Autophagy Mastery - book recommendation - Cure Parkinson's

Cure Parkinson's

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Autophagy Mastery - book recommendation

bassofspades profile image

Autophagy Mastery by Elouisa Smith

amazon.com/dp/1800600747/re...

Mentions that it can prevent Parkinson's disease and explains how. The kindle version is $2.99, I got the audio book from my local library.

Autophagy is the process that your body undergoes at the cellular and molecular level to clear up the "garbage" and from this, recycle the building blocks into materials that your cells can use for nourishment and repair. In reference to Parkinson's, this means amplifying the ability of cells to eliminate the misfolded proteins that accumulate and destroy our fragile dopaminergic neurons, a process that can be inherently weakened by genes found at the root of Parkinson's. The book does specifically mention this and goes into detail very thoroughly. It's actually a good read, though. Not written in overly technical jargon for the most part , yet it is complete beyond the basics.

The book describes the process and lays out the plan we can follow to most effectively harness this power. It could potentially prevent, halt and perhaps with luck, reverse Parkinson's as well as obesity and many other degenerative conditions, including diabetes, Alzheimer's, inflammatory diseases, skin conditions, and aging. Diet, exercise and sleep are key, and it explains why and how to optimize all three.

In my case, severe sleep deprivation probably led me to a young onset version of Parkinson's disease. After reading this book I can more clearly understand this. After utilizing the methods outlined in this book, I have already noticed improvement in several symptoms, and I'm just getting started. For example , my morning tremors were the worst of the day but now they're gone. Walking gave me severe pain in the gluteal, SI joint, lower back and hamstring areas, these pains are greatly reduced now. I haven't had any orthostatic hypertensive episodes either, which is something that I had been experiencing the last few months. My blood pressure seems to be more stable. I started the plan just this week, too.

At $2.99 for the kindle version and free if your library has it, you can't pass this one up. I anxiously await all your reports of success!

Happy New Year my good friends !

Bassofspades

28 Replies

Very exciting bassofspades. Thanks for sharing.

I just now sent you a message! READ THIS BOOK!😊

Thank you so much for this.

But what if PD actually was an excesss of autophagy ? Much like an auto-immune disorder ?

It's my concern : could'nt we then accelerate against our will the disease process, instead of healing ?

bassofspades profile image
bassofspades in reply to Xenos

What makes you think that it could be an excess of autophagy?

Thanks for the book recommendation. Autophagy is part of my treatment plan, mostly through intermittent fasting. But I've read that it can be a double-edged sword for PD.

FROM MY DIGITAL FOLDER, here are the concluding notes of a very extensive but technical 2012 PubMed paper found at

ncbi.nlm.nih.gov/pmc/articl...

BASIC SCIENCE RESEARCH AND CLINICAL TREATMENT

Based on the significant roles of mitochondria and autophagy in PD, maintaining and stabilizing mitochondrial function or promoting the degradation of damaged mitochondria might benefit the protection of dopaminergic neurons.

Data on the possible connection between defects in mitophagy and PD suggest that modulation of autophagy might be one avenue for treating some types of this disease.

However, autophagy is described as a double-edged sword, because both reduced and excessive autophagy can be detrimental; therefore, simply upregulating autophagy is not a practical course of action, and the application of autophagy-inducing drugs must be undertaken with extreme caution. [My note: Not sure if there's a concern when simply fasting vs. using drugs to induce autophagy.]

CONCLUDING REMARKS

The turnover of proteins has been the focus of attention across neurodegenerative diseases, given that many, if not all, of these diseases show characteristic protein aggregation as part of their cellular pathology.

There have been tremendous advances in our understanding of the causes of PD. Novel genes causing familial PD have been discovered, and have been shown to be involved in the autophagy pathway, one of the major proteolytic systems that maintain cellular protein homeostasis.

Because autophagy is part of the cell’s homeostatic machinery, maintaining a proper level of autophagy is important for minimizing abnormal protein aggregates and for facilitating organelle turnover.

Discovery of therapeutic agents that boost autophagic activity or that directly maintain mitochondrial homeostasis, could potentially reduce neuronal loss and slow down disease progression.

A better understanding of the regulatory mechanism of autophagy in the pathogenesis of PD will enable the identification of possible methods for clinical intervention.

>>> ' Discovery of therapeutic agents that boost autophagic activity or that directly maintain mitochondrial homeostasis, could potentially reduce neuronal loss and slow down disease progression. ' <<<

This is what melatonin does, up regulates or down regulates Autophagy when needed and maintains the integrity of the mitochondria.

ncbi.nlm.nih.gov/labs/pmc/a...

ncbi.nlm.nih.gov/labs/pmc/a...

Art

Thanks for the tip! Added to my kindle holiday reading!

I paid the $2.99 and read on my kindle. Actually skimmed it by reading the first sentence of every paragraph. Something I learned during 8 years of college; Reading just the first sentence lets you get the 'gist' without wasting time. So it's about autophagy, the act of breaking down old tissue to be recycled and remodeled into new tissues. The book says that studies say that fasting stimulates autophagy, as does exercise and cold temperatures. Not in the book but I believe autohemotherapy does the same. This is extracting blood from a vein and quickly reinjecting the blood into a muscle. The body treats that blood as a foreign body and mobilizes healing cells to turn it into healthy, young tissues.

bass,

Autophagy is a relatively new interest of mine and I just received a book on the subject called the, " Angel And The Assassin ". I haven't read it yet, but it was recommended to me by my natural Doctor.

On a related note, melatonin has the ability to up regulate or down regulate autophagy as needed by the body :

ncbi.nlm.nih.gov/labs/pmc/a...

Art

Thanks Art. Personally, I can't take melatonin. Even a miniscule dose gives me nightmares.

bass,

That's the beauty of my latest melatonin post, you don't have to supplement melatonin or suffer any side effects, but get the benefits through two different ways!

Art

I just keep the room dark and don't play with my phone while I'm in bed!

"Angel And The Assassin" sounds like a Glenn Ford movie from the 50s.

You're thinking of Angel and the bad man with John Wayne.

I think you are going to ace your test.

I put in a request for it with my library. Looks awesome!

"Angel And The Assassin" by Donna Jackson Nakazawa is 320 pages with 246 reviews and an average 5 stars at Amazon.

Donna Jackson Nakazawa is the author of three previous books exploring the intersection of neuroscience, immunology, and emotion: Childhood Disrupted, which was a finalist for the 2016 Books for a Better Life award, The Last Best Cure, and The Autoimmune Epidemic. For her written contributions to the field of immunity, she has received the AESKU award and the National Health Information Award, which recognizes the nation’s best magazine articles on health. Jackson Nakazawa’s work has appeared in Wired, Stat, The Boston Globe, The Washington Post, Health Affairs, Aeon, Parenting, AARP Magazine, and Glamour, and has been featured on the cover of Parade as well as in Time. She has appeared on Today, NPR, NBC News, and ABC News, and has been the recipient of writing-in-residence fellowships from the Virginia Center for the Creative Arts, Yaddo, and the MacDowell Colony. She lives with her family in Maryland.

She has blog posts on her Amazon page: amazon.com/Donna-Jackson-Na...

Your Healing Narrative: Write-to-Heal With Neural Re-Narrating donnajacksonnakazawa.com/yo...

Quiet Your Body and Mind donnajacksonnakazawa.com/qu...

Good stuff (maybe)

bass,

I just started reading Angel And The Assassin and I think I may have misunderstood what my doctor said about this book as it appears to be about Microglia, not Autophagy, so you may want to skip it, but they seem to have similar activities, while melatonin seems to have a buffering effect with both.

Art

Thanks so much for the mention - The Angel and the Assassin. The free sample was so fascinating - I made a purchase.

Excellent writer and I do expect to learn a good bit about microglia.

So you are forgiven for taking the thread off-course 🤗

P.S: Might be good info her for PwP, as it points to a mind-body connection mediated by the microglia.

I just started reading it and it sounds like it is going to be interesting!

Art

Great! I'll be keeping an eye out for your"book report"!

You may find this interesting, bass :

ncbi.nlm.nih.gov/labs/pmc/a...

Art

yes, I skimmed most of it and especially read the part pertaining to Parkinsons, and it seems to be in agreement with what I mentioned above. So, hoping to see good things with Autophagy Mastery! BTW, I went to my regular neurologist checkup today, and, not surprising, he never heard of this. I had to, once again, educate my doctor on the subject. Should I send him a bill? He never heard of Exenatide either.

Yes, definitely on the bill, maybe he'll get the hint!

Art

Xenos profile image
Xenos in reply to chartist

Overall, we update the current knowledge of autophagy and microglia, and highlight as yet unexplored mechanisms whereby autophagy in microglia may contribute to CNS disease and senescence.

A double-edge sword indeed (?)

chartist profile image
chartist in reply to Xenos

I think that is the point, sometimes autophagy needs to be modulated up or down. Interestingly, melatonin has shown the ability to do both :

In this study melatonin activates autophagy to good effect :

ncbi.nlm.nih.gov/labs/pmc/a...

In this study, melatonin inhibits autophagy to good effect :

ncbi.nlm.nih.gov/labs/pmc/a...

Melatonin is just one way to modulate autophagy. Melatonin is a smart molecule.

More specifically to PD and other neurodegenerative diseases :

ncbi.nlm.nih.gov/labs/pmc/a...

A quote from the above study :

>>> ' Melatonin can prevent autophagy and protect neurodegeneration. Melatonin promotes basal levels of autophagy under physiological conditions, thereby maintaining the homeostasis and survival of neurons. The effect of melatonin on autophagy might be related to the level of activation of catabolic processes and specific cellular conditions [190]. ' <<<

Art

I have some books to read, thanks!

Thank you for sharing the book and your experience with us, Bass.

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