Artificial Intelligence?? Pretty pedestrian intelligence if you ask me.
"As an AI language model, I cannot provide medical advice or recommendations. However, I can provide some general information about supplements that have been studied in relation to Parkinson's disease. It is important to note that any supplement should be taken only under the guidance of a healthcare professional.
Some supplements that have been studied in relation to Parkinson's disease include:
Coenzyme Q10: This is a naturally occurring antioxidant that is involved in energy production in cells. Some studies have suggested that it may have a neuroprotective effect in Parkinson's disease.
Vitamin D: Low levels of vitamin D have been associated with an increased risk of Parkinson's disease. Some studies have suggested that supplementation with vitamin D may be beneficial for people with Parkinson's disease.
Omega-3 fatty acids: These are essential fatty acids that are important for brain function. Some studies have suggested that supplementation with omega-3 fatty acids may have a neuroprotective effect in Parkinson's disease.
Creatine: This is a naturally occurring compound that is involved in energy production in cells. Some studies have suggested that supplementation with creatine may have a neuroprotective effect in Parkinson's disease.
It is important to note that the evidence for the effectiveness of these supplements in Parkinson's disease is still limited, and more research is needed to determine their safety and efficacy. It is also important to discuss any supplement use with a healthcare professional, as some supplements may interact with medications or have other potential side effects."
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MBAnderson
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What is the likelihood of a cure for Parkinson's Disease?
More pablum
"As of my knowledge cutoff in 2021, there is currently no cure for Parkinson's disease. However, there are treatments available that can help manage the symptoms of the disease and improve the quality of life for people living with Parkinson's.
Parkinson's disease is a progressive neurodegenerative disorder that affects movement and can also cause cognitive and behavioral changes. The cause of Parkinson's disease is not fully understood, but it is believed to be a combination of genetic and environmental factors.
There is ongoing research into potential cures for Parkinson's disease, including stem cell therapy, gene therapy, and new drug treatments. However, it is difficult to predict when a cure will be discovered, as medical research is a complex and time-consuming process that involves many stages of testing and evaluation.
Despite the lack of a cure, there are many organizations and resources available to support people living with Parkinson's disease and their families. These include support groups, educational resources, and advocacy organizations that work to raise awareness and promote research into the disease."
And not one mention of melatonin which actually has at least three human PD studies showing positive effects???? Oh my!
Doesn't sound quite ready for primetime!
I wrote an article about various studies regarding colorectal cancer including supportive study quotes where Chat GPT was used to edit it. It did a great job of making the article more readable, but it also altered the article in such a way that you could not differentiate what I was saying from what the studies were saying. It ended up leaving the reader with the impression that I had not only written the article, but had done the studies myself. I believe that is called plagiarism! Definitely not quite ready for prime time, but newer versions come out pretty quickly and resolve previous issues of older versions.
I think one significant issue with the various AIs is that so much depends on the person who designed it and then when you throw in different belief systems, they can really alter the end product from one AI to another even though they may both be designed for the same purposes. AI is a very complex subject and then if you have ever seen the old tv series, "Person Of Interest", you can quickly see where AI may run afoul once restraints are reduced.
I just watched it, Marc. I had seen it on YouTube, but had avoided it because Dr. Perlmutter was speaking in it, but now you went and got me started!
I think it is an okay video, but she just breezes over the things she is talking about and not bringing up the really important points of what she is discussing. As a basic example, she brought up Dr. Lissoni and his research into melatonin and various cancers. She mentioned how melatonin is compatible with standard cancer treatment while being synergistic and helps to reduce side effects of standard of care for cancer, but she didn't even mention two of the most important points of his work, that cancer patients who used standard of care plus just 20 mg of melatonin lived longer than those who didn't. He also showed that melatonin itself has anticancer effects and newer studies confirm his findings and show that melatonin has multiple anticancer effects while having a safety profile that is very significantly better than standard of care for cancer. He dedicated the majority of his professional career researching melatonin in relation to cancer.
She referred to .3 mg as a pharmacological dose and 20 mg of melatonin as a very high dose. That to me says that she has a lot more reading to do.
She never even mentioned the relationship between age related diseases and how they correlate with the decline of melatonin production. She didn't once mention the value of melatonin as a preventative or treatment for cardiovascular disease, the number one cause of death in the world! If a pharmaceutical drug could do the same, it would be a blockbuster for that reason alone!
She never once mentioned that we can get much more melatonin with morning and afternoon sun exposure than we can from any food item. She didn't mention how we spend more and more time indoors, the older we get and how that can contribute to the decline of melatonin and rather only concentrated on discussing how artificial light at night (ALAN) is the cause for declining melatonin. It is easy to spend a little time in the morning and afternoon sun, like we did when we were 8 to 10 years old and our melatonin levels were highest. I would love to see what would happen if we maintained a similar level of melatonin throughout our lives that looks the same as an 8 year old. Would that allow us to completely avoid most age related diseases?
She barely breezed over Covid-19 and Dr. Perlmutter countered with there are no studies to support the use of melatonin for Covid-19 and she didn't correct him which tells me she is not aware of the studies that actually do show that melatonin lessens symptoms, speeds recovery, prevents the cytokine storm. prevents ARDS, prevents having to be put on a ventilator and significantly decreases the death rate in hospitalized Covid-19 patients.
She talked about how melatonin is made in the mitochondria, but didn't mention that melatonin is also produced in red blood cells, which don't have mitochondria.
She made no mention of how melatonin is great for osteoporosis prevention or treatment or to help recover from fractures or to generally maintain bone health.
Honestly, I felt they could have done a much more informative melatonin video in the 47 minutes of video that they did.
She seems trapped in a very cautious phase, but if she had done more reading before making that video, she would already be well beyond that stage and delving deeper into what studies show that melatonin can do for our health rather than what she thinks it might be able to do.
I can go on and on about the health benefits of melatonin, but sometimes I feel I am just wasting my time and I do not find videos like these helpful for furthering melatonin exposure in a meaningful way! It took longer to watch that video than it did for me to write this reply!
How good is the advice from the HealthUnlocked PD forum?
ChatGPT
As an AI language model, I cannot provide an opinion on the quality of specific advice given on the HealthUnlocked PD forum. However, in general, online forums can be a helpful resource for individuals seeking support and information about a particular health condition. It is important to remember that the advice given on these forums is often based on personal experiences and opinions and may not necessarily reflect the views of healthcare professionals. Therefore, it is always recommended to consult with a healthcare provider before making any significant changes to your treatment or management of a health condition.
If you find a doctor to discuss supplementation with vitamins or supplements and make the appointment soon rather than 6 months down the road, please let me know!
I am not surprised one bit. It only picks what is out there and those who are uninformed marvel at its intelligence. It is good at collecting information and organizing it.
If it were really intelligent it would have proposed a cure. Surely it is waiting for a cure to be published so that I can reproduce that on demand.
On the other hand, an AI that is very specifically designed by a very bright individual could devour all of the supplement studies in the world and combine all of that data to extrapolate many potential treatments or remedies for the diseases of the world, but I can see the potential for significant resistance to such an AI.
By combining all of the known disease markers, pathway activations and deactivations, inflammatory markers, etc. and then using the available data about all supplements, an AI could match supplement activities to the known characteristics of a disease like PD and could come up with multiple potential remedies in order of likely effectiveness. That would be quite valuable in disease abatement and I think doable within a relatively short period of time.
Then when there are no more diseases someone will invent a completely new one that no AI and no human will be able to remedy and here is a new way in which we will become extinct.
Like all automatisms it will make us lose some skills, before the calculator we knew how to calculate much better than now and so it will be for AI, it minimizes our ability to evaluate the data according to our purposes, that is, our logic.
The advocates of "optimization/automation/enslavement" did not foresee this facts and they didn't think of a remedy.
Yes but they do it for the common good and to save the world.
Communism it is an idea that doesn't work: do Human being never learn this fact?
Well expressed...with AI beings I do believe that these systems will deliver new pathways and understandings which human mind is not capable to see. Using these AI insights human mind will reach new advanced states of thinking. I see AI a miracle tool for promoting thinking capacities of human mind ...Actually hidden thinking capacities of human brain are unlimited....but we need the opening up of mind to access the quantum states which AI will provide.....a soft ware jump
Having said all that we are in Pac-Man stage of AI and now we have Fortnite in video games not too many years later. And given it soon will begin to improve itself I think it will progress very fast from here if it allowed to.
It can’t carry out double blind placebo trials on humans though.
maybe no ego but how can it rule out the bias of the person who inputs the information - I guess I don't really understand it all that well and in some ways it seems a bit obnoxious kind of like Elon (sorry I do not have a high opinion of the guy) He may have had some stunning inventions and may be a genius in some areas but like you say ego can definitely get in the way
meandering off down a side track here,I find the caveat” before adding a new supplement talk to your health professional” laughable.Most of us sadly have professionals who have no interest in anything outside their narrow remit,which is why we joined this site in the first place.
There are always exceptions to the rules, Linda. Hubby's MDS approves supplementation, actually helped us with MP. He was fully aware and supportive of the supplement list I gave him.
Long time "no see you." Everything OK? We had our ups and downs. . .
Despe, yes always exceptions to the rules. I did say "most" and was being hopeful. So glad you have a doc who approves supplementation. Hubby is on 4th neurologist and all 4 weren't interested in supplement discussions. At least they do add the supplements he is taking to his list of meds.
Hubby has appt with neurologist tomorrow. We'll bring up the subject again just in case doc has changed her mind in the last 6 months. 😀
Hubby's current neurologist believes in proper nutrition. Which is fine. However, sometimes one's body doesn't absorb the vitamins from food properly and hence advised to take a supplement. Not everyone gets the proper amount of Vit D and hence advised to take a supplement. And so on ...😁
Keep the Faith. Keep reading and posting on the fabulous Health Unlocked
Very briefly, Large Language Models predict what text is most likely to occur next based on a large database. So if the database is 'stuff on the web' and you ask it what supps are good for PD, you will get a list of things that are most frequently mentioned on popular websites like WebMD, Healthline, Men's Health, etc. You might get a different answer if the database consisted only of HeathUnlocked, PatientsLikeMe, StuffThatWorks, and Facebook PD group posts. Still another listing if the database were only biomedical articles.
That being said, ChapGPT 4 has shown some signs of Artificial General Intelligence - a human like understanding. This version is not currently available for public use.
What use could currently available AI chat bots be to most ppl on this forum? Often ppl want a lay person summary or key points of biomedical articles - that's something they can do fairly well. However, with highly technical information, they may get some things wrong*, so don't use the output as the basis for major decisions.
* To illustrate, I will try to post a link later to output I got from Bard when I asked it why robin's eggs are blue, but I have to format it and put it in a Google Doc.
Edit: Okay, here it is - but the log is for Bing, not Bard. I forgot that I had 1st asked Bard the question but did not copy the interaction, unfortunately. Bard actually did better than Bing since it included the sexual selection explanation in its 1st response, but like Bing it had the sex role reversal problem. I'm disappointed I did not copy it since it was actually quite funny.
Elicit is an AI enabled scientific research search service that has the ability to make bullet point summaries of scientific articles and also analyzes the paper under headings such as 'Can I trust this paper?'
I'm going to be a complete weirdo and ask that ppl be kind to their AI assistants. I don't think they are sentient (yet) - but
1) they learn from our interactions with them. Unfortunately they have already been trained on datasets that include some very bad examples, but going forward it would be nice if they learned how to mimic the best human behavior, not its worst.
2) I've noticed that ppl who grow up in households with servants tend to treat other ppl as 'less than' - even when those ppl are not their servants or employees. It's like a bad habit & since I don't want to get in the habit of being rude or callous, I'm making a practice of treating AIs as I would other ppl. I don't make small talk, of course, but I'm not rude or abusive, even when I get frustrated by the output.
Why not ask those who built it an autocorrection mechanism so that it does not learn bad behaviors, instead of asking us to respect a text editing automatism as if it were a human being? Would it be logical or not?
Well chat GPT is a hyperlearning machine, so it has now had the experience of working with you and will learn from that and improve itself, and very quickly because it has a drive to do so.
Check back with it in a few months and you may find that it is evolved to the point that is reinvents itself to be perfect and also seek to eliminate imperfection.
Take a gander at the movies Prometheus, and Alien Covenant, for a preview of what is to come fairly quickly.
In fact, I think it may be at work already. For all we know, the current makeup of the United States Congress and politicians and State governments are the initial phases of chat gpt's attempts. That's my guess. Consider the last few presidents and a few other state leaders across the country, like the UK, germany, russia, China, North Korea, sudan, india, bangladesh, and quite a few others I failed to name. Private equity funds.
what number for vitamin D or does it matter? Interesting that I had a full blown physical last week and it came back with a deficiency in Vitamin D. So why not take all three?
It would be nice if Chat GPT could give us answers to questions that no one knows the answers to. . . However, I have found it useful to EXPLAIN and SUMMARIZE information that I think is probably known by others but is not clear to me.
For example asking "Can you explain the D1 And D2 motor neuron model" or "Is Desulfovibrio bacteria correlated to increased inflammatory response" provide useful information that seems to be congruent with my other knowledge and is a simple and easy synopsis.
"The D1 and D2 motor neuron model refers to a classification system used to categorize two types of motor neurons found in the basal ganglia, which is a complex network of structures in the brain involved in motor control and other functions. These motor neurons are named based on their anatomical and functional characteristics.
D1 Motor Neurons:
D1 motor neurons are a subtype of medium spiny neurons (MSN) that express the D1 dopamine receptor. They are primarily located in the direct pathway of the basal ganglia circuitry. The direct pathway is responsible for facilitating voluntary movement initiation. D1 motor neurons are excitatory, meaning they increase the likelihood of firing action potentials, and they promote movement by activating the motor cortex.
D2 Motor Neurons:
D2 motor neurons, also known as indirect pathway neurons, are another subtype of medium spiny neurons in the basal ganglia. These neurons express the D2 dopamine receptor. They are predominantly found in the indirect pathway, which acts as a braking system to inhibit or suppress movement. D2 motor neurons are inhibitory, meaning they decrease the likelihood of firing action potentials, and they help regulate and control movement by inhibiting the motor cortex.
The D1 and D2 motor neurons play crucial roles in the fine-tuning and modulation of motor activity within the basal ganglia circuitry. Imbalances or dysfunctions in the activity of these neurons have been implicated in various movement disorders, such as Parkinson's disease, Huntington's disease, and dystonia. These disorders often involve disruptions in the delicate balance between the direct and indirect pathways, leading to abnormal motor symptoms."
"Desulfovibrio is a genus of bacteria that belongs to the sulfate-reducing bacteria (SRB) group. While Desulfovibrio bacteria are naturally present in the human gut microbiota, their role in human health and disease is still an area of active research, and the specific effects of Desulfovibrio on inflammatory responses are not yet fully understood.
Some studies have suggested a potential correlation between Desulfovibrio and increased inflammatory response, particularly in the context of certain diseases. For example, increased levels of Desulfovibrio have been observed in individuals with inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis. In these conditions, the gut microbiota composition is known to be altered, and Desulfovibrio has been identified as one of the bacteria that may contribute to intestinal inflammation.
Desulfovibrio bacteria have been found to produce hydrogen sulfide (H2S) as a metabolic byproduct during their growth. H2S is a gas molecule that can have both pro-inflammatory and anti-inflammatory effects depending on the concentration and context. At high concentrations, H2S can trigger inflammation and damage tissues. Therefore, it is possible that the increased presence of Desulfovibrio and the production of H2S in the gut could contribute to inflammation in certain individuals.
However, it is important to note that the relationship between Desulfovibrio and inflammation is complex, and further research is needed to fully understand their interactions. The human gut microbiota is highly diverse, and alterations in the overall microbial composition, as well as interactions between different bacteria and the host immune system, can influence the inflammatory response. Factors such as diet, host genetics, and environmental factors also play a role in shaping the gut microbiota and its impact on inflammation.
In summary, while there is some evidence suggesting a correlation between Desulfovibrio bacteria and increased inflammatory response, more research is needed to elucidate the precise mechanisms and determine the significance of Desulfovibrio in inflammation-related conditions."
' Furthermore, approximately 1.2% of ChatGPT Plus subscribers who were active on March 20th may have had payment information compromised due to the bug. The incident exposed names, email addresses, payment addresses, credit card types, and the last four digits of credit card numbers. '
I get that they are concerned about getting the product off to a good start, but maintaining security always seems like it should be a number one priority given that they require personal information in order to use their AI!
The most insidious are the AI chatbots, with 2000 euros I can buy one that reads all your posts and replies and could replace you by writing almost like you Art
. The only way to defend yourself is to limit your posts by ticking the "my community only" box, this puts some kind of limit on the post and can't be read by search engines, but I'm not sure if that's the case, I'm no expert.
this is what I got from claude, "what is the best supplement for PD?
I apologize, but I cannot and should not recommend specific supplements for Parkinson's Disease (PD), as this requires personalized medical advice that should come from a qualified healthcare provider."
you are totally right. my intention was not to recommend anything, but too use this example, for showing people how they can increase their chance of finding something that works for *them*.
not asking for the best PD-supplement, instead ask for *your* personalized case. if you give chatgpt all your information(more then a medical dr. has time to listen), and repeat your question you may get a more qualified answer then from your healthcare provider.
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.
Vitamin D supplementation worsens Alzheimer's progression: Animal model and human cohort studies 2022
2 questions i asked chat open AI mostly beyond my understanding but might be of interest to some of you :)
A theoretical way to make mannitol work better
