Study Shows NMN and Herbal Compounds Prevent Neuron Death in Parkinson’s Models

[Bolt_Upright]

Interesting article: Study Shows NMN and Herbal Compounds Prevent Neuron Death in Parkinson’s Models 2022 nad.com/news/nmn-herbal-med... which explains this paper: SIRT3-mediated deacetylation of SDHA rescues mitochondrial bioenergetics contributing to neuroprotection in rotenone-induced PD models 2022 (which is a preprint. Not peer reviewed) researchsquare.com/article/...

"Key Points: 

NMN prevents neuron death by improving the function of mitochondria in mouse cells modeling Parkinson’s disease (PD). 

Honokiol and icariin, which activate the NAD+ consuming enzyme SIRT3, prevent neuron death and improve the motor performance of a rat model for PD. 

Our cells utilize hundreds of enzymes to operate on a daily basis, yet few are well-renowned for their lifespan-extending and anti-aging effects as sirtuins. Considering that disorders like Parkinson’s and Alzheimer’s disease are a consequence of aging, enhancing the activity of sirtuin enzymes may provide a key to treating these incurable diseases.

In a preprinted (in the process of being peer-reviewed) article published in Molecular Neurobiology, researchers from Zunyi Medical University in China report that sirtuin activators NMN, icariin, and honokiol have a protective effect on models for PD. Shen and colleagues show that nicotinamide mononucleotide (NMN) prevents the death of neurons involved in motor movements (dopamine neurons) by improving mitochondrial function. Furthermore, honokiol and icariin also prevent the death of rat neurons while improving their motor performance, suggesting that these sirtuin activators could treat the symptoms of PD."

"One way to activate sirtuins is by providing them with more fuel, which is precisely the role of NMN. As a precursor to NAD+ (nicotinamide adenine dinucleotide), NMN provides the substrate needed to boost NAD+ levels. Sirtuin enzymes consume NAD+ as fuel, increasing their activity. Sirtuins can also be activated by more direct means, such as through molecules like honokiol (HNK) and icariin (ICA). HNK and ICA enhance the activity of sirtuin3 (SIRT3), a specific type of sirtuin that directly modulates mitochondrial ATP production. "

Bolt's HS understanding: The NMN boosts NAD+ and feed sirtuins and the Honokiol and Icariin enhance the activity of SIRT3.

I don't take NMN, but I do take Niacin, which is a NAD+ booster also. And I already take Magnolia Extract with is a combination of Honokiol and Magnolol. I think I am already in the ballpark of this strategy.

[mauigirl18]

the Bolt's HS Understanding is the best! Thank you!

[Boscoejean]

honokiol is in the magnolia family

en.wikipedia.org/wiki/Honokiol

[Little_apple]

The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure

In a rat PD model induced by ROT, icariin significantly reduced neurotoxicity by activating autophagy in the brain [144].

accumulation of reactive oxygen species and improve the survival rate by introducing more active Nrf2. These results suggest that icariin may serve as an anti-oxidant by the activation of Nrf2 pathway

ncbi.nlm.nih.gov/pmc/articl...

[fabPhilly]

Thanks for your great contributions Bolt. Can you recommend a Honokiol brand? Mine seems to have disappeared!

[Bolt_Upright in reply to fabPhilly]

I'm cheap, so I use this: Swanson Superior Herbs- Magnolia Extract - Standardized

Product Description

Used traditionally to support a healthy stress response and nervous system

Traditional Chinese tonic for cardiovascular health

Standardized to minimum 90% honokiol and magnolol

swansonvitamins.com/p/swans...

It is 30 200 mg capsules. I take 2 at night.

[Lizzy9]

Hello Bolt ~ Are you still taking Magnolia Extract? If so ~ the same brand and how much and any benefits?

Thank you and God bless you and have a fabulous day!

[Bolt_Upright in reply to Lizzy9]

I DO still take Magnolia Extract. 400 mg every night. Same cheap brand. Here is my stack. It has a link to the brand: rbd-pd-protocols.blogspot.c...

I don't know what, if anything, helps. I am better than I was 2 years ago (but remember, I have not been diagnosed with PD), but I do a lot of things.

Ways that I am better: Much less RBD, minor balance issue is gone, random involuntary movements are much decreased, formication is almost gone, orthostatic hypotension is gone. Shoulder and neck pain is less. All these things changes could be the normal course of the disease (I hope not), so I am not saying I have any answers. Check back in 10 years and I will be more confident.

[Lizzy9 in reply to Bolt_Upright]

Thank you Bolt!! I am thinking seriously (need to do a little more reading) of adding it to my HwP’s stack.

Thank you and have a fabulous day!!!

[Lizzy9 in reply to Bolt_Upright]

Hello Bolt ~ I was just reviewing your stack again ~ so you do not take any other supplement for sleep such as melatonin, GABA, for example?

By the way I’m so glad that you’re doing well with improvements. So good to hear!!!

Have a fabulous day and blessings!

[Bolt_Upright in reply to Lizzy9]

No melatonin or gaba for me. I just started taking a break from Methylene Blue. I also started eating sourdough bread a week ago, violating my gluten free rule. That may have been a mistake. I am still playing with that.

Thanks!

[Lizzy9 in reply to Bolt_Upright]

Thank you for getting back to me.

We’ve been eating mostly sourdough bread for quite some time. When we take a break for a month-ish it doesn’t seem to make a noticeable change in my HwP’s system. But down the road…? Who knows..,, We do try to limit it to only one piece. (I’m the bad one.)

Are either you or your wife making it or is it store bought? I make ours.

Blessings~

[Bolt_Upright in reply to Lizzy9]

Store bought. 3 ingredients. Flour, salt, water. Seems good.

[Lizzy9 in reply to Bolt_Upright]

I sure hope you can keep it in your diet!!! I love sourdough!!