Researchers led by KBI_UHN Drs. Robert Chen and Ghazaleh Darmani shed light on the long-term effects of #deepbrainstimulation on brain activity in people with #parkinsondisease, laying the groundwork for improved therapies
The team discovered that deep brain stimulation increased aperiodic beta activity over time. In contrast, beta oscillations were stable over time.
These findings call into question the traditional view that deep brain stimulation treats Parkinson symptoms by reducing beta oscillations in the basal ganglia, and highlight the need to consider different forms of neuronal activity when studying the disease and developing therapies.
The researchers also found that dopaminergic medications that are commonly used to treat the disease affect these two types of brain activity differently. These medications did not affect aperiodic beta activity but did suppress beta oscillations.
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