An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory Events

[Bolt_Upright]

I wanted to highlight Luteolin.

We had a good thread on this 3 months ago: UM-Palmitoylethanolamide can slow down Parkinson's disease 2017 healthunlocked.com/cure-par...

And near the end of that thread people started talking about PEA with Luteolin, but I did not see the papers about Luteolin clearly called out, so here they are:

Effects of Palmitoylethanolamide on Neurodegenerative Diseases: A Review from Rodents to Humans 2022 mdpi-res.com/d_attachment/b...

"As for the human studies, two recent studies highlighted the neuroprotective PEA effect in subjects affected by PD. In particular, in an observational study, Brotini and colleagues demonstrated that oral supplementation with um-PEA slowed disease and disability score progression, significantly reducing most motor and non-motor symptoms [ 48].

Recently, Brotini has reported the potential efficacy of co-um-PEALut treatment as adjuvant therapy for patients with PD receiving carbidopa/levodopa in treating camptocormia, a postural deformity common in PD in which the spine bends forward while walking or standing. In particular, a 4-month treatment program resulted in complete resolution of the legs and trunk dyskinesia, and marked reduction in camptocormia onset [ 49 ]. Therefore, PEA, alone or co-administered and possibly integrating classical treatments, shows therapeutic potential in PD, by correcting dopaminergic deficits and motor dysfunctions, and contrasting pathogenetic aspects involved in the development of the disease."

"In particular, luteolin is able to improve the PEA morphology: while naïve PEA has a morphology featured by large flat crystals, very small quantities of luteolin stabilize the microparticles by inhibiting the PEA crystallization process [ 35 ]. The combination of PEA and luteolin makes co-um-PEALut a product able to tackle several neuroinflammatory conditions, and to have protective effects [33]."

An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory Events 2020 ncbi.nlm.nih.gov/pmc/articl...

"12. Co-Ultra PEA + Luteolin: The pharmacodynamic properties of PEA and those of luteolin appear complementary, suggesting that if administered in combination, they can fight the two main conspirators of chronic diseases: low-grade inflammation and oxidative stress. Confirming this hypothesis, many studies have shown that joint treatment using PEA plus luteolin has a superior effect compared to the molecules used alone by stimulating both hippocampal neurogenesis and dendritic spine maturation [254,255]. These studies have also shown that the pharmacological properties of PEA + luteolin (PEALut) become synergistic when PEA and luteolin were simultaneously submitted to the micronization process with a jet mill technique in a mass ratio of 10:1. This is probably due to the fact that PEA is poorly soluble in aqueous media and is difficult to formulate using traditional approaches; for this reason, the micronized and ultramicronized forms have a reduced particle size compared to the native molecule, along with a greater bioavailability."

I'm taking 600 mg of UM PEA in the morning (in my peanut butter snack) and a 600 mg Micronized PEA + Luteolin at night.

I don't think I have gotten worse in the last year (or the last 3 months of taking PEA).

[HekateMoon]

Isnt luteolin derived from Honeysuckle? Its interesting...there are tons of wild growing around the garden...i always wondered what could i use it for. Apart from the amazing scent...

[Boscoejean in reply to HekateMoon]

Japanese honeysuckle

ncbi.nlm.nih.gov/pmc/articl...

en.wikipedia.org/wiki/Lonic...

[HekateMoon in reply to Boscoejean]

Yay! They say often the remedy is at your doorstep...

[Smittybear7]

What got worse? Would you recommend trying it? Where can you get it and what dosage? Thanks for sharing

[Bolt_Upright in reply to Smittybear7]

Nothing got worse. In the arena of possibly useful supplements I put this near the top.

amazon.com/gp/product/B09B1...

amazon.com/gp/product/B07NJ...

[Smittybear7]

What medication are you on? Does this help tremors?

[Bolt_Upright in reply to Smittybear7]

I should remind everybody: I have not been diagnosed with PD. I have REM Sleep Behavior Disorder, a sore left shoulder, sore neck, sore left leg, some balance issues, frequent seborrheic dermatitis, formication, and some involuntary movements.

I don't have tremors.

I don't expect anything to quickly improve anything. The idea of the PEA, as much as I understand, is to lower inflammation. Probably some more things too. I need to make a list.

What I can say is that over the last couple months there is more of a calm about my body. Less muscle jerks. Less neck, shoulder, and leg pain. I don't know if this is from PEA, from pounding broccoli sprouts, from niacin, or from the other 14 things I do.

I take PEA mostly because of the study showing UPDRS improving over 9 months. That seems pretty cool. Even cooler if the study was for 5 years, but it was not.

Good luck. Feel welcome to ask more questions.

[reedboat2]

Bolt have you found that PEA affects your sleep cycle?

I found this introductory article online: draxe.com/nutrition/phenyle...

[Bolt_Upright in reply to reedboat2]

That article is about Phenylethylamine, which is a different PEA than Palmitoylethanolamide.

Palmitoylethanolamide (PEA) — Safe, Legal and Better Alternative to CBD medium.com/@pieterpcastelei...

[ghoegap]

Most interesting......did you ever supplement with honokiol ( recall you mentioning that not too long ago) ?

[ghoegap]

My apologies...checked back and see you are supplementing with honokiol...

[LAJ12345]

are you still taking these? How are they going?

[Bolt_Upright]

I still take 600 mg Palmitoylethanolamide with Luteolin before bed. I have not been diagnosed with PD. My REM Sleep Behavior Disorder has been acting up the last 10 days, but otherwise I have been doing really well.