Ozempic effects dopamine?

[pvw2]

This article implies that Ozempic increases dopamine:

msn.com/en-us/health/medica...

I'm wondering if anyone here with PD uses Ozempic and if they noticed any positive or negative effect related to PD.

[park_bear]

From the link:

"the drug helped to regulate the mice’s behavior and helped decrease their dopamine response – making them feel less of a high " [emphasis added]

[Boscoejean]

DA5-CH and Semaglutide Protect against Neurodegeneration and Reduce α-Synuclein Levels in the 6-OHDA Parkinson’s Disease Rat Model

Treatment was semaglutide or DA5-CH (25 nmol/kg, i.p.) daily for 30 days postlesion. Both drugs reduced the apomorphine-induced rotational behavior and alleviated dopamine depletion and the inflammation response in the lesioned striatum as shown in reduced IL-1β and TNF-α levels, with DA5-CH being more effective.

In addition, we found semaglutide and DA5-CH rescued neurons in the SNpc from 6-OHDA-induced toxicity and increased the level of striatal DA in PD rats, which demonstrates that both drugs can ameliorate DA depletion from 6-OHDA toxicity. The BBB-penetrating DA5-CH peptide was superior in protecting neurons and improving dopamine levels.

hindawi.com/journals/pd/202...

[Boscoejean]

In 2017 results of a large phase 2 clinical trial showed that exenatide, a drug used to treat diabetes, may slow the progression of Parkinson’s.

How does exenatide work?

Exenatide is a GLP-1 agonist. These are drugs that mimic a type of naturally occurring hormone in the gut which stimulates the release of insulin from the pancreas; but, importantly, GLP-1 agonists also have beneficial actions in the brain.

In models of Parkinson’s, exenatide can improve dopamine neuron function, reduce inflammation, improve energy production and switch on brain cell survival signals. Researchers are now trying to uncover if all of these effects also occur in humans, while simultaneously assessing its impact on the day-to-day symptoms and progression of Parkinson’s.

cureparkinsons.org.uk/exena...

[Triever7]

Yes, I’m taking Wegovy. I’m in the first month. .25 dose. This is the same drug as Ozempic. Certainly I’m less hungry and not much interested in drinking alcohol. So far not much effect on left hand tremor (which is my only symptom, dx in 2016). I’ll post if anything changes.

[pvw2 in reply to Triever7]

Hoping for the best.

[Jojaku123 in reply to Triever7]

Wow! You’ve had it for 7 years and that’s your symptom? Amazing 🤩. What are you doing to keep it at bay?

[Triever7 in reply to Jojaku123]

That’s a great question. I’ve not done anything, really. Mostly I doubt the diagnosis. I had a left shoulder injury in 2015 that became a frozen shoulder and then a tremor in my left hand, dx with PD in 2016 (age 51). I started c/l in 2019, which helped the tremor to the extent that I was able to type again. I’ve been pretty much stable since. I still can’t take more than a half dose of c/l at a time, and I take six half doses of 25/100 per day. Maybe I’ve been lucky so far. Maybe this diagnosis is a collection of symptoms too broad to mean anything in a collective sense. Maybe I don’t have it at all. I have no idea. But as I said, I’ll post about any progress with semaglutide. Thanks to everyone on this site - I’ve learned a lot.

[Jojaku123 in reply to Triever7]

that is very interesting indeed… I mean you are responding to the Levodopa to some degree so… Man… I don’t even know! I’m just glad you’re doing so well… Please keep us informed about your progress and best of luck of course!

[kaypeeoh]

"...semaglutide blunts the feeling of pleasure (through the neurotransmitter dopamine) from food, for example, making people feel fuller faster...."

So if I have PD my body isn't making enough dopamine. And this latest miracle drug sits on the receptor site and fools the body into thinking it has enough dopamine? I never realized dopamine was giving me a high. Other drugs that I used/abused in the past for a high quit working eventually. Making me try to find other sources for that high.....Ahah!

So it could cure my cherry-cheesecake-Ice-cream Jones???

[Patrickk]

Bydureon (a.k.a., Exenatide), a repurposed Type 2 Diabetes drug, is now in third-stage trials in UK for stopping Parkinson’s in its tracks — results expected 2024. Testing — mice, open label, double blind — has been going on since 2010 and it has been positive every time.

scienceofparkinsons.com/201...

According to a very sensitive test, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), 2/3 of Parkinson’s patients are supposed to be insulin resistant. IR may be treated with Bydureon (Exanatide). Just an angle that might get us one step closer to getting Bydureon.

cureparkinsons.org.uk/news/...

[Pdyogs]

yes, I was on it for a year and a half, and it absolutely made a difference. My insurance stopped covering the Ozempic early this year, and my tremor has gotten much worse, as has my rigidity Ozempic also reduced any urges to binge, whether the food, alcohol, TV, shopping…which was so refreshing. I attributed that to some sort of dopamine response as well.

[gomelgo in reply to Pdyogs]

How much of it were you taking, and are you still taking it now? I saw a functional health person talk about "microdosing" it. Seemed very hopeful.

[Nicopwp]

Ozempic is a drug used to treat type 2 diabetes mellitus. It is not approved for use in Parkinson’s disease (PD) patients. However, there is some research that suggests that GLP-1 receptor agonists (such as Ozempic) may have neuroprotective effects and could be used to slow the progression of PD1.It is important to note that you should not take any medication without consulting your doctor first. They will be able to provide you with the best advice on whether Ozempic is a good drug for you.

From Bing AI

[pvw2 in reply to Nicopwp]

But I would expect some PwP to have type 2 diabetes, and when PwP need to take a drug of an illness not PD, it is important to find a drug not detrimental, but better even beneficial fighting PD.

[gomelgo in reply to Nicopwp]

My understanding is that Ozempic is actually a peptide, not a drug exactly.