About Mitopure

[John_morris71]

Please note - just sharing Information. Not an endorsement.

mitopure.com/

timelinenutrition.com/blog/...

timelinenutrition.com/shop/...

[John_morris71]

youtube.com/watch?v=m9-LgoG...(Not working as expected?)

Gets interesting from the 12.00 minute mark

[park_bear]

edit - misunderstanding deleted

[John_morris71 in reply to park_bear]

I am looking for some meaningful benefit - even if it is marginal to begin with, especially if it can help with cognition, given that Mitophagy is happening. Will probably try it for 4 months and then decide whether to continue. Since it is relatively new, not much research has been done on the benefits of prolonged use ( 1 year and beyond). Moreover, we do not know if it can interact and bring about some synergy with other nootropics/supplements.

[park_bear in reply to John_morris71]

edit - misunderstanding deleted

[John_morris71 in reply to park_bear]

In the video above, listening between 30 minute and 33 minutes he mentions the dose very clearly.

Seems there is no ambiguity, or is he misleading ?

[John_morris71]

Thanks - I understand. Chris Rinsch, the guy in the video is the CEO.

But if one dose is equivalent to drinking 6 glasses of PJ then that is something (minus the sugar bomb in the latter).

Also, if one sachet of Mitopure was used during the trial (total of 500mg and not 500mg of UA), then that is some food for thought. That is what he says in the video - during the trial, participants had 500mg, the same as in the sachet. So, I am not sure if 500mg of UA was used in the trial or 500mg of Mitopure was used in the trial (meaning very little of UA as you indicated - in nanograms.)

From the article:

'Subjects were randomized (1:1) to either PJ or A FOOD PRODUCT containing UA (500 mg).

Saw another article - Just FYI.

forbes.com/sites/lisettevoy...

[park_bear in reply to John_morris71]

edit - misunderstanding deleted

[John_morris71 in reply to park_bear]

I can respect your Point of View. The amount of UA is minimal. But I do not think the trial had more UA ( of 500mg) than what is in the sachet. (See link of trial below, where it mentions clearly - 'Fruit flavored food sachet containing fixed dose of Mitopure'.

What I am implying is that the trial did not have 500mg of UA; instead it had whatever UA comes in 1 sachet of Mitopure. As far as assuming that less than 1 microgram has any clinical effect is doubtful, I would hesitate to endorse that view. I know at least one compound that is touted to be effective (at least in research) in very very minute quantities and is now being tested in trials - Anavex compound A 3-71.

With regard to Mitopure :

'Subjects were randomized (1:1) to either PJ or A FOOD PRODUCT containing UA (500 mg).'

The above statement from the article you posted before can be subject to interpretation:

a) The food product was 500mg and contains UA that is not 500mg of UA

b) The food product had 500mg of UA.

The sachet of Mitopure has 500mg contents that relates to a)

This is indicated clearly in the clinical trial below

clinicaltrials.gov/ct2/show...

[park_bear in reply to John_morris71]

edit - misunderstanding deleted

[John_morris71 in reply to park_bear]

I agree that one microgram will probably not have any clinical effect. The point I was making was that there is no scope for confusion that the dosage in the trial was 500mg of UA. It was not 500mg of UA; it was 450 ng as indicated in the sachet.

As far as 3-71 is concerned, I did not put it across the right way. What I meant was 3-71 is more powerful than 2-73 (both Anavex compounds) by big factor - if I am not mistaken by a factor of close to 1000 if not more. I need to do some digging/research and find out, before posting. I am no expert in pharmacology or pharmacokinetics and admit that my knowledge is just 'internet knowledge'

[park_bear in reply to John_morris71]

A search on most potent medication yielded fentanyl – minimum intranasal dose 50 micrograms

[John_morris71 in reply to park_bear]

FYI - Found this as a part of the series. Listen to what he says in the beginning regarding amount of UA in the sachet of 0.1 oz (3gms) . 500mg of UA ?

youtube.com/watch?v=5fct5UE...(Not working as expected?)

[Hidden in reply to John_morris71]

I think asking the ceo directly would be very worth while. He is not going to concede. It will either be a clarification or silence. But, I don’t want to accept silence. I’m tired of the BS of this industry. I think we should type up a well written inquiry and gather as many names as possible and submit our question to the company. Who are the investors?

[John_morris71 in reply to Hidden]

clinicaltrials.gov/ct2/show...

See under 'Arms and Interventions'

[Hidden in reply to John_morris71]

I’m not seeing results? The intentions are outlined but am I missing the results? Someone high up at Nestle is involved.

What is your opinion?

[John_morris71 in reply to Hidden]

You will find results in some research paper or journal. Not sure about someone high up at Nestle being involved. Anything can happen when there is money to be made.

[Hidden in reply to John_morris71]

He is listed on the website of the company

[John_morris71 in reply to Hidden]

Some more info (opinion) - FWIW

ihmc.us/stemtalk/episode-118/

Listen from 30.27 to 33.00 minute mark

[Hidden in reply to John_morris71]

This podcast episode is excellent. I really like this podcast in general but this episode is so informative. Thank you! Based on what she is saying about ALZ and the amyloid beta being the wrong target, I suspect the same might apply to PD and alpha synuclein. Although when the vagus nerve has been cut and therefore alpha synuclein can not travel from the gut to the brain, the risk of PD is reduced. It only being reduced and not abated though sounds like alpha synuclein is a contributor but not the sole culprit. But, all that said, increasing autophagy sounds like it is certainly a good idea and any means of increasing autophagy should be pursued.

Spermidine is of great interest to me and Apigenin.

[kevowpd in reply to Hidden]

I would read this. No answers, but interesting.

mdpi.com/2218-273X/12/2/228...

[Hidden in reply to kevowpd]

Interesting. Unfortunately it validates what I have been thinking. Targeting AS is overly simplistic and will fail. So, Ambroxol, Montelukast , and Exenatide are going after the wrong target?

Dr. Bredesens book has a terribly arrogant title which he has said was chosen by his publisher. I hate the misleading title. But, to his credit he is changing the focus in ALZ by repeatedly admonishing the pharma industry for so relentlessly chasing after amyloid beta plaques. I figure his protocol is basically saying, “seeing as there is nothing else to offer you, at least try these interventions that you can implement yourself”.

our genetics has changed very little in the last couple of centuries but look at the rise in neurological and autoimmune diseases. If our genetics has not changed, what has?

Is Ambroxol a waste? Is Exenatide a waste? And Montelukast too?

[John_morris71 in reply to Hidden]

Amyloid beta is what BP has been chasing and still chasing, even after decades of repeated failures - thanks to the FDA that overruled the advisory committee which had overwhelmingly rejected Biogen's drug and approved it; only for the medical community to reject the drug - so much so that Biogen cut its price by half from 56k to 28; yet there are no takers. A couple of big guys in Biogen left the company.

I like Anavex's approach - they are trying out a drug that deals with sigma1 Receptors and acts upstream trying to restore homeostasis. Currently extended phase 2 is on going in Australia (more than 500 participants - most of them opted to continue taking the drug past the trial duration). Should have the results before End of Year.

[Hidden in reply to John_morris71]

Agreed. Do you have an opinion of Ambroxol and Exenatide? Both are being trialed for both PD and ALZ. Some of us are using them, myself included. I’m concerned both are being pursued due to the somewhat outdated belief that the protein aggregates are the culprit. Regarding Anavex, agreed.

We must look for root causes instead of bailing water out of a sinking boat.

[John_morris71 in reply to Hidden]

Sorry - No idea about Ambroxol and Exenatide. My mother is still taking Levodopa and no other PD drug. (I am giving her many supplements, including Spermedine - just started). Still thinking about Mitopure.

[John_morris71 in reply to Hidden]

FYI -

I emailed them and got this response.

...........................................................................................................................................................................

Hello,

Thank you for reaching out to us with your question. Each daily dose (1 packet) will contain 500mg of Mitopure. I hope this information helps and please let me know if you need anything else.

In health,

Darren

Customer Support

..................................................................................................................................................................................

Hello Darren

Thanks for the response.

So you are saying that each sachet of timeline contains 500mg of Urolithin A.

Is Mitopure the proprietory name for purified form of Urolithin A ?

..................................................................................................................................................................................

Hi ,

That is all correct. Each packet or "sachet" contains 500mg of Mitopure. Mitopure is our trademarked name for the highly pure form of Urolithin A that we manufacture.

In health,

Darren

Customer Support

[Bolt_Upright in reply to John_morris71]

Great work John! I did a search to try and prove them wrong, and found they are using mitopure in a clinical trial: Effects of Mitopure (Urolithin A) on Skeletal Muscle Function, Iron Metabolism and Endurance Performance (ENDURO)

clinicaltrials.gov/ct2/show...

That is pretty convincing.

It is not cheap. You will spend $25 a week. They have it at Amazon: amazon.com/Celltrient-Stren...

I think it costs even more at the mitopure site.

[John_morris71 in reply to Bolt_Upright]

The one on Amazon is not Mitopure from Amazentis. It is another company (Nestle)? Mitopure is available only on their website.

[Bolt_Upright in reply to John_morris71]

You may be correct. The Celltrient brand at Amazon says in has Urolithin A (as Mitopure TM), but they also have very mixed reviews.

Celltrient

[John_morris71 in reply to Bolt_Upright]

LOL - I read one of the comments form a guy called Brad Jensen who writes :

'Aging is a genetic disease. There is no real reason for your body to age. This helps reduce the effects of aging by helping your mitochondria. Well recommended. I take every day. '

[Bolt_Upright in reply to John_morris71]

Interesting, in the trial they are using 250 mg a day. So maybe you could make this last by only taking 250 mg a day.

I think I will have some pomegranate juice: Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain 2019 ncbi.nlm.nih.gov/pmc/articl...

[John_morris71 in reply to Bolt_Upright]

In the trial, it is 4 soft gels/day, each 250 mg if I am not mistaken. So it will be 1000mg - like taking 2 sachets/day. The website also has the info that each soft gel has 250mg (serving size 2 gels for total of 500mg).

You will have to consume 6 glasses of Pom. Juice to get the same effect as 1 sachet of Mitopure. At least that they say. Add to it the sugar intake involved.

[Bolt_Upright in reply to John_morris71]

Good catch, I read that wrong. So the trial is using 1000 mg a day. That is really costly.

[John_morris71 in reply to Bolt_Upright]

Agree. It is costly. May be could do it for 2 months @ 1000mg of Mitopure and then take a break for about 2 to 3 months to see if it really helps (instead of doing 500mg for 4 months and then taking a break for another 2 months or 4 months). Then depending on whether it is worth it, may be one could continue taking 500mg daily for a few months ?

Not easy - as you said it is costly. But if it can give both physical and cognitive benefit, may be it is worth a try.

[Bolt_Upright in reply to John_morris71]

Yes, that is a lot of sugar. And 6 glasses a day will cost more than mitopure.

[Hidden in reply to Bolt_Upright]

Bolt, the podcast posted above is top notch. I love Stem Talk. The doctor from the Buck who has nothing to gain from this that I can tell speaks highly of it. She does elaborate that senolytics should not be used indefinitely bc they can kill cells

[faridaro in reply to John_morris71]

I find it suspicious that Darren didn't state that each packet or "sachet" contains 500mg of Urolithin A. The fact that Mitopure according to him is the "trademarked name for the highly pure form of Urolithin A" still doesn't convince me that Mitopure is 100% Urolithin A, especially that there is no amount of UA listed on their sachets:

timelinenutrition.com/shop/...

[John_morris71 in reply to faridaro]

No problem

[Hidden]

Listening to Dr. Mark Hyman he mentioned that he uses it in his smoothies. He was not stating it in the context of endorsing it. Interesting that he uses it though. I see no down side other than potentially wasting funds.