Dyskinesia with MP

[Divii]

Hello all! Need some pearls of wisdom. I'm 39 on c/l 25/100 , I take two tablets in one day in divided doses by breaking the tab along with one pramipexole either 0.75 mg ER or 0.375 mg ER. My on time varies every day and the dose too.

I thought it'd be worthwhile to try MP, I have got Now dopa mucuna 800 mg with 15% L- dopamine. Yesterday I took it at night I felt better. But tonight it's a different story. My legs feel like jelly and I Can't even sleep or move. Think I'm overdosed n having dyskinesia.

My questions:

1. Is still worth while to experiment?.

2. Is there any preferred time to take mucuna?

3. Is it recommended that we take a break from c/l and take MP?

4. How long is MP half life and when can I expect the drug to be out of my system?

5- anything I can do to feel better?

Thanks so much 🙏

[park_bear]

1. Given what you are experiencing, my answer would be no

2. No

3. No

4. My guess – it is similar to C/L

5. I do not know what is going on here but this is not dyskinesia. The only answer I have is to give it time to wear off.

[WinnieThePoo in reply to park_bear]

Good answersTo flesh them out a bit, the half life of levadopa is 90 minutes. A drug is usually considered to be out of the system in 5 half lives, so about 8 hours for ldopa. PB is correct in saying that will be the same for c/L and MP. Relatively small doses may be decarboxylated faster than that in the general metabolism

[chartist]

This previous thread on Mucuna Pruriens (MP) may be of help to you and may direct you to specific forum members who are using MP and may be able to offer you a bit more insight on the practical use of MP :

healthunlocked.com/cure-par...

Art

[pearlette]

I defintely think you should not experiment at this stage.

You may have hit some sort of cholinergic imbalance.

Mucuna P has a variabe amount of L dopa substrate the percentage of which differs in each batch. So your 800 mg can contain anywhere between 30 to 80% dopa substrate. Remember it is marketed on a food supplement license not as a pharmceutical drug.

Then the amount absorbed and finally conveyed to the target cells is going to be even more variable in every individual.

There are 4 other major neurotransmitters involved in extrapyramidal motor functions: acetycholine, noradrenalin, histamine and GABA.

The interctions of these in autonomic nervous system functioning are intertwined, complex , not understood and subject to intricate and highly sensitive feedback regulation in the body.

That also means when they have dysregulation we know even less of what is happening. That is almost like playing with radioactive fuel in a nuclear reactor.

A relative cholinergic imbalance can be dangerous !

[RBan]

I found it very difficult to use the powdered Mucuna so I switched to Dopaboost. It’s all measured out for you and easy to swallow and has the added ingredients to make it absorbable. And how I did that was I just gradually switched from Levodopa carbidopa to mucuna. I just did one dose at a time and waited a week in between each change. It does take a while to get used to it and adjust so there needs to be time in between changes. I did check with my neurologist before I tried and he give me the go ahead even though He wasn’t excited about it. I take a half tablet of levodopa carbidopa in the morning and then a full dose of Dopaboost at 11:00 and then a half tablet Of levodopa Carbidopa at 2:30 and.a half dose of Dopaboost at supper. so I switch off. This is because I was having such bad dyskinesia. It helped a lot to do this but I’m still having some dyskinesia from time to time. I’m thinking that I might even have to lower my dosage a bit but then I get other symptoms so there’s a balance and it’s difficult to figure out. but I am much happier with what I’m feeling now being on the natural mucuna with a little bit of levodopa carbidopa. I supplement with magnesium, B3, vitamin D, omega 3, B vitamins etc.

[Sue171]

How long did it take you to complete the entire transition ? And when did you begin? Thank you

[Divii in reply to Sue171]

I tried MP occasionally only; did not fully change from levodopa to MP