I am a Parkinson's patient with Type II diabetes. My Metformin treatment and Trulicity treatment for diabetes is believed to cause problems with my Parkinson's.
It's a "catch 22". I also have neuropathy in my legs and feet caused by my diabetes. I cannot afford to stop treating either the Parkinson's or Diabetes.
Has anyone experienced this situation and what did you do?
I don't have either one, but do a little reading on Berberine and melatonin as they are good for both PD and T2DM. Here are a few studies to help get you started on Berberine.
ncbi.nlm.nih.gov/labs/pmc/a...
ncbi.nlm.nih.gov/labs/pmc/a...
ncbi.nlm.nih.gov/labs/pmc/a...
And PD :
ncbi.nlm.nih.gov/labs/pmc/a...
ncbi.nlm.nih.gov/labs/pmc/a...
pubmed.ncbi.nlm.nih.gov/344...
And then melatonin :
ncbi.nlm.nih.gov/labs/pmc/a...
ncbi.nlm.nih.gov/labs/pmc/a...
pubmed.ncbi.nlm.nih.gov/256...
sciencedirect.com/science/a...
ncbi.nlm.nih.gov/labs/pmc/a...
And a third option if you are so inclined as it is quite useful for both health conditions also.
frontiersin.org/articles/10...
And lastly , NIR exposure from the sun which will also be useful for both conditions.
This should be enough info to get you started in your research into these ideas which have significantly more health benefits than just these two diseases because of their multiple methods of action and overall health promoting effects.
Good luck!
Art
I'm not diabetic but exenatide would be on my short list of possible drugs to raise with my treating doctor given that it's currently in phase 3 for slowing PD.
Exanatide is a great idea as it might amount to a free punt if you can get a prescription from one of your medical team. You might want to test your B12 levels - endocrinology.org/press/pre....
Also re PD B12 might be beneficial: parkinsonsnewstoday.com/201...
Your medical team can advise but have a good dig around yourself pre consultation as you’ll want to be all over the subject matter.
I agree with the comments about exenatide. If I had diabetes and PD, that is prescription I would ask for. And, I would read every link provided by chartist. He is a walking encyclopedia.
Why do you think Metformin is not good for you? I accept it may cause B12 deficiency (which can be another cause of peripheral neuropathy) and interfere with Magnesium absorption but, if you supplement with those, is there any other downside with respect to your Parkinson's Disease? My husband who has PD takes Metformin for his pre-diabetes and I thought it might help the PD given it is touted as an anti-aging drug. A quick look online shows review articles hypothesising that Metformin should be trialled as a treatment to slow progression of PD.
Trulicity, is the same type of drug being tested for stopping Parkinson's progression (3rd stage finished 2024, UK) -- but Trulicity does not cross the blood brain barrier.
biospace.com/article/recent...
I was on Bydureon (Exanatide) for 5 years before my Type II went into remission. Did not need Metformin myself. I can't imagine why you neuro does not have you on Bydureon instead of Trulicity. I wish I could get my Type II back just so I could get back on Bydureon.
[cut-and-paste]
Bydureon (a.k.a., Exenatide), a repurposed Type 2 Diabetes drug is now in third-stage trials in UK for stopping Parkinson’s in its tracks — results expected 2023. Testing — mice, open label, double blind — has been going on since 2010 and it has been positive every time.
scienceofparkinsons.com/201...
According to a very sensitive test, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), 2/3 of Parkinson’s patients are supposed to be insulin resistant. IR may be treated with Bydureon (Exanatide). Just an angle that might get us one step closer to getting Bydureon.
cureparkinsons.org.uk/news/...
[snip}
I am type 2 diabetic and have PD taking metformin and madopar. I intend to write to my GP requesting exanatide as its in the stage 3 trials. Tried to join the trials and they refused because i have Diabetes ?? Excuse me while i bash my head against a brick wall LOL
🤣🤣🤣i hear your pain...
My husband also had problems with Metformin. He tried it 2 or 3 times and had the same problem. He now takes Trajenta (linagliptin) 5mg per day and has had no problem with that.
Ciao, potrei sapere che tipo di problemi? Mo marito prende gli stessi farmaci.
It affected his PD.
Have you also considered a keto diet? Obviously, with your doctors support, it might control the type 2 and also help the PD.
I want to thank everyone for the responses you are providing. They all serve to point out how diverse the opinion is on the subject. I find the medical community available to me with much less seeming knowledge of the subject and still riding the same horse they rode in on years ago. I believe I will go to Phoenix and try Mayo to see if they can help and build upon your suggestions.
SYMBYX device for Parkinson's treatment
New parkinson's treatment available on the NHS 
If you had 10 million dollars to spend on your Parkinson's treatment...
What symptoms do you get if you take Parkinson's medication late or miss a dose.
We can change the course of Parkinson's treatments. 
