Mentions that it can prevent Parkinson's disease and explains how. The kindle version is $2.99, I got the audio book from my local library.
Autophagy is the process that your body undergoes at the cellular and molecular level to clear up the "garbage" and from this, recycle the building blocks into materials that your cells can use for nourishment and repair. In reference to Parkinson's, this means amplifying the ability of cells to eliminate the misfolded proteins that accumulate and destroy our fragile dopaminergic neurons, a process that can be inherently weakened by genes found at the root of Parkinson's. The book does specifically mention this and goes into detail very thoroughly. It's actually a good read, though. Not written in overly technical jargon for the most part , yet it is complete beyond the basics.
The book describes the process and lays out the plan we can follow to most effectively harness this power. It could potentially prevent, halt and perhaps with luck, reverse Parkinson's as well as obesity and many other degenerative conditions, including diabetes, Alzheimer's, inflammatory diseases, skin conditions, and aging. Diet, exercise and sleep are key, and it explains why and how to optimize all three.
In my case, severe sleep deprivation probably led me to a young onset version of Parkinson's disease. After reading this book I can more clearly understand this. After utilizing the methods outlined in this book, I have already noticed improvement in several symptoms, and I'm just getting started. For example , my morning tremors were the worst of the day but now they're gone. Walking gave me severe pain in the gluteal, SI joint, lower back and hamstring areas, these pains are greatly reduced now. I haven't had any orthostatic hypertensive episodes either, which is something that I had been experiencing the last few months. My blood pressure seems to be more stable. I started the plan just this week, too.
At $2.99 for the kindle version and free if your library has it, you can't pass this one up. I anxiously await all your reports of success!
Happy New Year my good friends !
Bassofspades
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Thanks for the book recommendation. Autophagy is part of my treatment plan, mostly through intermittent fasting. But I've read that it can be a double-edged sword for PD.
FROM MY DIGITAL FOLDER, here are the concluding notes of a very extensive but technical 2012 PubMed paper found at
Based on the significant roles of mitochondria and autophagy in PD, maintaining and stabilizing mitochondrial function or promoting the degradation of damaged mitochondria might benefit the protection of dopaminergic neurons.
Data on the possible connection between defects in mitophagy and PD suggest that modulation of autophagy might be one avenue for treating some types of this disease.
However, autophagy is described as a double-edged sword, because both reduced and excessive autophagy can be detrimental; therefore, simply upregulating autophagy is not a practical course of action, and the application of autophagy-inducing drugs must be undertaken with extreme caution. [My note: Not sure if there's a concern when simply fasting vs. using drugs to induce autophagy.]
CONCLUDING REMARKS
The turnover of proteins has been the focus of attention across neurodegenerative diseases, given that many, if not all, of these diseases show characteristic protein aggregation as part of their cellular pathology.
There have been tremendous advances in our understanding of the causes of PD. Novel genes causing familial PD have been discovered, and have been shown to be involved in the autophagy pathway, one of the major proteolytic systems that maintain cellular protein homeostasis.
Because autophagy is part of the cell’s homeostatic machinery, maintaining a proper level of autophagy is important for minimizing abnormal protein aggregates and for facilitating organelle turnover.
Discovery of therapeutic agents that boost autophagic activity or that directly maintain mitochondrial homeostasis, could potentially reduce neuronal loss and slow down disease progression.
A better understanding of the regulatory mechanism of autophagy in the pathogenesis of PD will enable the identification of possible methods for clinical intervention.
>>> ' Discovery of therapeutic agents that boost autophagic activity or that directly maintain mitochondrial homeostasis, could potentially reduce neuronal loss and slow down disease progression. ' <<<
This is what melatonin does, up regulates or down regulates Autophagy when needed and maintains the integrity of the mitochondria.
I paid the $2.99 and read on my kindle. Actually skimmed it by reading the first sentence of every paragraph. Something I learned during 8 years of college; Reading just the first sentence lets you get the 'gist' without wasting time. So it's about autophagy, the act of breaking down old tissue to be recycled and remodeled into new tissues. The book says that studies say that fasting stimulates autophagy, as does exercise and cold temperatures. Not in the book but I believe autohemotherapy does the same. This is extracting blood from a vein and quickly reinjecting the blood into a muscle. The body treats that blood as a foreign body and mobilizes healing cells to turn it into healthy, young tissues.
Autophagy is a relatively new interest of mine and I just received a book on the subject called the, " Angel And The Assassin ". I haven't read it yet, but it was recommended to me by my natural Doctor.
On a related note, melatonin has the ability to up regulate or down regulate autophagy as needed by the body :
That's the beauty of my latest melatonin post, you don't have to supplement melatonin or suffer any side effects, but get the benefits through two different ways!
"Angel And The Assassin" by Donna Jackson Nakazawa is 320 pages with 246 reviews and an average 5 stars at Amazon.
Donna Jackson Nakazawa is the author of three previous books exploring the intersection of neuroscience, immunology, and emotion: Childhood Disrupted, which was a finalist for the 2016 Books for a Better Life award, The Last Best Cure, and The Autoimmune Epidemic. For her written contributions to the field of immunity, she has received the AESKU award and the National Health Information Award, which recognizes the nation’s best magazine articles on health. Jackson Nakazawa’s work has appeared in Wired, Stat, The Boston Globe, The Washington Post, Health Affairs, Aeon, Parenting, AARP Magazine, and Glamour, and has been featured on the cover of Parade as well as in Time. She has appeared on Today, NPR, NBC News, and ABC News, and has been the recipient of writing-in-residence fellowships from the Virginia Center for the Creative Arts, Yaddo, and the MacDowell Colony. She lives with her family in Maryland.
I just started reading Angel And The Assassin and I think I may have misunderstood what my doctor said about this book as it appears to be about Microglia, not Autophagy, so you may want to skip it, but they seem to have similar activities, while melatonin seems to have a buffering effect with both.
yes, I skimmed most of it and especially read the part pertaining to Parkinsons, and it seems to be in agreement with what I mentioned above. So, hoping to see good things with Autophagy Mastery! BTW, I went to my regular neurologist checkup today, and, not surprising, he never heard of this. I had to, once again, educate my doctor on the subject. Should I send him a bill? He never heard of Exenatide either.
Overall, we update the current knowledge of autophagy and microglia, and highlight as yet unexplored mechanisms whereby autophagy in microglia may contribute to CNS disease and senescence.
>>> ' Melatonin can prevent autophagy and protect neurodegeneration. Melatonin promotes basal levels of autophagy under physiological conditions, thereby maintaining the homeostasis and survival of neurons. The effect of melatonin on autophagy might be related to the level of activation of catabolic processes and specific cellular conditions [190]. ' <<<
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A Valuable Reference Book for Parkinson's
Fasting for autophagy and decreasing plaques and misfolded proteins 
Interview of Daphne Bryan following the publication of her book: “Parkinson’s and the B1 therapy”.
