"[Researchers] have found that nicotinamide riboside can increase energy levels in the brains of people with Parkinson’s in a small pilot study [NADPARK] and they are now testing this agent in a longer term study [NOPARK] to determine if it can impact the progression of the condition."
The much larger NOPARK trial is not scheduled to complete until mid-2024. Rather than wait for that, I'm planning to buy some Tru Niagen to try for myself.
I agree with you, Jeff. Thanks to several posts by Sunvox (Joe Peck), I have been taking Tru Niagen every day since the Summer of 2018. healthunlocked.com/cure-par...
Hi, Bolt! Ironically, you asked me more or less the same question 5 months ago when I posted about TruNiagen. Click the link on my comment above to see your question and my reply. Also, see my reply to Smittybear7 below.
Thanks Jim! That was a great answer "I don't feel like my PD has progressed at all in the 3.5 years since my diagnosis. That's a long winded way of saying I have no idea if TruNiagen slows progression...but even with the significant cost, I think it's worth trying because of stories like the one linked to this post. "
I doubt that anyone else cares, but that's only part of my answer. I think the second part of my answer (which you copied and shared) has to be shared with the first part. I HOPE TruNiagen delays progression, but there is no way to know. I am always extremely skeptical about any claim that a particular supplement delays progression because (1) We have no way of knowing how we would be doing without a particular supplement, and (2) Most of us take so many supplements that's it's impossible to ascribe any perceived benefit to any particular supplement. The first part of my reply is more important to me than the second part which you shared. My ENTIRE reply was:
Hi, Bolt. One of the difficulties in assessing the effectiveness of any supplement is that it's impossible to know how we would be doing without it. I don't know how quickly I would be progressing without it. It's compounded by the fact that I take multiple supplements. Is it the B3, the B12, the B1, the D, the red light, the Neuroaspis, the butyrate, or the exercise? Finally, and probably most significantly, the progression of PD is normally so slow that it's unnoticeable from day to day, month to month, or even year to year, at least for me. Other than having foot dystonia about a year after diagnosis (which totally disappeared with Sinemet), I don't feel like my PD has progressed at all in the 3.5 years since my diagnosis. That's a long winded way of saying I have no idea if TruNiagen slows progression...but even with the significant cost, I think it's worth trying because of stories like the one linked to this post. 😊
No worries whatsoever! You didn't put me through anything. Actually, you may have inspired a future post encouraging people to take claims of slowing or stopping progression with a ton of salt. 😊
I share your concern and will likely skip it. If a simple request for kindness can be come controversial, I don't want to know what a request for caution and skepticism might engender.
I always sit up and take note when Simon Stott reports in SoPD say a phaseII or III is starting. The scientist in me tell me to wait for the published results. As a PD fighter I think.... I don’t have the luxury of time to wait for the results! Do you mind my asking what dose of Nicotinamide riboside you’ve been taking ? Thank you
I am also a big fan of Simon Stott. As a result of the Science of Parkinsons post which is linked below, I have been taking Neuroaspis. Again, I don't sense any particular improvement, but I hope it slows progression of Parkinson's Disease in the long run.
Hi Jim, I'm returning to Tru Niagen after tryng Nuchido (it increased my tremors, possibly due to being too energized). I have some questions for you, sorry: which B-complex are you using and what is your daily dose; you take Omega 3 only with Neuroaspis or even alone; what is your daily dose of Neuroaspis? Thank you very much.
I take 3 Apex Super Methyl capsules daily. I buy them from my chiropractor. See link below for ingredients and information. I take one serving of Neuroaspis daily because that's all that was given to patients in the trial referenced by Simon Stott. Here's a link to info regarding Apex Super Methyl:
I don't think it alleviates any symptoms which already exist. I look at Tru Niagen and virtually all other supplements with the HOPE that it MIGHT delay or prevent the worsening of symptoms in the long run.
I have my husband on Tru Niagen 2 tablets every morning for the last month in his stack of supplements. Certainly no adverse effects and he is doing quite well. Any opinions on whether we should increase the dosage ? Thanks
Tru Niagen comes in 100 mg or 300 mg capsules. I buy the jars with 300 mg capsules and take 3 per day (900 mg) because it is close to the 1,000 mg/day given to the trial participants. Again, I don't expect any discernable improvement, but I hope it provides a long term benefit.
Thank you. In the trial, they divided the doses in half, but I take it all in one. I usually take three 300 mg capsules first thing in the morning on an empty stomach.
Perhaps the question to ask is, do you feel better with Tru Niagen than before?
Are you better than before?
And if you are not better, are you worse than before?
And if you are not better or worse, it means you are stable.
Stable is good.
My greatest fear is things going south.
My husband is better with PS 128+K21, Coronet Duo, B vitamins, 250 mg niacin, curcumin, Honopure. Have you tried PS 128? You can order it from wellbeingsg.com
They have a promotion buy 10 get 2 free.
I will also be adding micronised PEA to our stack when it arrives.
Thanks, Millbrook. I'd say I'm stable, which is fine with me. Red light coronet, neuroaspis, high doses of a B complex (particularly high in B2, B6, and B12) vitamin, high doses of B1 and Tru Niagen is what I have settled on. Those supplements, together with Sinemet, have made life quite normal for now. That is as much as I dare hope for.
Thanks for sharing this. Sounds like it’s shown some good results. Agree with above comments it’s difficult to know when taking many supplements which one helps. Not sure I’m adding it to the stack yet though.
Has anyone tried NMN from Do Not Age? I used two bottles of it at 1 gram a day. I then switched to Tru Niagin 750 mg a day and 250 mg of niacin. I have less energy than when I was taking NMN but I don’t know if that is why.
I have not yet read the study but previous research has suggested that the vast majority is methylated in the liver for excretion....I wonder what % actually makes it to the blood plasma. In addition, I wonder how they measurs NAD levels given it's instability as it is constantly cycling between reduction and oxidation reactions
It was Simon who made that comment in his SoPD blog post. Here is a link to the comment section of his blog post, if you would like to ask your question there:
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