5 htp warning

[Todd-pw]

i took a 50 mg 5htp capsule (solgar brand) to try and help me sleep, i had a very bad experience, my cocareladopa did not work for about 8/9 hrs after taking 5 htp it did not help me sleep instead left me feeling paralysed. I would definitely not recommend taking this, might just be me but it was like a living nightmare i have never felt so ill. there are many articles stating the benefits it can have with pd related sleep issues but be very careful this was a horrific experience for me.

[park_bear]

Thanks for bringing this to our attention. There is a known adverse dangerous interaction:

drugs.com/drug-interactions...

carbidopa 5-hydroxytryptophan interaction

"GENERALLY AVOID: Coadministration with carbidopa may potentiate the pharmacologic effects of 5-hydroxytryptophan (5-HTP), which is converted to 5-hydroxytryptamine (5-HT), or serotonin, in vivo. Carbidopa inhibits the peripheral metabolism of 5-HTP, and this effect has been exploited in the treatment of certain neurological disorders ... to enhance the amount of 5-HTP that reaches the central nervous system. However, higher CNS levels of serotonin may also potentiate the risk of serotonin syndrome, which is a rare but potentially fatal condition...

MANAGEMENT: In general, 5-hydroxytryptophan should not be given with carbidopa. If the combination is used, close monitoring is recommended for signs and symptoms of excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia."

[Todd-pw in reply to park_bear]

thanks park bear i will be a lot more vigilant when buying supplements, instead of reading a couple of positive articles then taking sups, lesson well and truly learnt😱

[Smittybear7]

Thanks for sharing. I hope you are doing better. What is 5-HTP?

[Todd-pw]

still feel dodgy but nowhere near as bad as last night, 5 HTP is a supplement that helps aid sleep and calm the nervous system but it felt liked it blocked my cocareladopa for like 10 hrs lots of strong tingling in spine headaches nausea bad anxiety and literally couldn't move for the duration it was in my system like really couldn't move barely swallow. it was the stuff of nightmares. i know when meds are off its difficult to get about ut this was literally like i coudnt feel anypart of my body

[LAJ12345]

Always check interaction with meds when adding a supplement.

[viragkatt]

same here, I had horrible nightmares

[Tibone613]

This is confusing..been researching 5htp as I've been wanting to try it and the research seems positive. ncbi.nlm.nih.gov/pmc/articl... Reduces Levodopa-Induced Dyskinesia via ... ncbi.nlm.nih.gov/pmc/articl...

[CaseyInsights in reply to Tibone613]

There is no confusion.

MANAGEMENT: In general, 5-hydroxytryptophan should not be given with carbidopa.

Beyond that you are free to try it, if you are clear about what you are trying to achieve and mindful that excess could lead to serotonin syndrome 🌺