If correct ....wow !: helsinki.fi/en/news... - Cure Parkinson's
If correct ....wow !
Supplemental cystine included in the casein and AA diets, and often used in human nutritional products, may provide a substrate that directly promotes the growth of Desulfovibrio.
Effective treatment options for Desulfovibrio desulfuricans infection include clindamycin, carbapenem, and metronidazole
Do you know the dosage and for how many weeks please?
I don’t really know and I wouldn’t recommend before consulting with a GI consultant . It’s not that simple.
What is the AA diet?
This diet substitutes milk and soy formulas with a low-fat, elemental, free-form amino acid formula, made from nutrients in their most broken-down form that requires very little digestion.
This sounds similar (just in theory, I don't know the details of the AA Diet) to the Specific Carbohydrate Diet. No complex carbs as they can't be easily digested and linger in the intestines to feed bad bacteria. SCD as been shown in small studies to normalize the microbiome.
Desulfovibrio is a genus of gram-negative sulphate-reducing bacteria. This genus has been positively correlated to IBD, colorectal cancer (in animal model), ulcerative colitis, liver disease and autism.Desulfovibrio spp. is predominant member of Sulfate-reducing bacteria in human gut microbiota. Sulfate-reducing bacteria (SRB) are anaerobic microorganisms that conduct dissimilatory sulfate reduction to obtain energy, resulting in the release of a great quantity of sulfide. They are commonly isolated from environmental sources, but are also present in the digestive tract of animals and humans. Different species of Desulfovibrio: Desulfovibrio desulfuricans, Desulfovibrio piger, Desulfovibrio fairfieldensis Desulfovibrio legalliiThe bacteria produce hydrogen sulfide (H2S), a metabolite which can influence cell signaling and reduce oxidative stress at low concentrations and pose toxicity at higher concentrations.
What is hydrogen sulfide? Hydrogen sulfide is a colorless, flammable gas that smells like rotten eggs at low concentration levels in the air. It is commonly known as sewer gas, stink damp, and manure gas. At high concentration levels, it has a sickening sweet odor.
EXCESS HYDROGEN SULFIDE SYMPTOMS
Patients with excess hydrogen sulfide share common symptoms with SIBO: abdominal pain, bloating, gas, distension, flatulence, but especially diarrhea. Levels of hydrogen sulfide, as measured by a breath test, correlate with the severity of diarrhea.
Okay so my husband tested positive for SIBO initially and he had constipation but not to the extreme he was more troubled by feeling full all the time and pain which was probably attributable to GERD however both of these seem to have been corrected by natural treatments
Beef, eggs, pork, fish, and poultry are rich in sulfur, which can be turned into hydrogen sulfide by gut bacteria, resulting in foul-smelling gas that is reminiscent of rotten eggs. Protein supplements may also contain ingredients that cause flatulence and encourage excessive wind.
How do we get rid of it ?Or at least the spoiled versions ...
The best way is to discuss it (if having symptoms) to a GI consultant.
is there a test to see if I have these bugs in my gut?
Not really sure but could be via endoscopy and taking samples or feces analysis test.
I had the G.I. Effects test by Genova ordered by my functional medicine doctor last fall. My Desulfovibrio Piger was listed as below detectable level. The other Desulfovibrio species were not tested for. At least I can rule out one of them as a problem! The test is generally not covered by insurance and runs several hundred dollars.
The SIBO test is a breath test and can be ordered by a GI doctor but not sure if all of them would be willing to do it or if it would be covered by some insurance programs
Wow
I have always thought my parkinsons started in my gut many gut and digestion problems, thank you for this post
To directly target Proteobacteria, you first need to identify the specific bacteria that are overgrown.
The most common Proteobacteria overgrowths are Desulfovibrio, Sutterella, Parasutterella, Bilophila, Klebsiella, and Escherichia.
In clinical practice, the following therapeutics may lower these bacteria:
Sutterella: berberine, Bacillus subtilitis probiotic
Parasutterella: berberine, Bacillus coagulans probiotic
Klebsiella: berberine, neem, oregano, thymeEscherichia: berberine, neem, oregano, thyme
▶️ Desulfovibrio: codonopsis, garlic, inulin, Bacillus coagulans probiotic
Bilophila: chamomile, garlic, inulin, Lactobacillus rhamnosus GG probiotic
Certain supplements may increase these bacteria. Watch out for:
Sutterella: triphala, slippery elm, GOS, psyllium m
Parasutterella: licorice, triphala, GOS, lactobacillus acidophilus probioticKlebsiella: GOS, licorice
Escherichia: slippery elm
▶️ Desulfovibrio: berberine, licorice, slippery elm, Bacillus subtilitis probiotic
Bilophila: berberine, Bacillus subtilitis probiotic
It is important to note that many of the antimicrobial herbs (berberine, neem, oregano, thyme) may decrease beneficial bacteria like Bifidobacterium and butyrate producers, especially if used at high dose and for long term. You may be able to mitigate these negative side effects by using prebiotics and other tools to support those beneficial species while on antimicrobials. But make sure you are not working at cross purposes. For examples, don’t use GOS to feed Bifidobacterium if you are using berberine to decrease Sutterella. As you can see, it can get complicated so it is recommended to work under the supervision of an experienced practitioner. If you want to use indirect strategies to decrease Proteobacteria, nutrition and prebiotics are the best tools. Here are some basic nutrition recommendations:Decrease fat intakeIncrease fiber intakeIncrease polyphenol intake: blueberries, cherries, strawberries, blackberries, plums, red apples, grapes, chestnuts, hazelnuts, pecans, black tahini, purple carrots, red carrots, purple potatoes, cabbage, spinach, red onions, broccoli, orange carrots, red lettuce, red rice, black rice, red and black quinoa, black olivesIncrease prebiotic intake: garlic, onions, leeks, asparagus, artichokes, legumes, beets, sunflower seeds, pumpkin seedsIncrease prebiotic-like foods: brown rice, almonds, cacao, green teaLactulose and fructooligosaccharides (FOS) may be helpful prebiotics to use. But use prebiotics with caution as they may feed certain Proteobacteria. Once you start a prebiotic, retest your microbiome within 2-4 weeks to make sure Proteobacteria levels are not going up. Also, do not use prebiotics if you have small intestine bacterial overgrowth (SIBO). With all prebiotics, it is best to start low and to start slow. Increased gas is a normal reaction to prebiotics, but significantly increased abdominal distention and bloating is not. Please talk to your practitioner before changing your diet or starting any new supplements or medications.
biomesight.com/blog/managin...
Wow....... the multiple angles,would indeed require expertize... thank you for sharing your insight and extent of knowledge..... the diet seems like a far more complex subject, than "protei is protein and the body will cope" like I heard one expert say on YouTube the other day. It seems to me different people need different approaches.....
Thanks for sharing that biomesight web page. Interesting. I need to get licorice extract back into my diet. I pound the berberine 1200 mg a day. Probably not wise (HS Education, poor impulse control), so kids don't do like me.
I go for Neem and Turmeric. berberine and licorice extract are both good supplements but they didn’t work for me.
I have a gram of curcumin twice a day. There is a study that this dose will reduce a-syn in your skin test (which sounds pretty darn good).
The Correct Curcumin for Used in "The Effect of Curcumin on Idiopathic Parkinson Disease: A Clinical and Skin Biopsy Study" healthunlocked.com/cure-par...
I’m thinking the FODMAP diet might be worthy of consideration?
Another disappointment.
We have known for decades that gut health is critical for prevention of and recovery from all chronic disorders.
If we ensure that our digestion is efficient, food supply wholesome and devoid of inflammatory foods like animal dairy, grains, artificial additives and sugar, then pathogenic bacteria will not thrive. If there is overgrowth, there are proven effective non-pharmaceutical strategies to correct dysfunction.
It is disgracefully sad that the majority of research money is focused on selective processes, generally well known in Complementary Medicine circles, that have the potential to create enormous profits for a few companies, while more general strategies that have been proven in private research over many decades is ignored.
The aim of this research is to find a drug target and create a new drug to make 20 billion dollars profit in the first year of manufacture.
Seems odd MJF hasn’t figured this out in 23 years of existence. Oh well, we’ll take it. I’ve always had gut problems, the opposite of constipation. I’ve been drinking Kefir and eating a lot of yogurt lately. and my gut feels a lot better. * I haven’t been diagnosed yet, but told I’m high risk because of rem sleep disorder.
There are thousands of bacteria in the gut, so its problematic. I had similar isssues...if I include meat in just a single meal per day the digestion is fine, if not, well then not 
See this video : youtube.com/watch?v=rcbx7O1...
i was so excited to read this but it seems to have gone quiet. Do people think its not right or are we all busy trying to work out how to reduce the bacteria and testing the theory?
For me, the main problem is that the University of Helsinki press release was a bit "over the top". There are some more-sober articles available now, such as this one from MNT.
ncbi.nlm.nih.gov/pmc/articl...
"However, none of the strains tested were resistant to imipenem or metronidazole; these should therefore be considered the drugs most suitable for treating infections caused by Desulfovibrio spp. "
Both antibiotics are practically available in every country in the world! I already have it on the table to try... (Google search is your friend.)
Willingly. 
This is very interesting. I hope trials on this discovery starts soon. The timescale of when results are ready for such trials, is hopefully not too long
I'm not waiting for years, I have the antibiotic here, you can try it without risk....
I will try everything that can be undertaken with a reasonable risk.
Please share, especially if you experience change. I am very interested
If taking metronidazole, avoid alcohol. It can be seriously unpleasant. And you are going to badly mess up your microbiome. My parkinson's disease symptoms started after a course of metronidazole. When you've been around a while with PD you learn that people are not mice, fruit fly or worms.
im trying to eat low sulphur food, exercise hard and take curcumin supplements. Done this for the last 10 days and feel better but could be placebo. V hopeful to hear how kwisatz does on his antibiotics.
It's here on the table, but I haven't started the "clinical trial" yet because I've started testing the bHaptics gloves, but I'll let you know when I do.
Maybe it's not an entirely unfounded thought, although I didn't look into it, that doxycycline also worked a few years ago.
my symptoms are staying very low on a plant based diet minus certain high sulphur vegetables. Maybe there really is something to this….
my symptoms are staying very low on a plant based diet minus certain high sulphur vegetables. Maybe there really is something to this….
I am using Rife frequency therapy to treat Lyme disease and co-infections. My PD symptom’s began with gut dysbiosis, severe constipation after a tick bite. I just looked at the software for my frequency generators and there are frequencies for many strains of desulfovibrio bacteria. I believe I can do a biofeedback scan to see if I have any of these strains and then kill it. Thanks for the info.
What results have already achived ?
Great information and here's more
Here are some similar articles on Parkinson's disease and the gut:
1. [The Gut and Parkinson's Disease - A Bidirectional Pathway](frontiersin.org/articles/10... This article discusses the bidirectional communication between the gut and the brain, and how it may play a role in the pathogenesis of Parkinson's disease.
2. [The Gut Microbiota and Parkinson's Disease](ncbi.nlm.nih.gov/pmc/articl... This article provides a comprehensive review of the current understanding of the role of the gut microbiota in Parkinson's disease.
3. [Gut Feelings About Parkinson's](scientificamerican.com/arti... This article from Scientific American discusses how changes in the gut could trigger this degenerative disorder.
4. [Parkinson's Disease May Begin in the Gut](scientificamerican.com/arti... This article discusses research suggesting that Parkinson's disease may start in the gut and spread to the brain via the vagus nerve.
5. [The Gut-Brain Connection in Parkinson's Disease](michaeljfox.org/news/gut-br... This article from The Michael J. Fox Foundation discusses the gut-brain connection in Parkinson's disease and the potential for new treatments.
Please note that these articles are for informational purposes only and should not be used as a replacement for professional medical advice.
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