Supplements in food: Proanthocyanidin

[Esperanto]

Art cites Proanthocyanidin (PA) in grapefruit seed extract (GSPE) as a potential remedy in very interesting contributions about Atherosclerosis:

healthunlocked.com/cure-par...

and insulin resistance:

healthunlocked.com/cure-par...

In a recent study the data support also (again) the possible efficacy of PA in PD treatment, where they examined the neuroprotective effects of PA and the underlying molecular mechanism in rotenone model of PD.

frontiersin.org/articles/10...

So where you find those miraculous Proanthocyanidins (PA)? They are natural flavonoids widely present in many vegetables, fruits, nuts and seeds, and especially in grape seed. As a fan of good nutrition instead of pills, I had already given Art a DIY version of Grapeseed Extract:

healthunlocked.com/cure-par...

On closer examination, PA appears to occur profusely in high concentrations in the plant world. The main sources of anthocyanins in our food are fruits, not only grapes, but especially berries, such as blackcurrants, redcurrants, blackberries, blue grapes, blueberries, aronia berries, cranberry, elderberry, raspberry, oranges, figs, mangos, olives, apples (Red Delicious and Granny Smith) and pears. In addition, cereals (barley, rice, sorghum, and wheat), legumes like pinto beans, eggplant, avocado, red onions, sweet potatoes, red cabbage. Other important sources include cinnamon, cocoa bean, pine bark, Ginkgo biloba and foods such as chocolate, wine, green tea and black tea. So in a healthy (MIND) diet widely present, but if you need a pillless PA supplement you find here the ingredients to adjust your dietary preferences.

More background information about PA and also other medical applications under investigation with links:

en.wikipedia.org/wiki/Proan...

[LAJ12345]

grape seed not grapefruit seed?

[Esperanto in reply to LAJ12345]

Very confusing, but it is indeed grape seed. 🍇

[LAJ12345 in reply to Esperanto]

I think you can get grape fruit seed too but it’s for something different

[Esperanto in reply to LAJ12345]

Although there are also some uses of grapefruit seed, you may mean Wriga's research from about 4 years ago about grapefruit juice prolonging the the effect of C/L

researchgate.net/publicatio...

For about 8 months Wriga gave an update.

healthunlocked.com/cure-par...

[LAJ12345 in reply to Esperanto]

I have this stuff.

“Grapefruit Seed Extract (GSE) is a powerful broad-spectrum, citrus-based anti-microbial that can be used to extend product shelf life and protect personal skin care formulations against bacteria and fungus.”

Gse

[chartist]

Thank you for linking to what I wrote, Esperanto . For clarity, GSPE, which I was writing about, is grape seed proanthocyanidin extract which is different from grapefruit seed extract (GSE) which is known more for its polyphenol content and antimicrobial properties as opposed to GSPEs significant proanthocyanidin content which is thought to be its main component for atherosclerosis.

GSPE is also known to cross the blood brain barrier and inhibit the inflammatory mediator, IL-8 which is at significantly elevated levels in the cerebrospinal fluid of people with PD.

Art

[Esperanto in reply to chartist]

Thanks Art for the clarification. Now the question remains why should you take grapeseed proanthocyanidins extract (GSPE) if you already get about 1 gram per day of proanthocyanidins through a good diet. Eating berries and certainly the Aronia (Chokeberries) already provides a nice addition. About 500-1000 mg and dried even the tenfold! Or does GSPE contain substantial additional components that do not appear in the aforementioned fruits and vegetables?

[chartist in reply to Esperanto]

Esperanto,

GSPEs active component is proanthocyanidin and If you're getting that much proanthocyanidin from diet, you shouldn't need to add to it with GSPE.

Art

[Esperanto]

This is THE period of the grape harvest, perhaps even from our own garden. A good addition to your proanthocyanidin (PA) in your smoothie in the coming period, but interesting for the rest of the year to make jam from it. The difference with the traditional recipes of grape jam is that you should not remove the seeds and everything goes into the blender first. In addition to saving a lot of work, all nutrients are retained. A disadvantage is the amount of sugar needed in preparation. It can be significantly reduced by adding more pectin. In addition, it can be varied by combinations with other PA toppers like lemon, cassis, aronia (Chokeberries) and cinnamon.