alternative to CBD!

[Payparky]

I was able to self-cure my arthritis by taking the following. No one is making money off this but it works so it’s basically been scrubbed from the internet.

There’s a book written about it.

The One-Minute Cure: The Secret to Healing Virtually All Diseases

Madison Cavanaugh

My own method for taking H2O2

1 . Try to take on an empty stomach and at least an hour after eating. Morning and evening if possible.

Fill a small dropper bottle with H2O2 35% food grade (you can usually ask the pharmacy for one or buy a small dropper bottle online)

This is so you can count the number of drops and so you don’t get it on your fingers. You should flush your fingers and hands after handling with water to avoid burning your skin white. It stings if you get it undiluted on your skin and if you don’t rinse it off right away but it will fade after several minutes. BE CAREFUL TO RINSE IT OFF FINGERS AND SURFACES

2. Fill an 8 to 10 oz glass full of drinking water and have it near

3. Find a small or shot glass sized container to drink from.

3. Put about 1 to 1 1/2 inches of water in the small glass (A small enough amount that you could toss it down with one or two quick swallows)

4. Add the drops of H2O2. Start with 4 the first time and add 2 more each time. Work up to 12 or more if needed to get rid of symptoms.

5. STIR VIGOROUSLY- WATER and H2O2 DO NOT MIX

6. Swallow the shot glass and before there’s time to taste it, IMMEDIATELY follow with the full glass of water drinking steadily and finishing the water so you don’t have an opportunity to taste the H2O2. You don’t have to drink it fast.

7. Dosage: I started with 4 drops morning and evening working up to 12 per dose.

8. Store bottles in freezer. Out of the reach of children. It never freezes solid.

walmart.com/ip/O-W-Company-...

You should see results beginning in about 3-5 days. Also cut back on sugars!!