shocking fraud found by leading Alzheimer's and Parkinson's neuroscientist.

[Mezmerric]

science.org/content/blog-po...

I hope there is a criminal investigation.

[Bolt_Upright]

"As the article details, this all has some direct drug discovery implications, particularly for an antibody called prasinezumab which targets alpha-synuclein. All four of the fundamental papers about prasinezumab (as cited on the web site of its developer, Prothena) are full of manipulated images, unfortunately. Prothena and Roche reported results in a Parkinson's trial with it in 2022, and the antibody was found to have no benefit at all (it's undergoing another trial now). Given the difficulty of neurodegeneration therapy, it's hard to say if that result is an honest failure of a worthwhile idea, or whether the entire effort has been built on data that simply aren't real. But we cannot rule out the second possibility, at all."

That was a distraction for us: healthunlocked.com/cure-par...

[Bolt_Upright in reply to Bolt_Upright]

"There's also a proposed Alzheimer's therapy called cerebrolysin, a peptide mixture derived from porcine brain tissue. An Austrian company (Ever) has run some small inconclusive trials on it in human patients and distributes it to Russia and other countries (it's not approved in the US or the EU). But the eight Masliah papers that make the case for its therapeutic effects are all full of doctored images, too."

We had a couple posts on this: healthunlocked.com/cure-par...

[Bolt_Upright in reply to Bolt_Upright]

"A third drug, minzasolmin, is supposed to prevent misfolding of alpha-synuclein and Masliah and co-workers published the original papers that make the case for its effects. Papers which have doctored images in them. Masliah co-founded a company (Neuropore) that has been developing the drug, and they have a partnership with Belgian drugmaker UCB. It has to be noted that this one has taken some fire already: a paper last year on its in vivo effects brought some pointed criticism that the drug's short half-life should have made it impossible for it to work under the conditions described. The authors responded that they had other evidence of the drug's mechanism, and I'm glad to hear it, because in addition to the original papers, their previous paper on the drug had images in it credited to Masliah that also seem to have been digitally modified. Minzasolmin is currently in Phase II trials."

I don't see any posts on this on HU.

[Bolt_Upright in reply to Bolt_Upright]

He is on a Mannitol paper: ncbi.nlm.nih.gov/pmc/articl...

[Bolt_Upright in reply to Bolt_Upright]

He worked on a paper identifying mitochondrial dysfunction too: The Role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer’s Disease and Parkinson’s Disease ncbi.nlm.nih.gov/pmc/articl...

[Bolt_Upright in reply to Bolt_Upright]

He has his name on a lot of papers: pubmed.ncbi.nlm.nih.gov/?te...

[crewmanwhite]

This sort of fraud has been going on for decades.

There is so much money in drug research and production - huge profits - that fraud is a habit.

This is one who got caught. There are many who get away with it.

[Mezmerric in reply to crewmanwhite]

Yes, so there needs to be an effective deterrent. Losing ones job and credibility is clearly not enough of a deterrent. Fraudulent behaviour should have criminal and financial penalties.

[crewmanwhite in reply to Mezmerric]

I agree completely

[CuriousMe12 in reply to crewmanwhite]

Prison don't apply to institutions.The Sackler family is an American family who owned the pharmaceutical company Purdue Pharma and later founded Mundipharma.[1] Purdue Pharma, and some members of the family, have faced lawsuits regarding overprescription of addictive pharmaceutical drugs, including OxyContin. Purdue Pharma has been criticized for its role in the opioid epidemic in the United States.[2][3][4] They have been described as the "most evil family in America",[5][6][7][8] and "the worst drug dealers in history".[9][10]

All of them still walk free.

en.m.wikipedia.org/wiki/Sac...

[crewmanwhite in reply to CuriousMe12]

You are quite right but maybe that is something we can pressure our legislators to change.

They are supposed to represent US.

[MBAnderson]

3,491 warning letters from the FDA to mostly Pharmaceutical companies.

fda.gov/inspections-complia...

[gomelgo]

just curious if you truly find it shocking.

[Likii in reply to gomelgo]

“Breathtaking,” says neuroscientist Christian Haass of the Ludwig Maximilian University of Munich. “People will, of course, be shocked, as I was. … I was falling from a chair, basically.”

Another lie. 🙄

science.org/content/article...