What is AMX0035, and Why Is It Important for All of Us?

[SilentEchoes]

AMX0035 is a drug combination of sodium phenylbutyrate (PB) and tauroursodeoxycholic acid (TUDCA). It works by regulating the mitochondrial (cell power supply) and endoplasmic reticulum (quality control centers). Put simply, both processes should work in unison, but when they don’t, cells in the body die, and internal, neurological inflammation develops. AMX0035 regulates cells in the body to prevent the stress that kills those cells and prevents neurological inflammation from developing. This might sound familiar to you with any neurological disease or trauma.

Why this drug is important to everyone with neurological disease and trauma? You might be thinking that you don’t have ALS, so how could this discovery be important to you. In the study of neurological disease and trauma, what works in one area of study often is translated into other areas. Some clinical trials are considering AMX0035 in the treatment of Alzheimer’s Disease and Parkinson’s Disease. Phase II of the study of AMX0035 and ALS has produced some excellent results. Because ALS has no known cure, the drug is going to be released for people to use now. This is sort of a loophole in drug testing where humanitarian issues take precedent due to the severity and negative outcomes of some diseases.

University of Colorado researchers demonstrated that phenylbutyrate stops the progression of Parkinson's disease in mice by turning on a gene called DJ-1 that can protect dopaminergic neurons in the midbrain from dying. Sodium phenylbutyrate is used to treat urea cycle disorders, because its metabolites offer an alternative pathway to the urea cycle to allow excretion of excess nitrogen. It is an orphan drug, it's not clear if sodium phenylebutyrate can be substituted with Butyrate x TUCDA.

SE

[Bolt_Upright]

Yes! I read up on that study. It looked very promising. I even e-mailed the Doctor behind it to find out why they stopped the study: Their grant was not approved.

[SilentEchoes in reply to Bolt_Upright]

Do you think butyrate can be substituted for phenylbutyrate? Phenylbutyrate is prescribed for PD.

[Bolt_Upright in reply to SilentEchoes]

I'm sorry. I don't know. I think it is a shame they stopped the trial. I'm guessing there was no money in the drug. It would not be impossible to obtain the same drugs used in the trial (not a recommendation, just an educated guess).

[OAFC in reply to Bolt_Upright]

It sounds like a promising drug for PD to but like you say there’s probably no money to be made from it or less money made by the big pharmas with all the other meds for PD.So anything like that has no chance of being funded and given to us sufferers of this godforsaken disease IMHO I believe there’s lots of potential cures out there already but to much money to be made with the meds used already 😞😞

[Hidden in reply to SilentEchoes]

I have posted this before so sorry being redundant but to answer your question to the best I am able; I believe that phenylbutyrate was used bc it’s prescription only. TUDCA is OTC.

UDCA , the prescription version of TUDCA (very similar) is being trialed for PD

Sodium Butyrate has been used in various trials.

Therefore, I’m taking sodium butyrate and TUDCA.

Getting our systems to produce their own butyrate is of course the best means of getting it. Prebiotic veges are my preferred means.

[gaga1958]

hidid you decide to try AM0035? if so, what do you think?

[SilentEchoes in reply to gaga1958]

I haven't yet. Adding trehalose first.