Repurposing of drugs for the treatment of Parkinson's Disease.

[Ianfrizell]

Hi all

This is a link to my latest vlog, about the repurposing of drugs for the treatment of Parkinson's Disease.

youtube.com/watch?v=iyxP3g4...(Not working as expected?)

Cheers,

Ian

[FMundo]

Ian you certainly haven't overstated the problem or the frustration the PD community has with Clinical Testing. For either of the drugs you mentioned there is a 8-10 year wait before we'll see drugs FDA approved. Most of us will be pushing up daisies by then. Consequently the smart ones aren't waiting.

[cshamb in reply to FMundo]

No waiting does that mean you are getting the drug and taking it yourself?

[FMundo in reply to cshamb]

Yes. If it's a prescription drug obviously that means getting an M.D. to prescribe the drug which she can do. Its called prescribing "off label".

[Isthistheone in reply to FMundo]

Frank, right you are before the latest trials are completed for the repurposing of nilotinib, brand name Tasigna for Parkinson's Disease. Tasigna is FDA approved for a specific type of leukemia. Any licensed physician can prescribe it, off label, for any condition the doctor feels will benefit the patient. Today is 101 days for me being on Tasigna. I posted my results on another thread just this morning Repurposing of nilotinib for Parkinson's. I firmly believe my improving health is the result of Tasigna. Expensive yes, $13,800 for three months. Very fortunate insurance picked up the costs. Started June 1, one 200 mg capsule once per day. In my opinion this is the one!

Take care and keep moving,

[Farooqji in reply to Isthistheone]

Who prescribed you Tasigna ? Just checked and as per following website, Phase 2 study is expected to end in July 2020 and then will Phase 3 be initiated.

parkinsonsnewstoday.com/nil...

How does it improves health i.e. does it improve motor symptoms mainly tremor?

Please keep us updated

[aspergerian]

See also, nortriptyline.

sciencedaily.com/releases/2...

[Bazillion]

Hi Ian totally agree we need a cure NOW!

I think repurposing drugs is a good idea as it reduces the research approval time, but I think they need to be looking at choosing the right drugs that treat PD motor and non motor symptoms that may also slow down the disease.

The most recent one being Nortryptiline.

If you are a PWP and are depressed, have neuropathic pain and sleep problems surely it's a no brainier not to try it if the recent research shows it slows down the clumping of alpha synneuclein.

I would rather give that a try than take antidepressants,analgesics and sleeping tablets that haven't been shown to help slow down progression of PD!