How can I be sure the renewal of my Rx is correct/

[willowone123]

Last week I picked up my refill of C/L 25-100, and the difference in performance seems to be more than just the normal progression of the disease. Tremors more prevalent and pronounced, longer periods of dyskenesia,marked increase in lethargy, etc. I checked the manufacturer's recall website, and the only recalls of the product were in 2020 and 2021. Do I contact the pharmacy?

Thank You

[park_bear]

Yes contact the pharmacy - they may have switched the manufacturers. Many have reported different results from different drug manufacturers.

[willowone123 in reply to park_bear]

I will do that! Thank you

[Smittybear7]

I had a similar experience and the pharmacist said they get the c/l from various places. I guess if you asked your neurologist to specify a certain generic brand. Good luck so far I am stuck with what they give me.

[willowone123 in reply to Smittybear7]

thank you

[Boscoejean]

"A generic drug may have certain minor differences from the brand-name product, such as different inactive ingredients.""Why 2 different brands of the same drug work differently?Several different companies may make the same generic drug, too, but they might use different filler ingredients. So their medications could have slightly different rates of absorption or cause different side effects. If you're happy with how a generic drug works for you, find out who the manufacturer is." (so I suppose if it does not work well you want to find out the manufacturer on that version as well and avoid it.

[willowone123 in reply to Boscoejean]

Thank you

[LagLag37]

That’s happened to me before. After I figured it out I just had to tell my doctor and my pharmacist to specify the particular manufacturer on the prescription and it took care of the side effects. 🥊🤗

[willowone123 in reply to LagLag37]

good advice. Thank you

[jrg54321]

What was the manufacturer?

[willowone123 in reply to jrg54321]

Mayne Pharma. They recalled C/L 25-100 in 2020 and 2021

[jrg54321 in reply to willowone123]

Mayne Pharma cl disagreed with me too. I was very mucousy using it. Mayne is the preferred provider for CVS. I had my MD specify a different manufacturer on the prescription. My problem went away.

[Gcf51]

I question if my current generic C/L is as potent as before. It is making me question if High Dose Thiamine (HDT) really halts or slows progression of PD since I am now requiring 50% more. Since the amount of a dose C/L (that makes it to the brain is only 5-10%* of the dose) it is easy to assume that one generic may fall less than 10% and that a few percentage points can may a huge difference.

* amount of levodopa that reaches the brain to about 1% of an oral dose… The two available inhibitors are carbidopa… and benserazide... Inhibition of the peripheral metabolism of levodopa increases the amount that crosses the blood brain barrier to 5–10% of the oral dose. sciencedirect.com/topics/me....

[Gcf51 in reply to Gcf51]

Do you trust the FDA is really testing all generics......

Any generic medicine must perform the same in the body as the brand-name medicine. fda.gov/drugs/frequently-as...

[willowone123 in reply to Gcf51]

Thank you

[HugoRipanykhazov]

Long shot but check the bottle that they haven't given you ER

[willowone123 in reply to HugoRipanykhazov]

Thank you. It is standard C/L - not ER