Anyone here participating in this trial?

[NewGuywithPD]

“We are pleasantly surprised to see a statistically significant drop in TDP43 levels in just 10 patients and to see a strong trend in GFAP and NfL. To our knowledge this is the first time that a drug reduces the levels of TDP43 in humans, specifically here in [Parkinson’s disease] patients,” Maria Maccecchini, PhD, Annovis’s CEO, said in a press release.

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parkinsonsnewstoday.com/new...

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[Bolt_Upright]

Very cool.

[jeffreyn]

These good results from the completed Phase 2a trial bode well for the ongoing Phase 3 trial which is due to be completed soon.

[LAJ12345]

”At normal levels, TDP-43, or TAR DNA-binding protein 43, is crucial in various cellular processes, particularly in regulating RNA, the molecule that carries genetic information, and is involved in protein synthesis in cells.

When it’s highly active, however, it builds up into toxic clumps, just as alpha-synuclein does in Parkinson’s and beta-amyloid and tau do in Alzheimer’s disease. This aggregation impairs nerve cell function, induces inflammation, and contributes to neuronal death.

TDP-43’s abnormal accumulation has been implicated in several neurodegenerative diseases, namely Parkinson’s, Alzheimer’s, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS).”

[LeharLover62]

There are a number of folks who have been in the Buntanetap trials and they have posted on earlier threads, some with quite positive response.

[Changsha]

I recently completed the Buntanetap trial. My symptoms, mainly rest tremor and some stiffness in my hand, remained the same throughout the six months. Since stopping the drug I have noticed my tremor has increased so I believe I had the actual drug and it did stop the progression. Target date for getting it on the market seems to be in two years. Hope Annovis can fast track it.

[NewGuywithPD]

wonderful for you! and us! THANK YOU for sharing!