Light At The End Of The Tunnel?

[JeanieBeanie]

Posted today on Uk Facebook PD site.

[Bolt_Upright]

Can you tell us any more about the trial please?

[JeanieBeanie in reply to Bolt_Upright]

This is all I know Bolt but Addenbrooks is like Yale or Harvard.

[WinnieThePoo in reply to JeanieBeanie]

addenbrooks will be roger barker. 5 years is probably too short a development time

[Michel0220 in reply to WinnieThePoo]

I had the pleasure of interviewing Roger Barker a few months ago. Please see recording below:

youtu.be/3Rkk6GVIvNg(Not working as expected?)

[Patrickk]

Bydureon (a.k.a., Exenatide), a repurposed Type 2 Diabetes drug is now in third-stage trials in UK for stopping Parkinson’s in its tracks — results expected 2024. Testing — mice, open label, double blind — has been going on since 2010 and it has been positive every time.

scienceofparkinsons.com/201...

According to a very sensitive test, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), 2/3 of Parkinson’s patients are supposed to be insulin resistant. IR may be treated with Bydureon (Exanatide). Just an angle that might get us one step closer to getting Bydureon.

cureparkinsons.org.uk/news/...

South Korean researchers have learned how to dial our cells back to stem cell stage -- and are now administering monkey stem cells to parts of their brains that are short on dopamine producing cells -- with the hope they will fill in and take over the job.

Started this before with stem cells from other monkeys and had some success I think until local immune systems attacked foreign cells.

So there is even realistic hope for a cure.

[jeffmayer]

there have been a lot of false dawns so lets hope its not another dead end imagine being half normal priceless

[eschneid]

It's time we get a break and some good luck!!

[Gcf51]

😀👍🙏 Good News

[Gcf51]

A Google search for Exenatide Parkson in the News reveals:

"PT320 is a sustained-release Exenatide (GLP1 agonist) for biweekly injection (Q2W). Due to its short half-life of 2.4 hours in the plasma of Exenatide, Peptron has developed a long-acting SR-Exenatide (PT320), resulting in sustained elevations of Exenatide for 20 days. With the result of the preclinical and Phase I study of PT320, Peptron is testing the efficacy of PT320 of Parkinson's disease in the ongoing Phase II trial." globenewswire.com/en/news-r...

[Patrickk in reply to Gcf51]

Just curious: I took Exanatide -- first twice a day Byetta; then, once a week Bydureon -- for five years back when I had Type II diabetes. Wondering where the seemingly super short wash out time came from.

[Gcf51 in reply to Patrickk]

Don't know, but what is shown in first link is extended release. scienceofparkinsons.com/201...