What are your thoughts on RELYVRIO previously known as AMX0035? Could it benefit PD patients as well?

Amylyx Pharmaceuticals Announces FDA Approval of RELYVRIO™ for the Treatment of ALS (September 29, 2022).

AMX0035 is a Fixed Combination of Phenylbutyrate (PB) and Tauroursodeoxycholic Acid (TUDCA). Many studies showed TUDCA is beneficial for PD.

RELYVRIO (previously known as AMX0035 in the U.S.) is an oral, fixed-dose combination therapy for the treatment of adults with ALS

RELYVRIO significantly slowed the loss of physical function in a randomized, placebo-controlled clinical trial in ALS

alzforum.org/therapeutics/r...

amylyx.com/media/amylyx-pha...

youtube.com/watch?v=Cr_fovl...(Not working as expected?)

PB Phenylbutyrate

PB was also reported to protect against neurodegeneration in models of α-synuclein toxicity and Parkinson’s disease (Sturm et al., 2016; Ono et al., 2009).

UDCA/TUDCA

The UP-Study confirmed UDCA is beneficial to PD.

healthunlocked.com/cure-par...

TUDCA reduced amyloid deposition and improved cognition in APP/PS1 mice (Nunes et al., 2012). It also improved pathology and behavior in mouse models of Parkinson’s disease, HD, and ALS (reviewed by Ackerman and Gerhard, 2016).

[gaga1958]

My functional doctor has me taking tudca and sited the ALS study. However, it is not a script, it is a supplement. I am taking the BODYBIO brand, 2 capsules, 2x/day @ 500mg each, so 4 caps daily.

[Hidden in reply to gaga1958]

I think your dose might be ok. The UP study is using dose to 30 mg/kg of udca in my case it is 90*30= 2700 mg per day.

clinicaltrials.gov/ct2/show...

[gaga1958 in reply to Hidden]

mine would be 56.7x30=1701 and I'm taking 2000mg

[Hidden in reply to gaga1958]

Do you notice any benefits by using tudca?

[gaga1958 in reply to Hidden]

no but I haven’t been on it long, maybe 3 weeks so far. But I tend to view supplements as a long term benefit and not judge it in the short term.

[Hidden in reply to gaga1958]

The UP study evaluated people after 48weeks which is almost a whole year.

[mellebrewer in reply to gaga1958]

Hi! I’m just curious what your thoughts are on the TUDCA now, after 6-7 months. Would you recommend it?

[gaga1958 in reply to mellebrewer]

I have not noticed any benefit per se, but it’s hard to know what symptoms, or lack there of attributed to which supplements.

My functional doctor says that he’s read the number of studies saying that it’s great for neurological diseases like ALS and Parkinson’s and encouraged me to double my dose so that it was the same dosage as the studies.

I just dbled so we’ll see. What I am, hoping for, is just slower progression, right? I was diagnosed in October 2014 and I think I’m doing pretty well and unless you really knew me personally you wouldn’t know I had Parkinson’s if you saw me at the store or on the street.

Have you started taking it yet?

[gaga1958 in reply to mellebrewer]

I took a short break from supplements last year, and when I started my supplements back up, I accidentally only took this Tudca once a day instead of twice a day, so I was not getting the full dose that I originally was prescribed. So that’s why the doctor encouraged me to double my dose back to what it was supposed to be.

[gaga1958 in reply to Hidden]

Did you see this post?

healthunlocked.com/cure-par...

[mellebrewer in reply to gaga1958]

Yes, I apologize- I just now had a chance to sit and read it. Thank you so much for your update. I’m actually taking taking care of my father who was diagnosed two years ago (but has probably had P for about 4 years) and just read a positive article on TUDCA. So, I was curious what your experience had been. He’s on some traditional medications, but I’m a big believer in functional medicine and am always on the lookout for new things to try.

It sounds like you have a great doctor who has you on an effective protocol. That’s wonderful! I hope your new dose continues to keep everything in check (and, hopefully, even improve some things for you)!

Thank you, again. -Melissa

[gaga1958 in reply to mellebrewer]

Did you already see this ?

healthunlocked.com/cure-par...

[mellebrewer in reply to gaga1958]

I didn’t - thanks!! I’m going to get my dad on it this week. We’ll see…!🙂

[Hidden]

Sydney75 you might be interested in this thread.

[gaga1958]

also functional dr also recommends

Butyrate for same reason