The need for sinemet/dopamine in general.

[beehive23]

I would suggest given responses / dialogue ive seen here that if you have been on sinemet every 3rhs 24/7 ish and you can stop with little or no effect.....you might want to question an idiopathic PD diagnosis. cheers...........hang tough.

[LAJ12345]

If you are referring to the book we were discussing earlier I think she said that you are more likeLy to become addicted if you don’t have Parkinson’s and take it , much like taking morphine when you don’t have pain.

[beehive23 in reply to LAJ12345]

sinemet response though is still a good bet you have pd if it alleviates symptoms......cheers

[sharoncrayn in reply to beehive23]

What study, medical research, or clinical trial confirms your hypothesis that: "is still a good bet you have pd if it alleviates symptoms.."

and exactly what is your "good bet" and how did you derive it?

Sharonn

[beehive23 in reply to sharoncrayn]

In addition to your examination, your doctor may give you carbidopa-levodopa (Rytary, Sinemet, others), a Parkinson's disease medication. You must be given a sufficient dose to show the benefit, as low doses for a day or two aren't reliable. Significant improvement with this medication will often confirm your diagnosis of Parkinson's disease. mayoclinic.org/diseases-con... Mayo.......

PD .net

Diagnosis – The Levodopa Challenge

By Editorial Team · March 8, 2017

SHARE

A levodopa challenge is a trial of the medication levodopa, given to patients if a confirmation of a diagnosis of Parkinson’s disease (PD) is needed. Levodopa is used in the treatment of PD and is effective in reducing the motor symptoms of the disease, including rigidity, bradykinesia (slowed movement and the loss of spontaneous movement), impaired balance, and resting tremor.

parkinsonsdisease.net/diagn...

i derived"" this from research and personal experience and what university colorado hospital neuro has said to me at appointment #1

cheers

[sharoncrayn in reply to beehive23]

Your research doesn't address the issue, your citations don't address the issue, nor does your personal experience nor does the opinion of your neuro,

As the Mayo note states: "Significant improvement with this medication will often confirm your diagnosis of Parkinson's disease."

Will often confirm "but not always" is my point, nor do we have a definitive probability of doing so (from any source) as you obtusely suggested earlier.

Your 2nd citation is totally irrelevant to the issue.

You should know by now people respond to PD drugs differently which is why we have so many drugs. Non-response only means they didn't respond to that specific PD drug...not that they don't have PD.

Sharon

[Hikoi in reply to sharoncrayn]

I think responsiveness to L Dopa therapy would be as accurate as any other method of assessing whether one has PD. But that is opinion not fact. I do not know of any definitive way of diagnosing Parkinsons Disease. Do you?

As to having many drugs I do not agree. We are limited. claiming there are (apparently) many drugs because of differing responses is an interesting drug development motivator but is it just your opinion.

[beehive23 in reply to Hikoi]

i agreee were limited in effective drugs.....but i guess people discussing personal experiences are irrelevent on this site. cheers.

[sharoncrayn in reply to Hikoi]

The L-dopa "challenge" isn't as valuable as a scan, but a definitive 99% method doesn't exist which is the issue. Personal opinion promoted as science is erroneous.

"As to having many drugs I do not agree. We are limited."

Sorry, but we have at least 15 drugs in the US off the top of my head. We have the drugs. They just don't work for everyone or forever. They are limited in their efficacy and probably always will be.

Sharon

[beehive23 in reply to sharoncrayn]

STOP HARRASSING ME.

[Hikoi in reply to sharoncrayn]

Try having PD and you will then know 15 isnt many. If you consider the drugs in types the picture of what is available is much more accurate. We have two treatments, dopamine agonista and levadopa. All the rest are just to enhance those drugs and try and increase their effectiveness. I DO NOT CONSIDER TWO TREATMENT DRUGS AS HAVING MANY TREATMENTS.

[beehive23 in reply to Hikoi]

Amen.

[chartist in reply to Hikoi]

I don't understand why dogs are not used more for the purpose of helping to confirm a diagnosis of PD. According to this news blurb, they can be as high as 100% accuracy which seems impressive compared to our current state of testing for PD. How often have you read or heard someone say that they were diagnosed as having PD only to later say that it turned out to be something else?

kiro7.com/news/local/washin....

Just think how much time and expense it would save!

Art

[beehive23 in reply to chartist]

thats a cool idea! i know only 1 peron misdiagnosed.....very cool article! cheers.

[beehive23 in reply to sharoncrayn]

Everything you said is your opinion.......not supported and ...i guess on this site is irrelevant........

i stand by what i cite and believe peoples personal experiences are not irrelevant . I am not irrelevant and university hospital neuro center Mvmnt docs explained it to me as diagnostic. i think your response is rude and cursory. you post is irrelevant. im feel bad your so angry.....they have pills for that...cheers.

[Hikoi in reply to beehive23]

As you can see beehive S Crayn hasnt a blue clue what it is like to suffer from PD. She is not a carer of a person with pd. i doubt she has spent 24 hours with someone with PD.

She positions herself as expert because she has an uncle with PD and she runs a couple of PD groups.

[beehive23 in reply to Hikoi]

i was wondering .......im a scientist Anthropology Geology minor in Bio and Zoo, im pretty ssure i can research effectively. im not always citing the newest best but i try not to be lazy.......cheers!

[beehive23 in reply to Hikoi]

my brother has pd, my uncle and my grandfather and my cousin all matrilineal........ive been around it a bit .......cheers

[beehive23 in reply to sharoncrayn]

so your suggesting"" that were all irrelevant? and yet you take the time to discuss said irrelevancy? This might help you....... Adj. 1. irrelevant - having no bearing on or connection with the subject at issue; "an irrelevant comment"; "irrelevant allegations". relevant - having a bearing on or connection with the subject at issue; "the scientist corresponds with colleagues in order to learn about matters relevant to her own research".

hope you feel better today...cheers.

[sharoncrayn in reply to beehive23]

Your opinion is not only erroneous but potentially harmful to anyone who is foolish enough to follow it.

Your citations (not mine) prove you are in error beyond any doubt. Therefore they are irrelevant when attempting to prove your point; they do just the opposite.

Please don't state your personal opinion without the caveat that it is your "personal opinion" and not validated by any scientific inquiry.

Cheers.

Sharon

[beehive23 in reply to sharoncrayn]

will IMO work cause thats what i usually use but you cant stop nor stifle MY OPINION which is YOU ARE HARRASSING ME.Will you please stop harassing me?

CHEERS

[blogger_7]

Hi beehive23 I just wanted to say, I don't respond to C/L It makes me throw up. But the neuros all want me to take at least 4 a day, any way. Yes, a datScan verified I have a significant loss of dopamine. But as everyone states, no two PwP are exactly alike.

[beehive23 in reply to blogger_7]

yes so they say. cheers!