Nicotinamide Riboside, Vitamin B3 Form Taken in Trial, Aids Cell Energy

[Farooqji]

A modified form of vitamin B3 called nicotinamide riboside (NR), taken as an oral supplement, increased levels of an energy production molecule in the brain and altered brain metabolism over one month in a small group of newly diagnosed Parkinson’s disease patients, according to results of a Phase 1 trial.

parkinsonsnewstoday.com/202...

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healthunlocked.com/cure-par...

[Bolt_Upright]

The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease

pubmed.ncbi.nlm.nih.gov/352...

So a 30 day study using 1,000 mg of nicotinamide riboside a day. Interesting.

"We conducted a double-blinded phase I clinical trial to establish whether nicotinamide adenine dinucleotide (NAD) replenishment therapy, via oral intake of nicotinamide riboside (NR), is safe, augments cerebral NAD levels, and impacts cerebral metabolism in Parkinson's disease (PD). Thirty newly diagnosed, treatment-naive patients received 1,000 mg NR or placebo for 30 days. NR treatment was well tolerated and led to a significant, but variable, increase in cerebral NAD levels-measured by 31phosphorous magnetic resonance spectroscopy-and related metabolites in the cerebrospinal fluid. NR recipients showing increased brain NAD levels exhibited altered cerebral metabolism, measured by 18fluoro-deoxyglucose positron emission tomography, and this was associated with mild clinical improvement. NR augmented the NAD metabolome and induced transcriptional upregulation of processes related to mitochondrial, lysosomal, and proteasomal function in blood cells and/or skeletal muscle. Furthermore, NR decreased the levels of inflammatory cytokines in serum and cerebrospinal fluid. Our findings nominate NR as a potential neuroprotective therapy for PD, warranting further investigation in larger trials. "

[Bolt_Upright in reply to Bolt_Upright]

This had me doubting my Niacin treatment, so I e-mailed one of the doctors involved in the NR trial and asked if Nicotinamide Riboside was better than Nicotinic Acid to boost NAD and lower inflammation, and they told me the two should work about the same to boost NAD and that there is still no conclusive evidence regarding lowering inflammation.

So... I stick with the cheaper straight Niacin.

My only question is... I take 250 mg based on the Auburn trial. The NR trial used 1000 mg to boost NAD. This other trial using Niacin to boost NAD used 750 to 1000 mg: sciencedirect.com/science/a...

I guess I will still stick with my 250 mg time released Niacin.