mesenchymal stem cells

[Bluebell2022]

I thinking about having mesenchymal stem cell treatment. Does anyone have experience of this?

[park_bear]

There is no approved stem cell therapy for Parkinson's at this time. It is likely to cost a lot of money, be no help, and may even do harm.

[Boscoejean in reply to park_bear]

Is this an example:

sci.amegroups.org/article/v....

Abstract: Numerous clinical studies have shown a wide clinical potential of mesenchymal stromal cells (MSCs) application. However, recent experience has accumulated numerous reports of adverse events and side effects associated with MSCs therapy. Furthermore, the strategies and methods of MSCs therapy did not change significantly in recent decades despite the clinical impact and awareness of potential complications. An extended understanding of limitations could lead to a wider clinical implementation of safe cell therapies and avoid harmful approaches. Therefore, our objective was to summarize the possible negative effects observed during MSCs-based therapies. We were also aimed to discuss the risks caused by weaknesses in cell processing, including isolation, culturing, and storage. Cell processing and cell culture could dramatically influence cell population profile, change protein expression and cell differentiation paving the way for future negative effects. Long-term cell culture led to accumulation of chromosomal abnormalities. Overdosed antibiotics in culture media enhanced the risk of mycoplasma contamination. Clinical trials reported thromboembolism and fibrosis as the most common adverse events of MSCs therapy. Their delayed manifestation generally depends on the patient’s individual phenotype and requires specific awareness during the clinical trials with obligatory inclusion in the patient’ informed consents. Finally we prepared the safety checklist, recommended for clinical specialists before administration or planning of MSCs therapy.

[Bolt_Upright]

Where are you planning to get the treatment?

[WinnieThePoo]

google.com/search?client=fi...

59 minutes in, probably the leading expert in the field answered your question in March

[Baron1]

Good Morning,

This is a very controversial topic. Everyone has their opinion and beliefs of what, or if stem cells can help with neurological disorders.

Yes there are clinics everywhere spruiking that stem cells have helped their patients, but as I once posted here before, there are literally one million plus people just in the USA with some form of a neurological disorder. So why are there not more positive success stories in the media?

Anyway, I am inclined to be a believer that they do work, to some degree but there is a caveat as well. What type of stem cells?, and then there is also the question are they from a donor, MSC's, placenta, fetal, etc, etc, etc.

Intraveously administered or intranasal? Intranasal is showing some promise as being more beneficial by upstreaming via the olfactory bulb. The intranasal route allows for direct access to the central nervous system without crossing the blood–brain barrier, avoiding potential adverse reactions and enabling the administration of large quantities of stem cells to reach the brain.

Then there is the one question that many clinics do not explain and show the screening results, what are the stem cell sizes that they use.

If they are too big, they will end up being trapped in the filter organs, like the lungs, and spleen. When this happens research studies show that it can cause issues and subsequently the stem cells that get through to the hippocampus are limited in number, and that is why majority of people never see a benefit or only a small improvement which does not last long.

Studies have shown that those who had several intravenous doses over the course of several months had the highest percentage of change from baseline in improvements based on the studies parameters, and the improvements lasted after 24 months follow up.

I recall Jack Nicklaus has had stem cell treatment at Isar Klinikum in Munich, Germany, in 2016. So he is no fool, and he stated that it helped him for his back issues that surgery and medicine could not fix.

edition.cnn.com/2018/04/27/...

There is CellTex Houston Texas, and they administer by intravenously and intranasal. Success rate I am not sure, you may have to do some further research.

I am in Australia, so I am looking as well, but I am yet to find one place that has all boxes ticked in my opinion. They charge alot, and that is why you most first be convinced that they have a track record of success with patients and not just emptying your bank account.

Here are some links that you may want to read about Stem Cells.

statnews.com/2020/08/18/sep...

aarp.org/health/conditions-...

Best of luck and lets us know if you find anything worthy of looking into.