Judge rules to invalidate two NR patents in win for Elysium Health - Looks like cheaper NR should be available

[Bolt_Upright]

Looks like cheaper NR should be available

Judge rules to invalidate two NR patents in win for Elysium Health

24-Sep-2021 By Stephen Daniells

US Judge Colm Connolly, United States District Court for the District of Delaware, has granted the request from Elysium Health to invalidate two Dartmouth College patents licensed by ChromaDex relating to nicotinamide riboside.

nutraingredients-usa.com/Ar...

CAFC Says ChromaDex Patent Claiming Isolated Form of Vitamin B3 Fails Under 101 Feb 13, 2023 ipwatchdog.com/2023/02/13/c...

The U.S. Court of Appeals for the Federal Circuit (CAFC) today issued a precedential decision affirming a Delaware court’s grant of summary judgment for Elysium Health that the asserted claims of ChromaDex, Inc.’s patent on an isolated form of vitamin B3 are directed to unpatentable subject matter under Section 101. Judge Prost authored the opinion.

U.S. Patent No. 8,197,807 is titled “Nicotinamide riboside kinase compositions and methods for using the same.” Nicotinamide riboside (NR) is a form of vitamin B3 that is naturally present in cow’s milk. The invention covers a composition containing isolated NR that results in increased biosynthesis of the coenzyme nicotinamide adenine dinucleotide (NAD+) upon oral administration.

ChromaDex sells dietary supplements embodying the patent, which it licenses from Dartmouth College, and sued Elysium for patent infringement in 2018. Elysium moved for summary judgment that the claims were invalid under Section 101 and the district court agreed, finding that the claims were directed to a natural phenomenon, specifically, “compositions comprising isolated [NR], a naturally occurring vitamin present in cow milk.”

[Gioc]

Is there anyone who patents water?

[Despe in reply to Gioc]

😂👍

[reedboat2]

Bolt I heard about some research indicating NR could be carcinogenic. Do you have any information on that? Thanks - JG

[reedboat2 in reply to reedboat2]

i’ll reply to my own question. I called Life Extension. They said they’re fielding a lot of questions on the subject. It seems a mouse study was published in November 22. It was a small study, and the results were questionable. LE does not consider it significant to the use of NR.

[Gioc in reply to reedboat2]

sciencedirect.com/science/a...

[reedboat2 in reply to Gioc]

In Vivo noninvasive bioluminescent imaging, how cool is that!

[Gioc in reply to reedboat2]

🐹🐹🐹 Poor mice,

However, I always prefer the good, healthy, old B3 NA at human doses.

ncbi.nlm.nih.gov/pmc/articl...

Quote:

“… Nicotinic acid (NA) (also known as niacin or vitamin B3) is extremely important for neuronal defence and neuronal death, 28demonstrating the importance of NA in healthy central nervous system function and neural and neuronal developmental pathways. Interestingly, NA was able to elevate tissue NAD levels more than NAM could and also was able to raise cellular NAD levels above what NAM could achieve. …”

[Despe in reply to Gioc]

NA it is, Gio!!!!

[rescuema in reply to reedboat2]

At least two mechanisms I could think of to be wary of when it comes to high-dose B3 forms or NR - it could potentially lead to copper deficiency and also interfere with methylation, both of which may be associated with an increased risk of cancer.